Type I Interferons Are Important Co‐stimulatory Signals During T Cell Receptor Mediated Human MAIT Cell Activation

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Cover story First demonstration of a successful antigen

ate with innate cytokine signals during viral infectiontoactivateMAITcells.However,the role of type I interferons in regulating TCR-mediated MAIT cell activation is undefined. Inthisissue,Lamichhaneetal.demonstratea co-stimulatory role for type I interferons dur-ing TCR-mediated activation of human blood and liver MAIT cells. A role for type I

Type I interferon co-stimulation of MAIT cell function

MAITs cells via T1-IFN receptor, which MAITs express at high levels. Journal Article: Lamichane et al., 2019. Type I interferons are important co-stimulatory signals during T cell receptor mediated human MAIT cell activation. European Journal of Immunology. Article by Cheleka AM Mpande