Treatment Of Locally Recurrent Rectal Cancer

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Locally Advanced Rectal Cancer - ki

Treatment of patients with locally advanced primary rectal cancer and recurrent rectal cancer remains a challenge but, with radical surgical resection 5-year survival rates up to 50 60% is reached at dedicated centres. The aim of this thesis was to analyse management, outcome and the quality of life in patients with

Locally recurrent rectal cancer: treatment options

Locally recurrent rectal cancer: treatment options Vaneja Velenik Department of Radiotherapy, Institute of Oncology Ljubljana, Slovenia Background. Although the preoperative radiochemotherapy and the optimised surgical technique have im-proved the outcome in patients with rectal cancer, the local recurrence still remains a therapeutic problem.

Pelvic exenteration and composite sacral resection in the

The incidence of rectal cancer recurrence after surgery is 5 45%. Extended pelvic resection which entails En-bloc resection of the tumor and adjacent involved organs provides the only true possible curative option for patients with locally recurrent rectal cancer. Aim: To evaluate the surgical and oncological outcome of such treatment.

Recurrent Rectal Cancer

Locally Recurrent Rectal Cancer Vermaas et al [3] compared the results of preoperative RT and surgery to surgery alone in patients with recurrent rectal cancer. Local control after preoperative treatment was statistically significantly higher at 3 and 5 years compared to the surgery-alone group.

Impact of the preoperative prognostic - BMC Cancer

of locally recurrent rectal cancer Masakatsu Paku, Mamoru Uemura*, Masatoshi Kitakaze, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki and Hidetoshi Eguchi Abstract Background: Local recurrence is common after curative resections for rectal cancer. Surgical intervention

RESEARCH Open Access The efficacy and dosimetry analysis of CT-

Locally recurrent rectal cancer (LRRC) is defined as an intrapelvic recurrence following a primary rectal cancer resection, with or without distal metastasis. Concurrent preoperative chemoradiotherapy followed by total mesorectal excision (TME) surgery plus systemic chemotherapy is the first recommended standard treat-

Laparoscopic Salvage Surgery for Locally Recurrent Rectal Cancer

Conclusion Laparoscopic surgery for locally recurrent rectal cancer has short-term benefits over open surgery and has potential as a treatment option for locally recurrent rectal cancer. Keywords Laparoscopicsurgery Locallyrecurrentrectal cancer Anastomoticsite Lateralpelviclymphnode Introduction Recent advances in neoadjuvant

Recurrent Rectal Cancer

chemotherapy for unresectable recurrent rectal cancer is a feasible and effective therapeutic approach, and can reduce distant metastasis rate and improve the survival rate. 1 9. You YT, Chen JS, Wang JY, et al. Concurrent chemoradiotherapy in the treatment of locally recurrent rectal cancer. Hepatogastroenterology. 2013;60(121):94-98

University of Groningen IORT-containing multimodality

In conclusion: treatment of primary locally advanced and locally recurrent rectal cancer is frustrated by the fact that a radical resection can often not be achieved, and that the EBRT dose is limited by the normal tissue tolerance. An intraoperatively delivered boost of irradiation can overcome this aforementioned problem.

Gastrointestinal Clinical Trials - cancer.uci.edu

Rectal Cancer Survivors Telephone Diet Modification Coaching (AIMS-RC) vs Telephone Health Education Prior history of rectosigmoid colon or rectal cancer with post-surgical permanent ostomy or anastomosis Last date of treatment for rectal cancer (surgery, chemo, RT) must be at least 6 months but no more than 24 months prior to registration

Management of recurrent rectal cancer: A population based

recurrent rectal cancer[4,6,13-16]. However, these reports present mainly results from randomised clinical trials or specialised institutes, which are known to be biased[17]. There are only a few population-based reports on the treatment of locally recurrent rectal cancer disease[13,18], although they are probably the best reflection of daily

A watch-and-wait approach for locally advanced rectal cancer

management of locally advanced rectal cancer with the goal of decreasing rates of local recurrence. Response to neoadjuvant chemoradiation is a predictor of survival.6,7 After treatment, roughly 15% of patients have a pathological complete response on assessment of the surgical specimen (no detectable tumour cells).7,8

by Stein Gunnar Larsen

and treatment of the about 500 patients with locally advanced and recurrent rectal cancer in the studies in the thesis, and to the nurse staff at the out-patient clinic for support in the systematic follow-up.

1214 Review Article (Current Status of Colorectal Cancer

The management of patients with locally advanced or recurrent rectal cancer has evolved dramatically in recent decades (1). Although total pelvic exenteration (PE) was originally performed in the 1940s as a palliative procedure in an attempt to improve the quality of life of patients with advanced cervical cancer, it now represents the treatment

Management of Locally Recurrent Rectal Cancer

Management of Locally Recurrent Rectal Cancer Zoran Krivokapic and Ivan Dimitrijevic First Surgical Clinic, Clinical Centre of Serbia Serbia 1. Introduction The treatment of colorectal canc er, that presents considerable health problem, still has a lot of space for improvement. The overall recurrenc e rate for this disease is between 8 and 50%

Progress and future direction in the management of advanced

treatment for locally advanced rectal cancer has reduced local recurrence rates. However, local failure still for re-recurrent rectal cancer, intra-operative

Local Cancer Recurrence: The Realities, Challenges, and

lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state-of-the-art treatment strategies and

Aggressive Multimodality Salvage Therapy for Locally

Recurrent rectal cancer Patients with locally recurrent rectal cancer are a hetero-geneous group: the extent of their disease, their previous therapies, and the biology of their tumors all vary widely. Similarly, the treatments they received for their initial rectal cancer may have failed for many different reasons.

Nonsurgical management of recurrent colorectal cancer

and allow earlier detection and treatment of recurrent disease. Locoregional Recurrence of Rectal Cancer Locoregional recurrence of rectal cancer is an important cause of morbidity and mortality. The risk of pelvic re- currence is directly related to the stage of the tumor. The incidence of local recurrence of rectal cancer with

Benchmarking trial between France and Australia - BMC Cancer

Keywords: Primary rectal cancer beyond total mesorectal excision plane (PRC-bTME), Locally recurrent rectal cancer (LRRC), Benchmarking study, Operative decision-making, Clinical pathway Background Over the last two decades, oncological outcomes for pri-mary rectal cancer have improved due to refinements in

Cost-effectiveness of carbon ion radiation therapy for

primary rectal cancer, the incidence of local recurrence is up to 33%. Although surgery is the mainstay of treatment for locally recurrent rectal cancer (LRRC), 70% of the patients die within 5 years following its diagnosis. Unfortunately, as a result of pel-vic wall involvement, the local recurrence is often unresectable,

[C5] Effectiveness of exenterative surgery for locally

Effectiveness of exenterative surgery for locally advanced or recurrent rectal cancer Colorectal cancer (update): evidence review for pelvic exenteration for locally ad-vanced or recurrent rectal cancer FINAL (January 2020) 8 1 N: number Quality assessment of clinical outcomes2 included in the evidence review

UCI Health Cancer Center Newport Clinical Trials

Dysfunction in Rectal Cancer Survivors Telephone Diet Modification Coaching (AIMS-RC) vs Telephone Health Education Prior history of rectosigmoid colon or rectal cancer with post-surgical permanent ostomy or anastomosis. Last date of treatment for rectal cancer (surgery, chemo, RT) must be at least 6 months, but not more than 24 months prior to

Patterns Of Distant Failure And The Impact On Survival In

Distant metastasis in advanced rectal cancer 1175 Fig. 1 Flow diagrams of the development of metachronous metastasis in patients with locally advanced and recurrent rectal cancer who had a beyond total mesorectal excision operation Patients who had a bTME resection n=220 Patients who presented with synchronous metastasis n=17 Curative treatment of

Implementation of SBRT as a Rescue Technique for

recurrence, and optimal management of locally recurrent prostate cancer after definitive radiation therapy is still challenging. In this scenario the most common retreatment option is androgen deprivation therapy, which cannot be considered as a radical treatment.

Treatment of Inguinal Lymph Node Metastases in Patients with

patients, 12 had locally advanced rectal cancer (LARC) with isolated ILNM, 3 had LARC and metastases else-where, and 2 had locally recurrent rectal cancer (LRRC). The median overall survival (OS) for all the patients treated with curative intent was 27 months [95% confidence interval (CI) 11.6 42.4 months], with a 5-year OS rate of 34%.

Clinical Nature and Prognosis of Locally Recurrent Rectal

treatment of local recurrence is quite low. The purpose of our study was to document the clinical nature and prognosis of locally recurrent rectal cancer after TME surgery, with or without short-term PRT. In addition, wetriedtoidentifypatient-,disease-,andtreatment-related factors associated with differences in prognosis. PATIENTS AND METHODS

Results of re-irradiation for pelvic recurrence in anorectal

ence local recurrence.1 3 Locally recurrent rectal cancer not only affects prognosis, but it also decreases quality of life.4 Although a standard treatment for locally recurrent rectal cancer is not established, surgical resection with negative margin is considered the primary curative treat-ment.5 7 However, radical resection is not

Patient-Derived Organoids Predict Chemoradiation Responses of

rectal excision (TME) is the standard treatment for locally advanced rectal cancer (LARC). Response prediction to NACR can help radiation oncologists before treatment to iden-tify patients with tumors sensitive to chemoradiation and may also support further treatment decision-making after NACR. MRI as well as fMRI have been used to evaluate

The effects of chemoradiotherapy on recurrence and survival

Organization for Research and Treatment of Cancer (EORTC) [4]. The diagnosis of recurrence was made on the basis of imaging studies and cytological analysis or biopsy, where applicable. Isolated local (pelvic) recurrence refers to recurrent tumor developing only in the pelvis (anastomosis, anterior-posterior-lateral pelvic wall or perineal scar).

Treatment Options According to the Clinical Stage

Recurrent Rectal Cancer Multidisciplinary Management: Type and sequence of chemotherapy, surgery, and/or radiation therapy is individualized to patient based on the multidisciplinary review. Multidisciplinary team includes: o Surgeon, o Medical oncologist, and o Radiation oncologist.

The role of carbon ion radiotherapy for unresectable locally

Background: Treatment for locally recurrent rectal cancer after surgery is still a challenge. With the physical and biological advantages, carbon-ion radiotherapy (CIRT) could be a choice for these patients. The purpose of this study was to investigate the efficacy and safety of CIRT for unresectable locally recurrent rectal cancer in Chinese

A novel approach to inoperable or recurrent rectal cancer by

Nov 09, 2015 recurrent rectal cancer remains the gold standard; several neoadjuvant treatments have been taken into consideration as treatment of locally advanced rectal cancer patients

Neoadjuvant Chemoradiation Combined with Regional

Mar 13, 2021 The HyRec trial was initially designed to optimize and standardize the treatment of locally recurrent rectal cancer (LRRC). At the beginning of the 21th century, non-resectable and especially previously irradiated local rectal cancer recurrences were usually regarded as palliative cases.

University of Groningen IORT-containing multimodality

treatment in the Catharina Hospital and the Daniel den Hoed Cancer Center: 55 patients having locally advanced primary (32 males and 23 females), and 66 patients having locally recurrent rectal cancer (41 males and 25 females). The median overall age was 63 years (range 39-86). The multimodality treatment consisted of high dose preoperative

Locally Recurrent Rectal Cancer

Locally recurrent rectal cancer includes recurrence, pro-gression, or development of new sites of rectal tumor within the pelvis after previous resectional surgery for rectal cancer.1 Patients with locally recurrent rectal cancer constitute a small group with a difficult disease that needs individualized multimodality management for optimal

Results of a pooled analysis of IOERT containing

As a result of these improvements locally recurrent rectal cancer (LRRC) has become a relatively rare disease. The 5 year local recurrence rate in rectal cancer has decreased from 20e40% to 4e8%.2 Treatment of locally recurrent rectal carcinoma repre-sents an important clinical challenge, with significant

Total Pelvic Exenteration, Cytoreductive Surgery, and

Nov 23, 2020 Pelvic exenteration is an established treatment option for locally advanced primary rectal cancer (LARC) and locally recurrent rectal cancer (LRRC), but it is associated with significant morbidity; therefore, many investigators do not recommend CRS-HIPEC with pelvic exenteration. Since the