Tollâlike Receptor Signaling And IRF Transcription Factors
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Effect of tollâ like receptor 7 and 9 targeted therapy to
18/3/2014 leads to activation of the transcription factor IRF-3 which induces INF-b(12). The end result of both the MyD88-dependent and MyD88-independent TLR activation pathway is the stimulation NF-jB. Another factor implicated as one of the downstream signalling components of TLRs is the protein kinase AKT. AKT regulates a variety of cellular processes