PARP Inhibitors Stumble In Breast Cancer

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ATM-depletion in breast cancer cells confers sensitivity to

by MSG Montani 2013 Cited by 73 Keywords: Breast cancer, ATM, PARP inhibitors, Olaparib, Iniparib. Background In the case of PARP inhibitors and BRCA1/2 mutations, Balmaña J, Domchek SM, Tutt A, Garber JE: Stumbling blocks on the path.

Current Status of Poly (ADP-ribose) Polymerase Inhibitors as

by DJ Hiller 2012 Cited by 28 Additionally, both TNBC and basal-like breast cancer link to BRCA mutations. The aim of this paper is to summarize the basis behind PARP inhibitors and update the current [39] M. Guha, PARP inhibitors stumble in breast cancer, Nature.

Genetics Of Chemotherapy Response In Triple - EliScholar

by C Li 2017 Triple Negative Breast Cancer (TNBC) encompasses a wide range of treatment responses therapy in TNBC and may facilitate development of targeted PARP inhibitor therapeutics. Guha M. PARP inhibitors stumble in breast cancer.

8 The BRCA patent controversies - OAPEN

by E van Zimmeren 2014 Cited by 8 breast cancers', Clinical Cancer Research, 10: 499 507. Guha, M. (2011) 'PARP inhibitors stumble in breast cancer', Nature Biotechnology, 29: 373 4.

APE1 - Repositório da Universidade de Lisboa

by PIS Guerreiro 2016 Apurinic/apyrimidinic endonuclease 1 (APE1), breast cancer therapy, DNA repair​, novel APE1 inhibitors Guha M. PARP inhibitors stumble in breast cancer.

Original Article Function and mechanism of combined PARP-1

15 Oct 2019 AB) onBRCA mutant and non-mutant breast cancer cells. Methods: Four Keywords: PARP-1 inhibitor, BRCA gene, radiosensitivity, breast cancer. Introduction [11] Guha M. PARP inhibitors stumble in breast cancer.

Enhancing the Cytotoxic Effects of PARP - Cell Press

by NE Muvarak 2016 Cited by 95 binding between DNA methyltransferases (DNMTs) and PARP1. In acute myeloid leukemia (AML) and breast cancer cells, DNMT inhibitors 

DNA Repair and Chemotherapy - Open Research Library

by S Sato 2015 Cited by 3 carriers [60]. Phase II trials of olaparib for breast or ovarian cancer associated with BRCA1/2 [107] Guha M. PARP inhibitors stumble in breast cancer. Nature​ 

Poly(ADP-ribose) polymerase inhibitors in breast cancer and

breast cancer. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) are a class of novel anticancer Why is PARP inhibition relevant in breast cancer? Prognosis and survival 41 Guha M. PARP inhibitors stumble in breast cancer. Nat.

Molecular Characterization of ERα-Positive and Triple

by TM Severson 2016 Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers. Cancer Discov. 1, 29 34.

Hereditary Breast Cancer - SAGE Journals

by MJ Larsen 2014 Cited by 91 the breast cancer-risk in BRCA1 and BRCA2 mutation carri- ers, which might PARP-inhibitors in BRCA-deficient breast and ovarian cancers.83 85 Guha M. PARP inhibitors stumble in breast cancer. Nat Biotechnol. 2011 

MSAC Application 1380 Germline BRCA mutation testing to

BRCA1 and BRCA2 are breast and ovarian cancer susceptibility genes. The BRCA1 appear to also render cancer cells susceptible to PARP inhibition are the subject of ongoing Guha M. PARP inhibitors stumble in breast cancer. Nature 

WHEN CLINICIANS AND BASIC SCIENCE RESEARCHERS

NEW APPROACHES TO FIGHTING CANCER REACH PATIENTS FASTER. THROUGH effect of PARP inhibitors on the metabolism and biology of of chromosomes and stumbled onto an to other kinds of breast cancer, TNBC (​so.

Tesaro's Parp pricing stumble and Asco sneak peek

21 Apr 2017 of Zejula lower than Clovis's rival Parp inhibitor Rubraca, this has also highlighted the fact that many negative breast and ovarian cancers.

The Case of PARP Inhibitors for BRCA1/2-Associated Canc

3 Apr 2011 Stumbling Blocks on the Path to Personalized. Medicine in concerning PARP inhibitors in BRCA-associated cancers and express concerns about challenges to Breast cancer has been the beneficiary of targeted therapies.

Non-NAD-Like poly(ADP-Ribose) Polymerase-1 - The Lancet

by C Thomas 2016 Cited by 26 or acquired resistance of tumors to known PARP-1 inhibitors poses a serious problem for their clinical implemen- triple-negative breast cancer (O'​Shaughnessy et al., 2014). PARP inhibitors stumble in breast cancer. Nat.

Single cell resolution in vivo imaging of DNA damage

by KS Yang 2015 Cited by 39 reporter, we show that not all PARP inhibitor treated tumors incur an increase in DNA damage. The inhibitor olaparib, at least in the studied xenografts of ovarian, breast Guha, M. PARP inhibitors stumble in breast cancer.

Review Article Potential biomarkers of Poly (ADP-ribose

30 May 2018 It has been observed that PARP inhibitors have optimistic antitumor activity of of PARP inhibi- tors. In 2011, PARPi stumbled in breast cancer.

The BRCA1 and BRCA2 Breast and Ovarian Cancer

2015 mutations in the breast and ovarian cancer susceptibility genes 1 & 2 (BRCA1 and BRCA2), 123-34. [157] Guha, M., PARP inhibitors stumble in breast cancer​.

Breast Cancer in Young Women - Breast Cancer Surgery

by O Gentilini Cited by 1 the role of Cox-2 inhibition on tumors arising in ribose) polymerase (PARP) inhibitors to induce a synthetic Stumbling blocks on the path to personalized.

Targeted therapies in breast cancer - Swiss Medical Weekly

by A Wickia Cited by 21 The use of both. PARP inhibitors and antiangiogenic therapy is currently hampered by a Key words: targeted therapy; breast cancer; predictive marker 52 Guha M. PARP inhibitors stumble in breast cancer. Nat Biotechnol.

Journal Club - Karger Publishers

30 Aug 2011 iniparib (I), an anticancer agent with PARP inhibitory activity, added to. GC improved 3 Guha M: PARP inhibitors stumble in breast cancer.

Single cell resolution in vivo imaging of DNA damage

by KS Yang Cited by 39 reporter, we show that not all PARP inhibitor treated tumors incur an increase in DNA damage. The inhibitor olaparib, at least in the studied xenografts of ovarian, breast Guha, M. PARP inhibitors stumble in breast cancer.

Plectin-targeted liposomes enhance the therapeutic efficacy of

by SSK Dasa Cited by 23 inhibitors. PARP inhibitors in breast and ovarian cancer patients with BRCA1/2 mutations have shown promise. About 10% of the patients who 

Investigation of Response and Resistance to PARP - -ORCA

by L Ordonez 3.2.2 Characterisation of different responses to olaparib treatment 59 breast cancer is tamoxifen, a competitive ER inhibitor; which has been very successful in patients with PARP inhibitors stumble in breast cancer. Nature 

PARP and CHK inhibitors interact to cause DNA damage and

by L Booth 2013 Cited by 55 that paRp1 and ChK1 inhibitors interact to kill mammary carcinoma cells and that Guha M. PARP inhibitors stumble in breast cancer.

Molecular features of the basal-like breast cancer subtype

by M Perou Abstract BRCA1-mutated breast cancer is associated Balman˜a J, Domchek SM, Tutt A, Garber JE (2011) Stumbling blocks on the path to personalized medicine in breast cancer: the case of PARP inhibitors for BRCA1/2-associated cancers.

A decade of clinical development of PARP inhibitors in

by J Mateo 2019 Cited by 143 eral stumbling blocks delayed the clinical development in breast cancer [35]. metastatic breast cancer comparing olaparib with physician's.

New Insights into PARP Inhibitors' Effect on Cell - Scinapse

on the cell cycle. Unlike in veliparib-treated U2OSDR-GFP cells, in olaparib-​treated cells S-phase decreased and greatest success in ovarian and breast cancers (11 14). Although data Guha M. PARP inhibitors stumble in breast cancer.

Wild card macros - Science

(5-Fluorouracil); DHFR inhibitor Methotrexate (Abitrexate); transport inhibitors Suramin M. Guha, PARP inhibitors stumble in breast cancer. Nat. Biotechnol.

Pharmacologic induction of innate immune signaling - PNAS

by LJ McLaughlin 2020 Cited by 2 DNA methyltransferase inhibitors (DNMTi) increase PARP trapping and reprogram M. Guha, PARP inhibitors stumble in breast cancer. Nat.

Synthetic Lethality in ovarian cancer, promising yet

by PM Schoonen 2011 specific importance are PARP-inhibitors, able of decapitating found to male breast cancer, prostate cancer, pancreas cancer, and melanoma (15-19). Researchers working on this subject have stumbled upon many 

PARP1 expression in breast cancer and effects of its inhibition

by J García Parra years ago, PARP inhibitors appeared as a promising therapy, particularly for patients with BRCA rational development of PARP inhibition in breast cancer. In this work we Guha, M. PARP inhibitors stumble in breast cancer. Nat Biotechnol 

July 2016 - Evaluate Pharma

31 Jul 2016 and an analysis of several Parp inhibitor products in late-stage to launch until 2019, with breast cancer the treatment's most clinically advanced punished as Arzerra stumbles in crucial pivotal trial, August 18, 2009).

the road to novel therapies for breast cancer - Endocrine

by KK Dhillon 2016 Cited by 17 2The CRUK Gene Function Laboratory and Breast Cancer Now Toby Robins Research Centre,. The Institute the key cytotoxic DNA lesion in PARP inhibitor-​exposed Balmana J, Domchek SM, Tutt A & Garber JE 2011 Stumbling blocks on.

1st UK Interdisciplinary Breast Cancer Symposium 15th

15 Jan 2018 negative breast cancer, with some indication that this treatment effect was more stated by Winston Churchill: ''Men occasionally stumble over the PARP inhibitor talazoparib (BMN 673) in mouse ES cells and human breast 

Inhibited effects of veliparib combined doxorubicin for BEL

by X Zhao 2014 Cited by 7 myeloma, breast cancer, osteosarcoma, soft tissue sarcoma and liver canceritl. for cancer around PARP, those PARP inhibitors combined with chemotherapy 

Linking off-target kinase pharmacology to the - Oncotarget

10 Mar 2014 Keywords: PARP inhibitors, off-target pharmacology, kinase profiling, drug combinations, Guha M. PARP inhibitors stumble in breast cancer.

Olaparib - Dossier zur Nutzenbewertung gemäß § 35a SGB V

8 Jul 2019 Brustkrebs-Suszeptibilitäts-Gen (Breast Cancer Susceptibility. Gene) 1, 2 Juni 2019. 7. Guha M. PARP inhibitors stumble in breast cancer.

PARP inhibitors: polypharmacology versus selective

by T Ekblad 2013 Cited by 74 We present an overview of the PARP inhibitors that have been used in clinical trials. Finally for advanced breast or ovarian cancer in patients with. BRCA1/2 mutations. Starting 70 Guha M (2011) PARP inhibitors stumble in breast cancer​.

PARP-mediated repair, homologous recombination, and back

by MJ Metzger 2013 Cited by 57 PARP inhibitors in the therapy of BRCA-deficient tumors, although [33] M. Guha, PARP inhibitors stumble in breast cancer, Nat. Biotechnol.

World's largest Science, Technology & Medicine Open Access

In the case of the hereditary BRCA1/2-deficient breast and ovarian cancer syndromes, men‐ cancer tissue, whereas the clinical success of PARP inhibitors transpired since PARP is [123] Guha M. PARP inhibitors stumble in breast cancer.

DNA repair deficiency biomarkers and the 70-gene ultra-high

results for BRCA1/2 wild-type breast cancer patients have been inconsistent. TN breast breast cancer cell line sensitivity to the PARP inhibitor olaparib; 34. (3) a 77-gene Guha, M. PARP inhibitors stumble in breast cancer. Nat. Biotechnol.

Current Management Strategies in Breast Cancer by

by S Ali 2016 Cited by 17 Keywords: breast cancer, chemoprevention, aromatase inhibitors, epidermal growth factor Guha M. PARP inhibitors stumble in breast cancer.

The role of PARP in DNA repair and its therapeutic - Nature

by M Javle 2011 Cited by 258 Inhibition of DNA repair in cancer cells represents an attractive strategy for Guha M (2011) PARP inhibitors stumble in breast cancer. Nat Biotechnol. 29: 373  

Polymerase Inhibitors as Novel Therapeutic - Hindawi.com

by DJ Hiller Cited by 28 of TNBC. Additionally, both TNBC and basal-like breast cancer link to BRCA mutations. Recent molecular basis behind PARP inhibitors and an update on [39] M. Guha, PARP inhibitors stumble in breast cancer, Nature.

View - ETD (OhioLINK)

by HC Chuang 2012 Breast caner is a heterogeneous disease and this makes breast cancer a difficult disease different different PARP inhibitors cause cell death remains unknown​. In this study, we Guha, M. (2011). PARP inhibitors stumble in breast cancer.

Novel Molecular Challenges in Targeting Anaplastic - MDPI

by A Alshareef 2017 Cited by 5 Keywords: anaplastic lymphoma kinase; ALK-expressing cancers; cancer stem cells; Guha, M. PARP inhibitors stumble in breast cancer. Nat.

PARP inhibitors stumble in breast cancer - Nature

by M Guha 2011 Cited by 139 PARP inhibitors stumble in breast cancer. Oxygen radicals. Spontaneous mutations. X-rays. Alkylating agents. Normal cell. BRCA mutation.

Updates on the Management of Breast Cancer Brain Metastases

Abstract: Breast cancer brain metastases (BCBMs) are common in patients with advanced disease. ribose) polymerase (PARP) inhibitor but subsequently