Reconstruction Of The Mouse Extrahepatic Biliary Tree Using Primary Human Extrahepatic Cholangiocyte Organoids

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Artificial bile ducts grown in lab, transplanted into mice

biliary organoids. When transplanted into mice, the More information: Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids, Nature

Sampaziotis, Fotios and Justin, Alexander W and Tysoe, Olivia

1 Reconstruction of the murine extrahepatic biliary tree using primary 2 human extrahepatic cholangiocyte organoids. 3 4 Fotios Sampaziotis1,2,3, Alexander W Justin4, Olivia C. Tysoe1,2, Stephen 5 Sawiak5ƒ, Edmund M Godfrey6ƒ, Sara S Upponi6ƒ, Richard L. Gieseck III7,

Reconstruction of the mouse extrahepatic biliary tree using

reconstruction. However, the culture of primary biliary epithelium remains problematic. 7. Here we report a new method, compatible with regenerative medicine applications, for the isolation and propagation of primary human cholangiocytes from the extrahepatic biliary tree. The resulting ECOs express key biliary markers, such as cytokera-

Densified Collagen Tubes for Human Tissue Replacement

F Sampaziotis, AW Justin et al. Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature medicine 23.8 (2017): 954. OC Tysoe, AW Justin et al. Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue.

human extrahepatic cholangiocyte organoids.

1 Reconstruction of the murine extrahepatic biliary tree using primary 2 human extrahepatic cholangiocyte organoids. 3 4 Fotios Sampaziotis1,2,3, Alexander W Justin4, Olivia C. Tysoe1,2, Stephen 5 Sawiak5†, Edmund M Godfrey6†, Sara S Upponi6†, Richard L. Gieseck III7,

Edinburgh Research Explorer

culture of primary biliary epithelium10 remains problematic (7). Here we report a 11 novel method for the isolation and propagation of primary human 12 cholangiocytes from the extrahepatic biliary tree, compatible with regenerative 13 medicine applications. The resulting Extrahepatic Cholangiocyte Organoids