Ephrin And Eph Receptor Signaling In Female Reproductive Physiology And Pathology

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Université de Montréal - Thèse numérique - Papyrus

oleh Y Wang 2016 In vivo, male but not female smooth muscle-specific EPHB4 knockout (KO) mice presented decreased Part I. Function and signal pathways of EPH/Ephrins this receptor family is closely related to regulating normal and pathological bone remodeling system, respiratory system and reproductive system in the KO mice.

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Thus, regulation of ephrin-B1 signaling in astrocytes may provide new therapeutic opportunities affects the Eph receptor activity in neurons. Indeed, increased 

Ephrin and Eph receptor signaling in female reproductive

oleh EA Adu-Gyamfi Dirujuk 2 kali Review. Ephrin and Eph receptor signaling in female reproductive physiology and pathology. †. Enoch Appiah Adu-Gyamfi1,2,*, Armin Czika1 

Low EphA7 Expression Correlated with Lymph Node

oleh YQ Bai 2015 Dirujuk 11 kali 1Department of Pathology, Medical College of Chifeng University, 2Research Centre of Molecular Medicine, However, the expression and significance of Eph receptors in esophageal binding site that mediates receptor-Ephrin interaction networks and other signaling systems in physiology and.

Investigating the role of ephrins and their receptors in mouse

oleh A Buensuceso 2015 Ephrins (Efn genes) and Eph receptors (Eph genes) of ephrin-A5 in female fertility, we performed a reproductive Chapter 2: The ephrin signaling pathway regulates morphology and adhesion physiology and pathology.

Molecular Aspects of Bone Remodeling - Open Research

oleh AY Parra-Torres 2013 Dirujuk 46 kali unrestricted use, distribution, and reproduction in any medium, provided the physiological mechanisms of remodeling bone, with particular attention to the role in the cell involved, the process, regulation signals into the control and pathophysiology activated by ligands called ephrins (Eph receptor interacting proteins).

EPHA2 polymorphisms in Estonian patients with age - GUP

Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Knockout of the Eph receptor A2 gene (EPHA2), which is located in Cumming RG, Mitchell P. Hormone replacement therapy, reproductive factors, and discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.

Prognostic Significance of EPHB2 Expression in Colorectal

15 Sep 2018 Contact the Korean Society of Pathologists/the Korean Society for distribution, and reproduction in any medium, provided the original work is female and two were male. JAK-STAT, ErbB, and RIG-I-like receptor signaling pathways. transcript profile: Eph receptors and ephrin ligands as molecular.

Mechanisms of cell invasion and fibrovascular - Helda

oleh E Gucciardo 2018 Eph/ephrin signalling in pathological angiogenesis MMP and receptor tyrosine kinase signalling in cancer cell invasion, physiological angiogenesis as well as in pathological vascular remodelling like tumour In females, breast cancer is predisposition, estrogen exposure, reproductive factors and lifestyle.

Tie2 and Eph Receptor Tyrosine Kinase Activation and

oleh WA Barton 2014 Dirujuk 25 kali The Eph and Tie cell surface receptors mediate a variety of signaling events during develop- ment and in the The Eph/ephrin structures are already pair and remodeling of reproductive tissues dur- ing female menstruation. genesis, the Ang-Tie system plays a role down- and, thus, may play a role in the pathology of.

Host deficiency in ephrin-A1 inhibits breast cancer metastasis

30 Mar 2020 Ephrin-A1, host-tumor interactions, breast cancer, metastasis, permits unrestricted use, distribution, and reproduction in any of receptor tyrosine kinases (RTKs), the Eph receptors, and To reflect human breast cancer, only female mice were used for Functional Roles of Eph A-Ephrin A1 System.

Pten and Dicer1 loss causes poorly-differentiated - bioRxiv

13 Mar 2020 Indianapolis, IN 46202; bDepartment of Pathology and Laboratory Classification: Biological Sciences; Physiology but without gross metastatic disease outside the female reproductive tract QPCR on dcKO uteri showed that EPH glycosaminoglycan biosynthesis, ephrin-receptor signaling, renal cell 

PHD THESIS COMPLETE 4 - TSpace - University of Toronto

oleh S Ho 3.2.6 Expression of Eph receptors and ephrin ligands in the developing forebrain Figure 1.10 Antagonistic and synergistic cross-talk with Eph/ephrin signaling 1.1 Axon guidance in mammalian central nervous system neurons following injury, as inappropriate innervation has been associated with pathological.

The osteoprogenitor-specific loss of ephrinB1 results in an

oleh A Arthur 2018 Dirujuk 9 kali The Eph/ephrin molecules originally identified in the hematopoietic system1 have bi-directional signalling between EphB4 expressing osteoblasts and ephrinB2 Animal breeding and experiments approved by the SA Pathology 129S-Efnb1tm1Sor/J (EfnB1fl/fl) female mice (JAX Laboratories, Bar Harbor, Me, USA) that 

The role of human Ephrin receptor tyrosine kinase A2 (EphA2

oleh P Subbarayal Pathology of Chlamydia Eph receptor role in physiology and disease EphA2 is an invasion and apoptosis resistance signaling receptor also The unique biphasic life cycle of Chlamydia includes a characteristic intracellular reproduction et al., Risk of sequelae after Chlamydia trachomatis genital infection in women.

EphA2-Induced Angiogenesis in Ewing Sarcoma Cells Works

oleh MG Sáinz Jaspeado 2013 Dirujuk 38 kali necessary for the right localization and signaling of the receptor to produce bFGF unrestricted use, distribution, and reproduction in any medium, provided the original author or the other class of ephrins, Eph receptors have been subdivided de Investigación del Cancer-IBMCC (15 patients) Pathology.

Download PDF - BMC Clinical Pathology - BioMed Central

oleh B Nasri 2017 Dirujuk 14 kali human epidermal growth factor receptor (HER-2) blocker ceptor (Eph) and their cell-associated ephrin ligands are reproduction in any medium, provided you give appropriate credit to the original author(s) and the BMC Clinical Pathology (2017) 17:8 Eph-ephrins bidirectional signaling in physiology and disease.

The role of the Eph and ephrin proteins in - QUT ePrints

oleh JK McCarron 2011 Eph receptor, ephrin ligand, prostate cancer, EphA2, EphA3, ephrin-A5, migration, Cell signalling studies show activation of EphA2 decreases activity of proteins The prostate is a walnut sized gland of the male reproductive system. homeostasis in the female reproductive tract, tissue maintenance and wound healing.

Transactivation of the Receptor-tyrosine Kinase Ephrin

oleh FE Lennon 2014 Dirujuk 33 kali domain within the Eph receptor facilitates forward signaling,. reverse signaling whereas excessive angiogenesis contributes to the pathology of and microvasculature in the female reproductive organs: physiological.

Endothelial cell functions - Wiley Online Library

oleh C Michiels 2003 Dirujuk 779 kali pathological processes like thrombosis, inflammation, or vascular wall remodeling. of vascular remodeling in adult, notably in the female reproductive tract. Ephrins. The Eph receptor tyrosine kinase comprise the largest signaling. Although initially characterized in the ner- vous system, ephrin A, ephrin B2, and EphB4 

EphB2 receptor tyrosine kinase promotes hepatic - Nature

oleh PN Mimche 2018 Dirujuk 14 kali ligands (Eph receptor interacting) are cell-bound molecules expressed in various Ephrin system has been described in a variety of cells and tissues in human9. 1Division of Microbiology and Immunology, Department of Pathology, This data suggest that EphB2 receptor signaling (forward signaling) is induced on.


oleh M Martinelli Integrins signalling pathways in the vascular system the female reproductive cycles (ovulation, menstruation, implantation, pregnancy) and Angiogenesis in the adult is also related to pathological situations such as tumour growth, Ephrin (Eph) receptors and their corresponding ephrin ligands are identified as the third.

EphA2 Expression Is Associated with Aggressive Features in

oleh PH Thaker 2004 Dirujuk 262 kali Center, Houston, Texas; 3Department of Pathology, University of. Iowa, Iowa City diagnosis in females and is the leading cause of death from brane proteins involved in signal transduction pathways that in normal physiology and in oncogenesis (7). family comprises 14 Eph receptors and 8 ephrin ligands (9). The.

Impressao final tese Final2 - repositorium Uminho

oleh PDP Terra 2015 Moreover ephrin B1 and eph B4 receptor mainly presented mesenchymal expressions signalling pathways interact with each other during foetal lung growth regulation. they regulate immunity, reproduction, vision and are crucial for proper Health and Physiology & Pathophysiology (adjunct), University of Manitoba.

Role of TGFβ family members on physiological angiogenesis

oleh E Alsina Sanchís 2016 1.1 Canonical TGFβ signalling pathway. 29 ALK5 receptor is present the ovarian cancer samples. 124. Figure R10. TGFβ signalling physiological and pathological situations during human life: female reproduction, tissue repair, pathways, such as the PDFG /PDGFRβ, the Ephrin/Eph, the FGFR, the Notch, the PI3K or 

Involvement of EphB4 receptor and ephrin-B2 ligand

oleh CS Chennakesava EPH RECEPTOR TYROSINE KINASES AND EPHRIN LIGANDS. 29. Structure As soon as the oocyte exits from the second meiotic arrest, the fusion of the male and the female Classical forward signal is induced when ligand binding induces kinase The Physiology of Reproduction; 441-484 Raven Press, New York.

Regulatory roles of ephrinA5 and its novel signaling pathway

oleh T Worku 2018 Dirujuk 6 kali physiological role of ephrins and Eph receptors in the regulation of mammalian The biological roles of Efna5 in mammalian reproductive cells are largely unknown. and pathological functions and most of its working principles ephrin Eph signaling in nearly all aspects of female reproduc- tion is still in 

Mutations in Chromatin Modifier and Ephrin Signaling Genes

oleh D Duran 2019 Dirujuk 21 kali 23Department of Cellular and Molecular Physiology, Yale School of example, during development, Ephrin-B2 and its receptor Eph- Limited knowledge of the molecular pathophysiology of pairing reproductive fitness. Inclusion criteria included male or female patients with clearly defined mural or.

Differential Gene Expression in the EphA4 Knockout - PLOS

oleh KM Munro 2012 Dirujuk 29 kali unrestricted use, distribution, and reproduction in any medium, The Eph receptors are the largest family of tyrosine kinases [1,2] ephrin signalling affects numerous processes in the developing mice relates to their immune system. female EphA4 knockout mice and their wild-type littermates were.

The role of syntenin-1 in modulating ephrin-b2 pathways in

oleh M Parks 2013 distribution or reproduction in any format is prohibited without the permission Eph receptor tyrosine kinases and their ligands ephrins are involved in many physiological various physiological and pathological processes in many cell types and In the developing neural system, Eph/ephrin signalling controls axonal 

EPHA4 is overexpressed but not functionally active in Sézary

oleh L Hameetman Dirujuk 6 kali distribution, and reproduction in any medium, provided the original author and source are credited. ABSTRACT. EPHA4 belongs to the largest subfamily of receptor tyrosine kinases. In addition during development of the central nerve system [16],. EPH/Ephrin signaling was shown to be involved in many.

Encyclopedia of Signaling Molecules

illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission This edition of the. Encyclopedia of Signaling Molecules is a Springer Major Reference Work that namely, their physiological and pathological roles in humans. Eph Receptor. EphA3 Ephrin Receptor A2.

A role for Notch signaling in trophoblast endovascular

oleh NM Hunkapiller 2011 Dirujuk 159 kali factors (Zhou et al., 2003; Zhou et al., 2002) and Ephrin family members that receptors that promote invasion and/or assumption of an EC-like 1Center for Reproductive Sciences, University of California, San Francisco, that placental defects involving the labyrinthian circulatory system Physiology and pathology of.

Clinical Study Expression and Function of Ephrin-B1 and Its

oleh A Sakamoto 2012 Dirujuk 6 kali 1 Department of Vascular Physiology, National Cerebral and Cardiovascular Center, Suita, We examined the expression of ephrin-B1 and its cognate receptor EphB2, key 1 female; age, 68.5 ± 2.4) who underwent vascular surgery for AAA, we obtained belong to ephrin and Eph family of genes consisting 21 mem-.

MicroRNAs As Novel Regulators of Angiogenesis - AHA

oleh Y Suárez 2009 Dirujuk 439 kali lated in the healthy adult (except for the organs of the female reproductive system) and are almost exclusively associated with pathology when angiogenesis is induced by microenvi- ronmental role for Dicer-dependent miRNAs in vascular signaling and functions Ephrin ligands and their receptors have.


oleh G Efazat 2016 From DEPARTMENT OF ONCOLOGY-PATHOLOGY. Karolinska NSCLC system we identified the Eph growth factor receptor ligand Ephrin B3 as a putative. RT target as it 4.5 Ephrin and Eph signaling in NSCLC: lessons learned in context of current women it is the second next after breast cancer [4].

Altered distribution of the EphA4 kinase in hippocampal brain

oleh AFN Rosenberger 2014 Dirujuk 31 kali The Eph receptor A4 is highly expressed in human adult hippocampal brain tissue Eph/ephrin signaling plays a role not only during synapse.

appendix 3 eph/ephrin receptor crosstalk - UQ eSpace

the development of the vascular system (Zhang and Hughes, 2006); (6) neural plasticity signalling. Both the Eph receptors and the ephrin-ligands become tyrosine in the pathological angiogenesis which accompanied tumour invasion (Gale et al., The congenital abnormality of the human female reproductive tract, 

Regulation of Ephrin-A3 expression by hypoxia through a

oleh L Gómez-Maldonado 2013 In addition to orchestrating physiological responses to hypoxia, HIF has Structure of Eph receptors and ephrin ligands (Modified from Eph/ephrin signaling is complex in several aspects. or in combination with Ephrin-A3 into 5-7 weeks old female nude mice Annual review of pathology, 2, 145 73.

Toll-like receptors (TLRs) and inflammatory bone - DiVA portal

oleh A Kassem 2015 Signaling pathway in TLR-mediated RANKL expression. 103 colony formation from bone marrow progenitors and regulated the female reproductive tract cells (111). Several physiological and pathological conditions (120, 121, 124). Eph receptors contain an extracellular Ephrin-binding region, and an intracellular.

Role of Sema3A/Neuropilin1 signaling in GnRH system

28 Mei 2013 reproductive pathologies is an inherited disorder and patients affected with this this interactions in regulation of GnRH neurons and neuroendocrine control of female The ephrins and Eph receptors in neural development.


oleh JJH Celestino 2009 Dirujuk 9 kali vivo and to maximize female reproductive potential. The present review This latter caspase leads the signaling of apoptosis to the nucleus, where an member of the ephrin family and binds both class A and ephrins and. Eph receptors in angiogenesis. ovary under normal physiological and pathological conditions.

Mutations in chromatin modifiers and Ephrin signaling

oleh D Duran 2019 Dirujuk 21 kali 24Department of Cellular & Molecular Physiology, Yale School of Medicine, New kinase Eph-B4 are exclusively expressed in either arteries or veins, these genes causing markedly impaired reproductive fitness. Mutations in the Ephrin receptor signaling pathway with rare damaging The Journal of pathology 208,.

Review Article Differential Expression Patterns of Eph - CORE

oleh CTJ Kou 2018 Dirujuk 26 kali organisms, and the physiological functions of these receptor-ligand pairs have been extensively documented in interclass binding between Eph receptors and ephrin ligands central role of Eph/ephrin signaling in axon guidance during pathological grade as well as proliferation has been observed.

Ephrin (Eph) receptor A1, A4, A5 and A7 expression - CORE

oleh C Giaginis 2014 Dirujuk 51 kali Keywords: Ephrin receptors, Non-small cell lung carcinoma, Clinicopathological To date, Eph/ephrin signaling have been considered.

The effects of Ephrin-A2 & A5 on cutaneous development

1.2.3 Ephrin ligand/ Eph receptor signalling pathology. Therefore angiogenesis such as in the female reproductive system have been reported (Gale et al., 

Human ribonuclease 1 serves as a secretory ligand of ephrin

oleh HH Lee 2021 tyrosine kinase receptor ephrin A4 (EphA4) signaling to promote breast tumor initiation in an provide a more comprehensive picture of Eph receptor regulation and shed light on potential physiological, or pathological conditions. dilution assay, 6-week-old female BALB/c nude mice were purchased from Jackson.

Mechanisms of vascular stabilization by PDGF-BB - edoc

2.1.6 Ephrins and Eph receptors signaling female reproductive cycle through a strict balance between stimulatory and inhibitory signals. semaphorins, such as Sema3A and Sema3E, are involved in physiological and pathological.

Eph Signaling in Vascular Development Thesis by Sebastian

oleh SS Gerety 2002 ephrin ligands were found to be expressed in the developing vasculature. While one To determine which Eph receptor was mediating the ephrinB2 signal, I generated a knockout of the angiogenesis, for example in the post-natal kidney and the female reproductive system Pathology International 46, 408-416. Vikkula 

Osteoimmunology - American Journal of Physiology

oleh K Okamoto 2017 Dirujuk 166 kali mones, receptors, and transcription factors. Bone cells interact with immune cells under physio- logical and pathological conditions.