Macrophage Oxidation Of Low Density Lipoprotein Generates A Modified Form Recognized By The Scavenger Receptor

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VIMANG, UN POTENCIAL PROTECTOR DE LA PEROXIDACIÓN

2. Pharthasarathy S, Printz DJ, Boyd D, Joy L, Steinberg D. Macrophage oxidation of low-density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis 1986;6:505-10. 3. Endemann G, Stanton LW, Madden KS, Bryant CH, White RT, Protter AA. CD-36 is a receptor for oxidized LDL. J Biol Chem 1993;268:11811-6. 4.

LIPIDS AND ATHEROSCLEROSIS

Low-density lipoprotein (LDL) LDL is the primary plasma lipid carrier with a single apolipoprotein (apo) molecule B-100 per one particle. Apo B-100 is a 500 kD peptide chain, one of the largest known monomeric proteins, highly insolu-ble in aqeous environment, which, contrary to other apo, is not substitutable by other lipoprotein particles.

Detection of lipofuscinâ like fluorophore in oxidized human

the oxidized LDL by the scavenger receptor on macrophages. Lipid peroxidation of LDL produces various aldehydes, one of the most reactive being 4-hydroxy-2-nonenal (HNE). HNE generated during the oxidative modi¢cation of LDL has been shown to form stable non-£uorescent Michael addition-type products with the histidine and lysine residues of

Protein-bound acrolein: Potential markers for oxidative stress

sclerosis, the oxidation of circulating low-density lipoprotein (LDL) and their increased uptake by the scavenger receptor is thought to promote the deposition of lipid-laden macrophages in the vascular wall, leading to fatty streaks that precede the development of plaque (2). Lipid peroxidation proceeds by a

Structural Identification of a Novel Pro-inflammatory

LDL so that it is recognized by the macrophage scavenger/ oxidized LDL receptor rather than the native LDL receptor (13 15). Uptake of oxidized LDL by macrophages generates foam cells that reside in the subendothelial space. It is the

Effects of peroxynitrite on plasma components of the reverse

tyrosine residues [28], oxidation of thiol groups in proteins [29], depletion of antioxidants [30] and DNA oxidation and nitration [31,32]. In particular, peroxynitrite can oxidize LDL to a form which is recognized by the macrophage scavenger receptor [33], and nitrotyrosine residues have been identi¢ed in human atherosclerotic plaque [34,35].

Antisera and monoclonal antibodies specific for epitopes

cannot take up native low density lipoprotein (LDL) rap-idly enough in vitro to cause lipi1 Oxidativd loading.e modification converts LDL to a form recognized by the macrophage scavenger receptor23 an d possibly by other receptors a well,s 45 and this oxidized LDL induces foam cell formation in vitro. An increasing number of both

マクロファージによる酸化低密度リポ蛋自生成 およびマクロファージ内コレステリルエステル

of low-density lipoprotein that increase its ather-ogenicity. N Engl J Med, 320:915-924, 1989 2) Parthasathy S, Printz DJ, and Boyd D:Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis, 6:505-510, 1986

Cellular Immunity and Inflammation in Atherosclerosis

recognized as an inflammatory disease. Low density lipoprotein (LDL), the major carrier of cholesterol in plasma, is trapped in the subendothelial space, where compounds inside of LDL are chemically modified through lipid peroxidation. The oxidized LDL (oxLDL) is believed to initiate the inflammatory reaction in atherosclerosis.

Role of Cell Adhesion Molecules and Immune-Cell Migration in

in the endothelial monolayer.7 It is shown that only modified LDL can be taken by macrophages to form foam cells.8 It is believed that accumulated LDL undergoes oxidation, lipolysis, proteolysis or aggregation and that oxidation is the most significant modification for lesion initiation.2 With regards to high-density lipoprotein, it can

Macrophage oxidation of low density lipoprotein generates a

Macrophage Oxidation of Low Density Lipoprotein Generates a Modified Form Recognized by the Scavenger Receptor Sampath Parthasarathy, David J. Printz, Donna Boyd, Lorna Joy, and Daniel Steinberg Incubation of low density lipoprotein (LDL) with endothelial cells or smooth muscle