Identification Of Process Conditions Influencing Protein Aggregation In Chinese Hamster Ovary Cell Culture
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Criteria for scale-up and scale-down of bioreactors for
by B Neunstoecklin 2014 Cited by 1 operating range for parameters affecting the cell culture process. The first was derived from a Chinese hamster ovary. (CHO) host cell line and the
PDF (7 MB) - ACS Publications - American Chemical Society
by S Pérez-Rodriguez 2021 protein production in Chinese hamster ovary (CHO) cells have identification of targets related to various cellular processes.
Trends in Upstream and Downstream Process - MDPI
by P Gronemeyer 2014 Cited by 251 enormously in cell culture processes [1,2,5 8] by developing recombinant proteins are Chinese Hamster Ovary (CHO) cells [5,8,9,43,45].
Cell culture processes for biopharmaceutical - JSTOR
by M Gadgil 2017 Cited by 4 Medium and process conditions are optimized for the identified cell line to in and include Chinese hamster ovary (CHO) cells, baby.
Multiplex secretome engineering enhances - bioRxiv
24 May 2019 create a clean Chinese hamster ovary (CHO) cell by disrupting multiple genes to eliminate HCPs. Using a model of CHO cell protein
The impact of process temperature on mammalian cell lines
the Chinese hamster ovary (CHO) cell  lation initiation factors , culture process develop- ment  and the use of subphysiological temperature.13 pages
Overexpression of microRNAs enhances recombinant protein
by WP Loh 2014 Cited by 45 and low- monoclonal antibody-producing Chinese hamster ovary (CHO) cell clones using next- ture processes and thus recombinant protein production.
POSTER PRESENTATIONS PO001 - ESACT
Process Glucose Control to Influence Biopharmaceutical Protein Product Background and novelty: Chinese hamster ovary (CHO) cell culture has been
Integrating Upstream and Downstream Process Development
by LJ Wilson 2020 Effects of upstream culture conditions on mAb-associated post-protein A HCP of making these modifications such as Chinese hamster ovary (CHO) cells are.227 pages
Systematic development of temperature shift strategies for
by J Xu 2019 Cited by 21 processes that use Chinese hamster ovary (CHO) cells. metabolites, protein titer and quality depends on cell line, product,
The effect of potential large-scale bioreactor environmental
by WH Scott Within the cell, process conditions can cause aggregation by altering protein Chinese hamster ovary (CHO) cells are widely used to produce recombinant.
Screening Naturally Occurring Phenolic Antioxidants - MDPI
3 Jun 2019 diet for their effect on Chinese hamster ovary cells and the F. Identification of process conditions influencing protein aggregation.
Chapter 1 Cell Culture Process Optimization - OPUS Würzburg
by D Brühlmann 2017 Cited by 70 the focus in mammalian cell-culture process development. several rodent-derived cell lines Chinese hamster ovary (CHO) cells,
Improving culture performance and antibody - UQ eSpace
by M Buchsteiner CHO Cell Culture Processes by Reducing the Warburg Effect. Maria Buchsteiner Keywords: Warburg Effect, Chinese Hamster Ovary cells, Lactate, Pyruvate.
Cell-culture growth conditions resulting in the oxidation of a
by K Siddiquee 2019 Cited by 2 To ensure the quality of the target molecule in the cell-culture process, small-scale Chinese Hamster Ovary cells expressing the recombinant.
parallels between microbial natural products and cell culture
by AA Bandyopadhyay 2017 Cited by 17 cell line development process for recombinant protein manufacturing. d Next-gen cell line development produced using Chinese hamster ovary (CHO) cells.
Conference Program - ECI Digital Archives
13 May 2016 Kathy Chan, Conference Program in Cell Culture Engineering XV , A community genome-scale model of Chinese hamster ovary cell.
The impact of cell culture environment on CHO cell behaviour
by CH Goey Cited by 2 process indicators of CHO cell cultures and post-Protein A purification (mAb Figure 1.14 Silver-stained 2-DE pattern of Chinese hamster ovary cellular 279 pages
MONOCLONAL ANTIBODY AGGREGATION IN CELL
by EE Russell 2015 identify factors that support protein aggregation. Studies were performed using three Chinese hamster ovary (CHO) cell lines. Two were clonal.
KINETIC MODELING AND ITS APPLICATION IN THE
by P Tang 2018 In this review, we examined key factors for upstream process Keywords: Chinese hamster ovary (CHO), kinetic modeling, cell culture, therapeutic protein.
Understanding the Transcriptional Landscape of Chinese
by YK Gowtham 2016 Cited by 1 Chinese hamster ovary (CHO) cells have been used for over 25 process, we adapted a parental cell line, CHO DHFR-, and a recombinant cell line, rCHO.
Fundamental Techniques in Cell Culture - Sigma-Aldrich
nitrogen store, the identity and purity of such a cell line should be questioned in the absence of a well recorded Chinese Hamster Ovary. Fibroblast.
Process Development - Biomanufacturing.org
identified cell line that produces the product and harvest of the product. Chinese Hamster Ovary cells (CHO) and Non-Immunoglobulin Secreting mouse
N-Glycosylation optimization of recombinant - DTU Orbit
by Y Fan Cited by 3 glycosylation engineering in Chinese hamster ovary (CHO) cells. the knowledge of CHO cell culture technology, upstream process engineering, metabolic.
Investigation of the interactions of critical scale-up parameters
by M Brunner Cited by 52 Keywords CHO cell culture 4 Process parameter 4 Scale- Chinese hamster ovary (CHO) cells are the most commonly used.
An 'omics approach towards CHO cell engineering - CiteSeerX
by P Datta 2013 Cited by 140 Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells. Process.
Literature Review: CHO versus HEK Cell - Maxcyte
by K Steger changes to cell culture conditions ranging from culture stirring speed to nutrient availability can impact and SP2/0) cells, Chinese hamster ovary (CHO).
Impact of Media and Antifoam Selection on - OSTI.GOV
by SR Velugula-Yellela 2017 Cited by 25 Monoclonal antibody production in commercial scale cell culture bioprocessing protein production processes utilize Chinese Hamster Ovary.
Identification of process parameters influencing product
by AJ Paul 2015 allows quantification of mAb aggregate formation directly in cell culture samples of Chinese hamster ovary. (CHO) cells replacing falsifying
a review of the causes, implications, and potential alleviation
by H Dahodwala 2019 Cited by 28 Chinese hamster ovary (CHO) cell-based bioproduction of process, a stable cell line can be defined as a homogenous cell population that has the
Genome-wide analysis of recombinant protein - Abstracts
10 Jul 2013 tedious process of mammalian cell line development, Chinese hamster ovary (CHO) cells are currently the workhorses of the
Recombinant Protein Production Utilising a - UNSWorks
(hGH), produced by a Chinese hamster ovary (CHO) cell line utilising the pNK system at various fermentation scales and modes. As process development for CHO.
Protein Aggregation during Bioprocessing of - OPARU
by A Paul 2017 Cited by 1 influence on protein aggregation in cell cultures of Chinese hamster ovary (CHO) production cell lines. After identification of the most
PhD thesis - White Rose eTheses Online
48000 copies by YB Johari 2015 Keywords: Chinese hamster ovary cells; transient gene expression; difficult-to-express protein; aggregation; unfolded protein response; 213 pages
Investigating Media Supplements to Enhance Chinese
by B Capella Roca 2020 ammonium citrate was identified and a novel strategy to circumvent this inhibition was Fc-fusion protein in Chinese hamster ovary cell culture.
Stress Factors in mAb Drug Substance Production Processes
by TK Das 2020 Cited by 12 Chinese hamster ovary (CHO) cell culture technology is one of the ucts of the protein.2-4 Protein aggregates of every size, ranging from.
Multi-omics profiling of a CHO cell culture system - Authorea
by A Lee Chinese hamster ovary (CHO) cells are one of the main host systems used Identification of process conditions influencing protein aggre-.
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Identification of cell culture conditions to con- trol protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells. Process Biochem
Erythropoietin provides a molecular model for protein burden
by R Maldonado during'batch'culture'of'recombinant'Chinese'Hamster'Ovary'cells' can contaminate cell culture processes affecting the quality and yield of recombinant.
Characterization of Chinese Hamster Ovary Cell Performance
by J Camire However, carboxylic acids have been shown to promote an apoptotic response in CHO cell culture. Pentanoic acid is a carboxylic acid that has demonstrated lower
Identification of process conditions influencing protein
by AJ Paul 2018 Cited by 14 DOI: 10.1002/bit.26534. ARTICLE. Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
PhD thesis Maja Stressmann 2 - UWSpace - University of
by M Stressmann 2008 Cited by 2 operated at constant permeate flux using bovine serum albumin (BSA) solutions or Chinese hamster ovary (CHO) cell culture broths as feed solutions.
Development of mathematical modelling for the glycosylation
Key words: Chinese hamster ovary cells, glycosylation, IgG, mathematical modelling, 1.3.3 Influence of cultivation factors on the glycosylation 102 pages
Perfusion reduces bispecific antibody aggregation via - Nature
by P Sinharoy 2020 Cited by 1 mechanisms that influence BisAb aggregate formation in the ER. The process conditions for both CHO cell culture processes are outlined in Table 1.
Correlating composition and functionality of soy protein
by AJ Gupta Cited by 1 Chinese hamster ovary (CHO) cells are often used in cell cultures to produce biopharma- Factors affecting composition of hydrolysates.
MASS TRANSFER, MIXING, CHINESE HAMSTER OVARY
by S Sandadi 2009 Cited by 1 Consequently, an understanding of the how process conditions affect cell growth and antibody production may lead to improved process performance. Four types of
Technical application notes on cell culture and - Eppendorf
Intelligent Control of Chinese Hamster Ovary (CHO) CellCulture Using To mimick a typical protein production process, the process.
View Open Manuscript - ScienceDirect.com
by D Radhakrishnan 2018 Cited by 7 Paul AJ, Handrick R, Ebert S, Hesse F: Identification of process conditions influencing protein aggregation in Chinese hamster ovary cell culture.
Secretory leakage of IgG1 aggregates from recombinant
antibodies during the culture of Chinese hamster ovary (CHO) cells to determine how explore antibody aggregation in the CHO cell culture process.6 pages
Development of tools for monitoring and controlling cell
depending on two cell culture conditions: the pH and the lactate Chinese Hamster Ovary (CHO) and Human Embrionik Kidney (HEK293) cell lines (Estes.