Fertility Profile Test For Female Dogs

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and 0.05 mg/kg bw per day in dogs. The NOAEL for inhibition of brain ChE activity was 1.5 mg/kg bw per day in rats and 0.05 mg/kg bw per day in dogs. Toxicity observed in rats and dogs was limited to the characteristic muscarinic signs (salivation or vomiting) and reduced body weight gain. The


mode of inheritance of adverse factors. Test matings may be necessary and if a stud is suspected of carrying an abnormal gene a mating to a female also showing the trait is the quickest way of identifying the carrier, because the off-spring have a 1:1 chance of showing the abnormality. Age of breeding Male dogs are capable of breeding from

United States Office of Prevention, Pesticides Agency (7501C

Cyazofamid s overall toxicity profile in dogs seems to be limited. In both the 13 week and one year dog studies, there were no major toxicity findings up to a dose of 1,000 mg/kg/day. The only possible effect was increased cysts in parathyroids of both sexes and pituitary in females observed in the high dose groups of the one year study.

National Institute of Immunology, New Delhi

profile as well as antibody tires against recombinant protein in the serum. On day 65, animals should be euthanized (in saline group only one female dog will be euthanized) and gross necropsy/anatomical changes pathological analysis of all important organs, and histo-including reproductive organs should be undertaken.

P-ISSN: Momordica charantia of phytochemical study: A review

5.6 Anti fertility activity a protein in bitter melon was reported to have anti fertility activity in male rats. Oral administration of the fruit (1.7 g/day extract) to male dogs caused testicular lesions and atrophy of spermatogenic aspects. In female mice, the plant exhibited similar, but reversible, anti fertility effects.


Appropriate monitoring should be implemented in dogs under stress (e.g. post-operative) or those with hypoadrenocorticism. The response to an ACTH stimulation test may also be suppressed for several weeks after administration of osaterone. Use with caution in dogs with a history of liver disease, as safety of use of the product in these dogs

t l i- 11M 10 #S

genic in theAmestest, and notclastogenic in the humanlymphocyte assay,the mouselymphoma and in vivomicronucleustest in rats. No impairment offertility wasfound in a fertility and general reproductive performance study in mice at an oral dose 64 mg/kg/day (approximately 26 times the maximum recommended adult human daily oral dose on a Mg/M2

List of GLP Certified Test Facilities

Page 3 of 23 3291873 Fax: +91-22 66466119, 260-2707354 Email: jrf at jrfonline dot com o Sub-chronic Toxicity o Inhalation Toxicity studies o Reproductive Studies o Skin Sensitization Studies


1.5. Intended Therapeutic efficacy: Inhibition of fertility in female dogs 1.6. Dosage regimen: 1.6.1. Tested dose: 250 µg/injection/animal 1.6. 2. Route of administration: Intramuscular 1.6. 3. Duration of exposure: Each female beagle dog will receive three injections at an interval of 21 days 1.6. 4. Species: Beagle dogs (2-3 years of age) 1.7.


changes) in the female dog was 2.6 mg MBC/kg-day. In the study in which dogs were dosed with benomyl for two years, the NOEL for changes in clinical chemistry indicating hepatotoxicity was 15 mg/kg-day. The 2-year NOEL for hepatotoxicity (pericholangitis/ cholangiohepatitis) in the rat was 4.9 mg MBC/kg-day.

Ultrasound Scanning of Ovaries to Detect Ovulation in Women

The profile of hormone metabolites in early­ morning urine that was indicative of ovulation was as follows: (1) a peak in the ratio ofEl-3-G:Pd-3a-G which occurred simultaneously with, or just preceded, (2) a peak in the concentration of urinary LH, which was associated with (3) a defined in­ crease (1.5 times mean baseline of preceding three


B.20. Sex-linked recessive lethal test in Drosophila melanogaster B.21. In vitro mammalian cell transformation tests B.22. Rodent dominant lethal test B.23. Mammalian spermatogonial CHROMOSOME ABERRATION TEST B.24. Mouse spot test B.25. Mouse heritable translocation B.26. Sub-chronic oral toxicity test: 90-day repeated oral dose using rodent

Length of efficacy and effect of implant location in adult

May 14, 2019 indications (fertility control in dogs) as the 4.7 mg com-pound and twice the duration of action. The objectives of this study were to: (1) assess duration of efficacy, side effects and return to fertility in adult male cats treated with a 9.4 mg deslorelin implant; and (2) test whether efficacy and duration of action of such implants in tom

The influence of latent toxoplasmosis on women s reproductive

of latent toxoplasmosis on female fertility. We found that T. and anonymous, the obtained data would be used exclusively for gondii-infected women became pregnant at an older age, more often needed in vitro fertilisation and reported to take a from the study at any time by closing the web page.

10 Obstetrics January 15, 2007 Mother s Vitamin D Supplement

Famciclovir had no effect on general reproductive performance or fertility in female rats at doses up to 1000 mg/kg/day (2.7 to 10.8x the human AUC). Two placebo-controlled studies in a total of 130 otherwise healthy men with a normal sperm profile over an

Diisooctyl Phthalate June 2008 - Industrial Chemicals

86% was eliminated in the urine. Only about 50% had been excreted by the dogs and pigs after 24 hours, and complete elimination by dogs took 4 days and by pigs took 21 days. A small distribution to body fat occurred in all 3 species, and the investigators suggested that a slower release of DIOP from body fat and subsequent

General toxicity study designs - Europa

Dogs, Non-Human Primates, Minipigs (rabbits Studies done for most compounds in rat/rabbit →reduced fertility index and fetal viability and female/male


treatment-related findings were noted in the reproductive organs examined. The male and female fertility indices were unaffected by treatment. All pregnant females had live pups, and the duration of gestation was similar in the control and IBOMA groups. There was no effect of treatment on the mean number of live born pups or on pup death after


$ Researchers often test chemicals for their ability to change the genetic material of an organism as an indication of the chemical s potential to cause cancer. No evidence exists that lambda-cyhalothrin changes genetic material (2, 3). Humans $ The U.S. EPA classifies lambda-cyhalothrin as a group D carcinogen (25).

Ilex guayusa: A systematic review of its Traditional Uses

guayusa was tested in an in vivo model (female albino rats) shoving a remarkable increase of serum estradiol levels and ovaries and uteri weights. This finding is a preliminary but promising data in order to confirm the traditional use of I. guayusa against female infertility (24). In another study, it was observed that methanolic

Cytogenetic profile of Rajapalayam dog breed of southern India

breeds, cytogenetic profiling in dogs are of great value especially for breeders dealing with fertility problems within their pedigrees, for veterinarians and for the dog owners. No information is available on Rajapalayam dog karyological profile hence; the present study was undertaken with the objective of cytogenetic profiling of Rajapalayam

Denavir brand of penciclovir cream, 1% For Dermatologic Use

dosing at 80 mg/kg/day, or testicular effects in dogs after 13 weeks dosing at 30 mg/kg/day (575 and 845x the maximum theoretical human AUC, respectively). Intravenously administered penciclovir had no effect on fertility or reproductive performance in female rats at doses of up to 80 mg/kg/day (260x the maximum human dose [BSA]).

Figure 1. Mean Plasma Concentration Profile after a Single

Figure 1. Mean Plasma Concentration Profile after a Single Dose of 5 mg Administered to 29 Healthy Female Volunteers under Fasting Conditions Effect of Food: The effect of food administration on the pharmacokinetics of norethindrone acetate has not been studied. Distribution: Norethindrone is 36% bound to sex hormone-binding globulin (SHBG) and

Norethindrone acetate tablets, USP Rx only

6. Reduced response to metyrapone test. 4 Carcinogenesis, Mutagenesis, and Impairment of Fertility Some beagle dogs treated with medroxyprogesterone acetate developed mammary nodules. Although nodules occasionally appeared in control animals, they were intermittent in nature, whereas nodules in

crYopreservation of doG spermatoZoa: effect of bovine serum

resulted in 10 pregnancies among 11 female dogs inseminated in natural heat and the litter size ranged from 1 to 7 puppies (ANDERSEN, 1975; SZASZ et al., 2000). GUéRIN (1998), has been recommended the Osiris probe for the insemination of female dogs, even when thawed semen is used. In this case, a 10 to 15% drop in the results was observed

A New Generation - Red Angus

male or female breeding stock, or using commercial profiles in a cow/calf operation, genomic-assisted selection with today s improved testing accuracy helps producers improve with each new generation of cattle. January 2006 April 2006 May 2006 December 2007 January 2008 USDA announces completion of bovine sequence at NCBA


Skin fibromas were observed in female rats at both the high (0.4 mg/kg/day; equivalent to 4 times the exposure in humans at 1 mg)and highest (2.6 mg/kg/day; equivalent to 24 times the exposure in humans at 1 mg) doses. (see TOXICOLOGY, Carcinogenesis, Mutagenesis, Impairment of Fertility for more detailed information).

Non-Clinical Review(s)

Jun 28, 2018 Rats and dogs were administered the formulation by the nasal route during 28-day repeat-dose toxicity studies. These evaluations were meant to identify hazards that may not be observed in the small number of patients administered the product in short duration pharmacokinetic studies. There were no test article-related adverse effects on

Saroglitazar, a novel cardiometabolic agent for diabetic

was found to possess an acceptable safety profile even at doses several times higher than the approved human dose of 4 mg. Doses as high as 3 mg/kg up to 125 mg/ kg did not adversely affect mating/fertility behavior in female rats and male rats respectively. Developmental studies failed to indicate any significant adverse effect

Chlorobenzene - EPA

liver in high dose male rats was observed, but not in female rats or male or female mice. (7) EPA has classified chlorobenzene as a Group D, not classifiable as to human carcinogenicity. (5) Physical Properties The chemical formula for chlorobenzene is C 6 H 5 Cl, and its molecular weight is 112.56 g/mol. (1)

NPTN General Fact Sheets are designed to answer questions

dogs (6). See boxes on Laboratory Testing, Toxicity Category, and LD50/LC50. $ Hydroprene is low in toxicity when applied to the skin of rabbits and rats (6). $ Hydroprene is very low in toxicity when inhaled by rats (6). $ In a skin irritation studies, hydroprene was non-irritating to rabbits and mildly irritating to rats (6, 8).


dogs, no substance-related findings were observed. The NOAEL was the highest dose level tested (250 mg/kg bw). NMP showed no mutagenic/genotoxic potential in several bacterial and mammalian test systems in vitro, covering different genetic endpoints (point mutations, DNA damage and repair). In vivo no

Clinical Biochemistry Reference Ranges Handbook

Note: Test result takes minimum 2 months to return. Ref Arsenic (Bl) Normal : <0.13 μmol/L Hazardous : >0.60 μmol/L Fish, shell-fish and crustacea contain a non-toxic arsenical compound. In suspected chronic exposure sea-food is best excluded from the diet for at least 15 days prior to sample collection. Ref

Toxicological Profile for Chromium

Al-Hamood MH, Elbetieha A, Bataineh H. 1998. Sexual maturation and fertility of male and female mice exposed prenatally and postnatally to trivalent and hexavalent chromium compounds. Reprod Fertil Dev 10:179-183.


AN ABSTRACT OF THE DISSERTATION OF NAME OF STUDENT, for the Doctor of Philosophy degree in MAJOR FIELD, presented on DATE OF DEFENSE, at Southern Illinois University Car-

Animal Use for Testing Purposes - CCAC

Male and female fertility (Seg I, ICH-1) Pre and post natal development (Seg III, ICH-2) Usually done post IND FDA urges including women on clinical trials Timing is ultimately determined by the inclusion of Women of Child Bearing Potential (WOCBP) on a clinical trial Reproductive Toxicology

Naphthalene - EPA

An increased number of alveolar/bronchiolar adenomas and carcinomas were reported in female mice exposed by inhalation. (1,6,7) No carcinogenic responses were reported in rats exposed to naphthalene in their diet and by injection. (2,5,6) EPA has classified naphthalene as a Group C, possible human carcinogen. (6,7) Physical Properties

United States Office of Prevention, Pesticides Agency (7501C

fertility effects-rat Parental/Systemic NOAEL = 409 mg/kg/day in females, 1474 mg/kg/day in males LOAEL = 1624 mg/kg/day based on female decreased body weight and body weight gains. Reproductive NOAEL > 2091 mg/kg/day in males, 2239 mg/kg/day in females LOAEL = not established. Offspring NOAEL > 2091 mg/kg/day in males, 2239 mg/kg/day in females