Structural Insights Into The Regulation Of Sialic Acid Catabolism By The Vibrio Vulnificus Transcriptional Repressor NanR

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Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR of NanR, a repressor of the N-acetylneuraminate (nan) genes that NanR forms a dimer in which the two monomers create.

Evolution of cps Loci in Vibrio vulnificus - TSpace - University

by J Neiman Vibrio vulnificus is an opportunistic human and animal pathogen with the highest death rate of any foodborne disease agent. The capsular polysaccharide (CPS) 

KMB 실험실탐방 - e-생물산업

vulnificus)을 대상으로 인체에 감염시 일어나는 병원성 기전 및 선천성 면역 반응을 Park et al., The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus. Hwang et al., Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR.

Proceedings - 한국미생물학회

S1-3 10:00-10:30. Structural Insight into Toxin-Antitoxin System of Helicobacter pylori Vibrio vulnificus nan Gene Cluster for Sialic Acid Utilization. Byoung Sik 

Metabolic Engineering VII: Health and Sustainability - OSTI.GOV

by K Korpics 2012 and a mathematical model for gene regulation of metabolism addition and removal of sialic acid residues from the glycoproteins. Metabolite essentiality of Vibrio vulnificus CMCP6 for drug targeting of ZCT1 and ZCT2, TIA transcriptional repressors, coincided with the largest increase in ORCA3.

Vibrio Parahaemolyticus Interactions With Chitin In Response

by V Molina 2013 Reported infections include Vibrio vulnificus (V. vulnificus) open skin Joelsson et al., 2007), acid shock in the human stomach, detergents, of gene expression, which is sensitive to a ligand that binds to the repressor and signals is the regulation of metabolism in conjunction with nutrient levels in the environment.

A GntR-type transcriptional repressor controls sialic acid

by M Egan 2014 Cited by 15 EC101 in which the nanR gene had been cloned and overexpressed was shown to bind to two promoter regions within this cluster, each of to control sialic acid metabolism in Escherichia coli (Kalivoda from E. coli (Kalivoda et al., 2003), whereas in Vibrio vulnificus and Structural insights into the.

A Synthetic Circuit For Control Of The Bacterial Dna Damage

by J Kubiak 2018 Dissertation. Degree Name 3.3.4 Insights into the nature of the point of no return (b) Crystal structure of LexA protein bound to operator DNA adapted sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proc.

4. Publication List - (PF) at KEK

by S Arai 2013 Cited by 109 Structural Insights into the Regulation of Sialic Acid. Catabolism by the Vibrio vulnificus Transcriptional. Repressor NanR. Proc. Natl. Acad. Sci. USA, 110 (2013) 

Pyrosequencing-Based Comparative Genome - CORE

by SS Morrison 2012 Cited by 67 Between 1996 and 2006, the US Centers for Disease Control The Gram-negative bacterium Vibrio vulnificus is Genes specific to the clinical strains include components of sialic acid catabolism, regions unique to the E-genotypes, which provide initial insights into Mannitol operon repressor. N/A.

Modification and Utilization of Carbohydrates by

by C Marion 2012 Cited by 1 Sialic acid is the most common terminal modification on N- and O-linked own transcript although the reason for this remains unknown. Carbohydrate utilization regulation in S. pneumoniae 43 family repressor that regulates two operons for the transport and metabolism of Insights into the evolution of sialic acid 

KMB Lecture

Structural Insight into Exo-PETase Function of MHETase for Efficient PET Degradation. S10-4. Kyoung Heon Kim (Korea University). Biological Upgrading of 3 

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This sigma factor controls transcription of more than 150 genes The σB-controlled general stress response of B. subtilis is regulated by an thermoacetica (MtS, MtR), and Vibrio vulnificus (Vvu RsbS, Vvu RsbR) to insights into stressosome phosphorylation dynamics correlate with the factor mediated repression.

Biofilm formation of the quorum sensing model organism

by E Rabener 2015 Cited by 1 and structure as well as increased glucose levels compared to deletion Vibrio harveyi, its quorum sensing system and bioluminescence. then transcription of target genes are regulated (Bassler, 2002, Bassler and Almagro-Moreno, S. and Boyd, E.F. (2009): Insights into the evolution of sialic acid catabolism among.

Bacterial Hydrolysis of Host Glycoproteins - Karger Publishers

by J Garbe 2012 Cited by 41 regulatory aspects of bacterial glycosidases. agglutinin to sialic acid-containing glycans [12] NanH from Vibrio cholerae Enhances Cholera Toxin carbon catabolite repression (CCR) [68, 69] CCR is of genes involved in the metabolism of glycans [70] structural insights into the expanding world.

Vibrio vulnificus - UNC Charlotte

Genes specific to the clinical strains include components of sialic acid catabolism, mannitol fermentation, and a component of a Type IV secretory pathway VirB4, 

CURRICULUM VITAE - BFIC-TGU

Structural insights into the regulation of sialic acid catabolism by the. Vibrio vulnificus transcriptional repressor NanR. Proc. Natl. Acad. Sci. USA.

Mechanisms of intracellular resistance and the - UNSWorks

by GE Vergara 2019 Vibrio cholerae is the cause of the acute diarrhoeal disease cholera, and is a natural regulated by the master of virulence, ToxR, plays a key role in the release of V. surface structures (Pan et al., 2018) and internalise bacteria into phagosomes acid catabolism located in the pathogenicity island-2 (VPI-2) are present in 

VIRUSES IN THE NORTH SEA: - EPIC - AWI

by A Garin-Fernandez 2019 Family Name, Given/First Name The genome structure and possible biological functions of four in Potential Pathogenic Vibrio Species from the North Sea transcription regulation, 24 encode proteins for virion assembly and lysis, tdh) , N-acetylneuraminate lyase of the sialic acid catabolism cluster (nanA), the 

VIBRIO VULNIFICUS VIRULENCE AND SURVIVAL - Uncg

by SS Morrison 2013 genotype Vibrio vulnificus reference genomes and to identify genotype-specific phosphotransferase system component, and an operon repressor) in the We expect this effort to provide insights into structural rearrangements among the C- sialic acid u tilizatio n reg u lato r R p. iR fam ily. GO. :0. 0. 0. 5. 9. 7. 5 carb o h.

Modeling metabolism of Mycobacterium tuberculosis - WUR E

by RA Rienksma Comprehensive insights into transcriptional adaptation of intracellular Mtb metabolism was not 'genome-scale' but focused on the mycolic acid pathway,.

SOLiD sequencing of four Vibrio vulnificus genomes - DRO

by PA Gulig 2010 Cited by 55 involvement of sialic acid catabolism in pathogenesis. insight into the Vibrio-oyster relationship. However merase (NanE, VV2 0734), N-acetylmannosamine kinase VV1 0456 putative transcriptional regulator VV2 0075 anti-sigma regulatory factor specific mannitol repressor (mtlR, VV1 0640).

Dissecting regulatory mechanisms of ComA-dependent and

by E Roy 2018 regulatory proteins use to modulate the activity of the transcriptional activator ComA. Using genetic approaches, we identified additional Rap regulatory proteins 

INVESTIGATION OF A NOVEL IRON-UPTAKE SYSTEM AND

genome sequenced by our group to gain insight into the evolution and epidemiology of these emerging lineages. For microbes and humans alike, iron is an 

Transport and catabolism of the sialic acids

by AP Hopkins 2013 Cited by 32 of repression via the NanR protein (Vimr & Troy, 1985b;. Kalivoda et al. source of sialic acid in the body and there is evidence that through changes in activity of the transcription factor. NanR. regulation of the Vibrio vulnificus nan gene cluster by NanR (KDNase): structural and mechanistic insights.

Rhizobacterial salicylate production provokes - JSTOR

by PAHM Bakker 2014 Cited by 41 the ability to induce systemic resistance against diseases in plants. Exogenous lated form of the phenolic compound salicylic acid (SA), is produced (Fuster 

THE GENOME OF VIBRIO ORIENTALIS - DRUM - University

by JC Choi 2012 The genome also provided insight into nutrients that the bacterium may be Sialic acid metabolism genes in the V. orientalis genome, found on contig that these genomic structures are at least 100 kb long, and most genes encode luminescence related transcription is under the control of a repressor, and transcription 

Structural Insight Into the Bacterial Sialic Acid Catabolic Pathway

by R Caing-Carlsson 2018 zymes involved in the sialic acid catabolic and sialylation pathways. This Finally, the crystal structure of the sialic acid transporter SiaT from Proteus the down regulation of the alternative complement pathway through the yhcH and a nanR repressor located upstream. Sialic acid mediated transcriptional modulation.

Caractérisation de déterminants moléculaires du - Agritrop

by A Moumène 2015 E. canis elicit strong antibody responses, providing insight into the protective immune. 18 responses against these bacteria (Luo et al., 2009). 19. The analysis of 

Vibrio vulnificus - 저작자표시-비영리-변경금지 2.0 대한민국

by 김세근 2016 identify differentially expressed genes of V. vulnificus upon exposure to oyster. V. vulnificus CMCP6, a Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proceedings of the 

Corynebacterium glutamicum - Universität zu Köln

by A Uhde 2014 Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Proc Natl Acad Sci. U S A 110: E2829-2837 

Thesis corrected 25052016 - DTU Orbit

metabolites enabled also the gain of insights about the role of Vibrionaceae in marine ecology, with a metabolism of the marine bacterium Vibrio coralliilyticus.

Structural and Functional Characterization of the Clostridium

by MC Pélissier 2014 Cited by 10 been documented for the foodborne enteropathogen Vibrio vulnificus (10). In Clope cidated. In a further step toward providing insights into the NanE Is a Key Epimerase in Bacterial Sialic Acid Catabolism repressor NanR. Proc. sequence, and transcriptional regulation of the operon encoding a pu-.

Mechanism of NanR gene repression and allosteric - bioRxiv

by CR Hornea terminal extensions. Our data provides a molecular basis for the regulation of bacterial sialic acid metabolism. Keywords: NanR, transcriptional 

Multiple evolutionary origins reflect the importance of sialic

by N Juge The location of structurally diverse sialic acids at the cellular surface underpins the regulation of the immune system, where sialic acid contributes to the of coupled Na+ ions, and provided insight into their substrate Vibrio vulnificus YJ016 VVA1202 control by the transcriptional repressor NanR.

Comparative genomic reconstruction of transcriptional

15 Jun 2011 for fatty acid degradation) and, conversely, orthologous regulators to control distinct the transcriptional regulatory network (TRN) of the cell.

Analysis of the temperature-dependent adaptation of Vibrio

by I Montánchez Alonso 2018 99.4% amino acid identity of proteins encoded by 8 protein-coding Thus, V. harveyi uses a three-channel QS system to control the versatility of their metabolism and ability to resist many stress factors, Vibrio species pathogenic V. harveyi and demonstrated its influence on the repression of (sialic acid biosynthesis).

Carnitine and O-acylcarnitines in Pseudomonas aerguinosa

by J Meadows 2015 from the carnitine catabolism operon and we have identified the upstream yield insights into this regulation beyond Pseudomonas. inability to utilize sialic acid as a sole carbon and energy source and in vivo vulnificus pathogenesis. Repressors inhibit transcription by impeding RNAP from binding the promoter.

Mechanism of NanR gene repression and allosteric - Nature

by CR Horne 2021 Bacteria respond to environmental changes by inducing transcription of some NanR, regulates sialic acid metabolism, but the mechanism is unclear. Here Single-particle cryo-electron microscopy structures reveal the DNA-binding domain provide a molecular basis for the regulation of bacterial sialic acid metabolism.

Cooperative Regulation of the Vibrio vulnificus nan Gene

by BS Kim 2011 Cited by 47 Background: Catabolic utilization of sialic acid is essential for the pathogenesis of enteropathogens Significance: The results shed insight into the understanding of sialate metabolism gesting that NanR is a transcriptional repressor of both nan The diversity in the gene order and in the structure of nan.

Genomic signatures of sex, selection and speciation in the

by BJ Shapiro 2010 This thesis has the overarching aim of harnessing whole genome sequences to gain insight into the mechanisms of ecological differentiation in the microbial 

Regulation of Transcription of the Escherichia coli Group 2

by HAHA Owaif 2016 Cited by 3 Investigating the role of cAMP-CRP in the regulation of transcription at region 3 structures. In the case of human pathogens, different capsule serotypes have polysaccharides, especially those which include sialic acid for instance the K1 and capsular polysaccharide expression in Vibrio vulnificus, and the same study.

Spatiotemporal Regulation of Vibrio Exotoxins by HlyU - MDPI

by BS Kim 2020 Cited by 2 Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor. NanR. Proc. Natl. Acad. Sci.

EXPLORING THE ROLE OF THE MAJOR PILIN PilE IN THE

by P Kennouche 2018 For example, Vibrio cholerae Regulation of motility is coupled to environmental sensing to provide Recent structural insights provide support to the understanding of the various these appendages under the name of type IV pili became clear283,284. polysaccharides that derive from sialic acid (Figure 35a).

Structural insights into the regulation of sialic acid catabolism

by J Hwang 2013 Cited by 21 Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. Jungwon Hwanga,b vulnificus NanR is a transcriptional repressor of the nanTPSLAR. (the operon consisting of the genes 

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Lee JO, Choi SH*, Kim MH*. Structural insights into the regulation of sialic acid catabolism by the Vibrio vulnificus transcriptional repressor NanR. PNAS,.

Successful Treatment of Necrotizing Fasciitis of the Upper

Keywords: Vibrio vulni cus, Necrotizing Fasciitis, emergency debridement surgery, upper leading to severe wound infections and even septic shock, which may require amputation [2]. adhesion-related proteins and virulence regulation [3]. sialic acid catabolism by the Vibrio vulni cus transcriptional repressor NanR.Missing: vulnificus ‎ Must include: vulnificus

INVESTIGATION OF ASCORBIC ACID (VITAMIN C

by JP Rosenberger 2020 and expertise. It was always refreshing to have different perspectives, as this was L-ascorbate Catabolism and Transporter Genes Present in Vibrio. Species.

Microbe-associated molecular patterns of Aliivibrio salmonicida

on microbe-associated molecular patterns (MAMPs), structures specific to V. vulnificus exhibited up-regulation of the TonB1 and TonB2 systems, but not the metabolism were identified, including enzymes involved in sialic acid and rhamnose acting as a transcriptional repressor of iron uptake genes in the presence of 

ANNUAL CONFERENCE ONLINE 2021 - Microbiology Society

30 Apr 2021 antimicrobials are urgently required to control AMR pathogens within a insights into MmyJ, An ArsR-Like Transcriptional Repressor. Intro: Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae NanH sialidases that cleave sialic acids by hydrolyzing the glycosidic bonds to underlying sugars.