Novel Intrapulmonary Model For Orthotopic Propagation Of Human Lung Cancers In Athymic Nude Mice

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Noninvasive Imaging for Evaluation of the Systemic

2. McLemore TL, Liu MC, Blacker PC, et al. Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice. Cancer Res. 1987;47:5132 5140. 3. Yang M, Hasegawa S, Jiang P, et al. Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression.

Novel Intrapulmonar}' Model for Orthotopic Propagation of

A similar approach for the propagation of human lung neo plasms in the lungs of athymic nude mice would appear to offer a potentially very practical and relevant model for the study of this disease. This paper describes the successful development of a novel intrapulmonary model for the orthotopic propagation of human lung cancer cells in athymic nude mice using an i.b.2 implantation technique.

'Patient-like' nude- and SCID-mouse models of human lung

human lung cancer. Thus, the usefulness of such models for basic research and therapeutic studies is limited (21). Subcutaneous-implant models have been used in athymic nude mice to study in vivo propagation of human lung cancers (22-26). These models are easy to construct but have limited applicability for developing treatment modalities

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orthotopic transplant model for human patient pleural cancer. Fresh histologically-intact patient specimens of human pleural ovarian adenocarcinoma were implanted onto the visceral and parietal pleura of nude mouse. The human tumors grew locally and regionally mimicking the usual human clinical features of this disease.