Differential P63 And P53 Expression In Human Keloid Fibroblasts And Hypertrophic Scar Fibroblasts

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5651 Editorial Silencing or not silencing p63 in cardiac

fibroblast than in human hypertrophic scar fibroblast, whereas p53 has minor levels in keloid fibroblast. This unbalances between DNp63 and p53 with the ability of DNp63 to block p53 increases even more the oncogenic role of N-truncated isoform. In fact, DNp63 upregulation and p53 downregulation could explain the aberrant growth of keloid scars