The Use Of Cyclosporin In Corticosteroid Dependent Asthma

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Atopic Dermatitis Agents: Dupilumab (Dupixent) - Washington

5 days ago Dupilumab (Dupixent) is an interleukin-4 receptor antagonist used in the corticosteroid-dependent asthma; OR 2. cyclosporine; OR.

Trial of cyclosporin in corticosteroid-dependent

by AG Alexander 1992 Cited by 445 improves lung function in corticosteroid-dependent asthmatics. After a 4-week run-in period, 33 patients with longstanding asthma (mean duration 27 years), and.

Immunosuppression in Chronic Asthma

by AG Alexander 1992 Cited by 2 Asthma. T lymphocyte. Corticosteroids. Immunosuppression. Cyclosporin A cyclosporin improves lung function in corticosteroid-dependent asthmatics [12].

Clinical response to cyclosporin in chronic severe asthma is

by AG Alexander 1995 Cited by 37 an inhibitor of T-lymphocyte activation, improved lung function in patients with chronic severe asthma. of oral cyclosporin in patients with oral glucocorticoid- dependent chronic severe asthma, cyclosporin therapy for 12 weeks resulted in a​ 

REVIEW - Bioline International

by AK Bello Cited by 3 The future management of asthma may involve the use of these newer low dose inhaled corticosteroids reduce both hospital admissions and cyclosporine can be used in some instances. Although in corticosteroid- dependent asthma.

Update on Immununosuppressive Therapies for Dogs and Cats

by KR Viviano 2013 Cited by 57 Glucocorticoids Cyclosporine Azathioprine Chlorambucil Vincristine (IMT), immune-mediated polyarthritis, and feline asthma.3 Despite the varying and example, the assays used to quantify cyclosporine blood levels vary depending on.

Therapeutic strategies for allergic diseases - Nature

by PJ Barnes 1999 Cited by 331 inhaled corticosteroids for asthma, including budesonide, flutica- sone propionate and of NF-kB are inhibited51. Cyclosporin A and tacrolimus inhibit T-lymphocyte function by tissues is dependent on adhesion of blood-borne inflammatory.

Systemic Therapy With Conventional and Novel

by K Durrani 2011 Cited by 80 agents, and antibiotics such as cyclosporine, many of which have been used in the steroid use with ocular inflammatory disease. DHFR and other folate-​dependent enzymes may (CDP840) on allergen-induced responses in asthmatic.

Severe asthma - LUMC

by EH Bel Cited by 49 Many patients with severe asthma are oral-steroid dependent. Classical steroid-​sparing drugs (gold, methotrexate, cyclosporin) are only weakly effective and have Continuous use of high-dose inhaled corticosteroids (≥1,200 g day-1 

Immunomodulatory and biologic therapies for severe - CORE

by R Polosa 2008 Cited by 28 Cyclosporin as an oral corticosteroid sparing agent in stable asthma, Issue 2, 2001; Evans DJ, Cullinan P,. Geddes DM. easily controlled by regular use of inhaled corticosteroids corticosteroid (OCS)-dependent asthma meeting our inclu-.

A placebo-controlled multicenter study of auranofin in the

by IL Bernstein 1996 Cited by 94 was 'therapeutic success or reduction of daily corticosteroid use by 50% or more Key words: Auranofin, oral gold, steroid-dependent asthma, steroid-​sparing, 

Immunomodulatory Therapy for Children with -

by CS Foster publications on the use of cyclosporin, azathioprine, and chlorambucil were also useful. asthma, or autoimmune hepatitis.18-26 However, excellent, easily usable relapsing, steroid-dependent nephrotic syndrome included cyclosporin,​.

Alternative Pharmacotherapies for Steroid-Dependent Asthma

by RB Moss 1995 Cited by 44 Key words: asthma; corticosteroids; cyclosporine; gold; immunosuppressives conclusions about MTX use in steroid-dependent asthma: (1) MTX may be a 

rapamycin - The Journal of Allergy and Clinical Immunology

by N Powell 2001 Cited by 42 function in chronic, severe, glucocorticoid-dependent asthma. The data cyclosporin A and the possible use of the newer T-cell immunomodulatory drugs​ 

Future treatments of allergic diseases and asthma

by RG Stirling 2000 Cited by 52 dependent asthma, low-dose cyclosporin-A improved lung function8 allowing for a matory effects in rheumatoid arthritis and is used as a steroid-sparing agent.

Benefits of low weekly doses of methotrexate in steroid

by R Comet 2006 Cited by 51 sparing agent in steroid-dependent asthmatic patients remains unclear. Our Pulmonary function was tested monthly during the and cyclosporin18,19.

Efficacy and safety of topical cyclosporine A 0.05% in vernal

by OE Yücel 2016 Cited by 25 for its ability to reduce corticosteroid usage and its potential as an alternative cyclosporine A (CsA) 0.05% in the treatment of VKC. METHODS A Ann Allergy Asthma trial of topical ciclosporin A in steroid dependent allergic conjunctivitis.

The Asthma Controller Step-down Yardstick - Annals of

by BE Chipps 2019 Cited by 10 be used to re-assess a current diagnosis of asthma.12,13 Consider- ations for depending on the patient's initial level of severity.1 For patients with more severe corticosteroid (ICS), and several step-down approaches may be considered: methotrexate,105 cyclosporin,106 and gold.107 Interventions with no benefit for 

omalizumab - NICE

NICE Omalizumab for the treatment of severe persistent allergic asthma severe paediatric patients dependent on long term oral corticosteroids included for the use of the other comparable treatments methotrexate, cyclosporin and gold.

Masitinib, a c-kit/PDGF receptor tyrosine kinase - AB Science

by M Humbert 2009 Cited by 140 improves disease control in severe corticosteroid-dependent asthmatics in asthma control (asthma control questionnaire), exacerbation rate, pulmonary function tests, rescue roid-dependent asthma who remained poorly controlled despite optimal asthma management. bronchial asthma with cyclosporin. Eur. Respir J 

Severe asthma guidelines - American Thoracic Society

by U Frey The methods used to develop clinical recommendations in this document follow the ATS cyclosporin A, gold salts and intravenous immunoglobulin G were studied as All studies included adult patients with corticosteroid dependent asthma 

Clinical Pharmacology of Corticosteroids - Respiratory Care

by DM Williams 2018 Cited by 70 Clinical Applications in Lung Disease. Asthma. COPD. Summary. Corticosteroids have numerous applications in treating inflammation and diseases of immune.

Topical tacrolimus for the treatment of severe allergic - SciELO

by VL Liendo 2017 Cited by 16 The use of immunomodulators, such as cyclosporin A, is reserved for cases with steroid-dependent allergic keratoconjunctivitis or when the use of patients (​72.73%), asthma in 14 (42.42%), dermatitis in 13 (39.39%), glaucoma in 6 (18.18​%) 

Current reviews of allergy and clinical immunology Update on

by HS Nelson 2003 Cited by 518 Key words: Asthma, steroid-resistant asthma, glucocorticoid, T cells Overall Purpose/Goal: To provide excellent reviews on key aspects of allergic disease to those who and-dependent (AF-2) transcriptional activation functions, as well as sites of Cyclosporin A treatment and airways inflammation in corticosteroid-.

Current and potential improvements in the treatment of asthma

by KF Chung 2002 Cited by 1 cyclosporine A and methotrexate, have been used in the treatment of steroid-​dependent asthma as corticosteroid- sparing agents.75,76 These drugs inhibit T​ 

ams 4 2012 do netu kolor:AMS 4-2005.qxd.qxd - Archives of

by J Mathew 2012 Cited by 35 Stud- ies using a daily dose of 5 mg/kg of cyclosporine have shown a beneficial effect in the treatment of steroid-dependant asthma [86, 87].


by R Madhok 1998 Cited by 1 cyclosporin A as a corticosteroid-sparing agent in corticosteroid-dependent asthma. Am J Respir Crit Care NSAIDs is a term widely used to denote agents that.

Drug Repurposing to Treat Glucocorticoid Resistance - MDPI

by AL Wang 2021 asthmatics have poor response to corticosteroid treatment [2,3]. cultured human cell lines that have been used to identify drug repurposing candidates of cyclosporin in corticosteroid-dependent chronic severe asthma.

Treatment of Severe Small Airways Disease in Children with

by A Jaffé 2002 Cited by 16 Inhaled corticosteroids are used in many centers despite the lack of conclusive cyclosporine and leukotriene antagonists, the evidence for their effectiveness comes from anecdotal patients with asthma who are corticosteroid-dependent.

Cyclosporin for steroidâ 'dependent asthma - Wiley Online

by A Szczeklik 1991 Cited by 86 We used cyclosporin to treat 12 adult patients with severe bronchial asthma who had been on systemic steroids for an average of 16 years. During the baseline 

PDF (661 KB) - ATS Journals

by SH Lock 1996 Cited by 242 asthma. We previously showed that cyclosporin A (CsA) administered for 12 wk improved lung func- pared with placebo, improved lung function in chronic cortico- Corticosteroid-dependent asthmatic patients were recruited from the out-.

The use of cyclosporin in corticosteroid dependent asthma

by ME Coren 1997 Cited by 63 The use of cyclosporin in corticosteroid dependent asthma. M E Coren, M Rosenthal, A Bush. Abstract. Five children with severe asthma requir- ing at least 10 

Asthma Therapy - Chest Journal

by JW Georgitis 1997 Cited by 3 controlled study of cyclosporin A as a corticosteroid-sparing agent in methotrexate treatment in corticosteroid-dependent asthma. Ann Intern Med 1990​; 

Safety and Efficacy of Topical 0.1% And 0.05% Cyclosporine

4 Dec 2010 And 0.05% Cyclosporine. A in an Aqueous Solution in Steroid-Dependent Vernal There are a variety of drugs currently used to treat VKC, including anti-​histamines Allergy Asthma Immunol 89: 298-303. 24. Tesse R 

Emerging Therapeutic Strategies for Asthma - JMCP

by SD Sullivan 2003 Cited by 8 function in patients with corticosteroid-dependent asthma.3, 4. Although in this study, cyclosporine and tacrolimus inhibit the activation of transcription factors.​9.

Asthma - Cleveland Clinic Journal of Medicine

ment, their use in regular maintenance therapy is under re- evaluation. Excessive use perhaps an anti-T-lympho- cyte drug such as cyclosporine may be particularly crossover study in 14 steroid-dependent asthma pa- tients. The average 

Severe Small Airways Disease Resistant to Medical Treatment

by J Davies 1996 Cited by 7 Figure 1 Deterioration in lung function with transient response to intravenous antibiotics. of cyclosporin A. Eighteen steroid-dependent, and suffers from glucose intolerance, CF(4-) and severe childhood asthma>, and has the benefit of a.

Severe asthma - PNEUMON Journal

by E Zervas 2011 Cited by 1 severe asthma treatment, but the optimal use and dosage of these drugs should be patients with corticosteroid dependent asthma, while maintaining asthma including cyclosporine, methotrexate and gold salts90-92. In general, these 

Revisiting Cyclosporine in the Age of Biologics - Practical

by T Bhutani cyclosporine A was used experimentally in transplant The use of older systemic agents, such as Myocarditis. Asthma. Grave's Ophthalmopathy. Uveitis. Nephrotic Syndrome Trial of cyclosporine in corticosteroid dependent severe.

care-mcivor-la:Layout 1 - CMAJ

by KR Chapman 2010 Cited by 6 In the past 3 years, she has used inhaled combin - ation therapy in the form of OR methotrexate OR MTX OR gold OR cyclosporin OR macrolide OR in patients with oral-steroid-dependent asthma, but is thought to do so by altering the 

2019 appendix to gina report - Global Initiative for Asthma

Low, medium and high daily doses of inhaled corticosteroids for adults and dependent effects of ICS use,204,205 underlining the need to step down treatment hematological and teratogenic effects).382 Cyclosporin383 and gold​384,385 

Phenotypes and Endotypes of Uncontrolled Severe Asthma

by P Campo 2013 Cited by 94 endotype is used to describe a subtype of a disease defined by a unique or In corticosteroid-dependent asthma, symptoms cannot be controlled, despite high 

Inhaled mometasone furoate reduces oral prednisone

by JE Fish 2000 Cited by 80 costeroid (OCS) use while retaining effective asthma control. Objective: We sought to corticosteroid dependent asthma, prednisone, glucocorticoid, health​-related quality of Agents such as methotrexate, cyclosporine, and gold salts have 

Dupilumab Use in Moderate-to-Severe Atopic Dermatitis

by ML Buck Cited by 7 Dupilumab Use in Moderate-to-Severe Atopic Dermatitis corticosteroid-​dependent asthma. cyclosporine, or other immunosuppressive.

Unconventional Treatment Options in Severe Asthma: An

by HL Banh 2011 Cited by 12 Studies on the use of macrolides in the treatment of systemic steroid-dependent asthma demonstrated that there was no significant cyclosporine should not be routinely initiated in severe asthma patients, and should only be.

prednisone - US Food and Drug Administration

These highlights do not include all the information needed to use RAYOS Cyclosporine: Increase in activity of both, cyclosporine and Asthma. Fulminating or disseminated pulmonary tuberculosis when used be broken, divided, or chewed because the delayed release of prednisone is dependent on an intact coating.

Immunomodulators, Asthma Therapeutic Class Review (TCR)

28 Jul 2020 corticosteroid-dependent asthma cyclosporine can be used; other anti-​inflammatory, immunosuppressant, or biologic agents may be.

Investigational agents for the treatment of asthma

by SE Wenzel 1998 Cited by 2 Compliance has been an issue with the use of inhaled corticosteroids because on lymphocytes).9, 10 As with methotrexate, cyclosporine should be reserved for corticosteroid-dependent asthma.11, 12 Though its mech- anism is unknown 

Cyclosporin for a severe case of aspirin-induced asthma

by E Nizankowska 1991 Cited by 15 Cyclosporin, an immunosupressive drug, predomi- Cyclosporin was used to treat a 42 yr old woman Pinis G. - Cyclosporin for steroid-dependent asthma.

Workshop summary Severe asthma in adults: What are the

by P Chanez 2007 Cited by 364 controlled with standard treat- ment, including the regular use of inhaled corticosteroids asthma, steroid-dependent asthma, brittle asthma, and so on.1 In 1999, corticosteroid ''sparing'' drugs (cyclosporine, tacrolimus, methotrexate, gold