Virus Studies Of Human Leukemia
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Human T-Lymphotropic Virus Types I and II
T-lymphotropic virus Type I and/or human T-lymphotropic virus Type II (anti-HTLV-I/ it is well established in studies from viral endemic leukemia.51,52 Association of HTLV-II with leukemia
Molecular cloning of aunique humanT-cell leukemia virus (HTLV
HTLVand T-cell leukemia, studies ofin vitro transmission andT-cell transformation (19) further underscore the role of this virus as a leukemogenic agent. The disease associated with this agent in mostcases canbe characterized clinically as anacuteT-cell leukemiathat hasapredisposition for skin involvement, can cause lytic bone lesions and
Hepatitis B, C, and D virus and human T-cell leukemia virus
HDV) [5 12] and human T-cell leukemia virus types 1 and 2 (HTLV 1&2) [13, 14]. Hepatitis viruses are responsible for 96% of the 1.34 million deaths related to cirrhosis and liver cancer . HBV and HDV transmission are due to the presence of the virus in biological fluids (blood, semen, and vaginal secretions) of the infected individual
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STUDIES OF SPECIFIC VIRUSES FROM GUTHRIE CARDS AND PROGNOSTIC
the development and risk assessment of childhood leukemia. Studies I and II development of childhood leukemia, a virus could still be Human herpes virus
Phylogenetic Associations of Human and Simian T-Cell Leukemia
hypothesized interspecies virus transmission in the past and in the present. The presence in monkeys and great apes of retroviruses designated simian T-cell leukemia/lymphotropic viruses (STLVs), which are related to the human T-cell leukemia/ lymphotropic virus type I (HTLV-I) (13, 23, 43, 52), has been demonstrated by seroepidemiological
Envelope Proteins of Human T-Cell Leukemia Virus: Expression
leukemia patients and healthy HTLV carriers have antibodies to the env gene products. Human T-cell leukemia virus (HTLV) (1, 2), previously also known as adult T-cell leukemia virus (ATLV) (3-5), was isolated from human T-cell lymphoma and adult T-cell leu-kemia (ATL). From molecular and epidemiological studies,
Virus studies of human leukemia
VIRUS STUDIES OF HUMAN LEUKEMIA WILLIAM H. MURPHY, PH.D., INTA J. ERTEL, M.D., AND C. J. D. ZARAFONETIS, M.D. I NDIRECT METHODS, SUCH AS ELECTRONPg AND fluorescent microscopy,8 have yielded im- portant evidence implicating viruses in the etiology of human leukemia. As a result, there is an increased urgency to isolate and char-
Seroprevalence and Molecular Epidemiology of Human T-Cell
over, most of the epidemiological studies have been performed in hospitalized patients or in individuals at risk for acquiring HTLV-1 (prostitutes, human immunodeﬁciency virus [HIV]-infected patients, etc.) or in rural populations (2, 10, 15, 34, 35). Therefore, very few data have been reported thus far for
Torque Teno Virus 10 Isolated by Genome Amplification
lecular basis of human PV, studies de-signed to detect infectious agents in human PV appear to have been ne-glected. However, studies in mice indi-cate that Friend leukemia virus can cause PV (21); perhaps, a virus also drives PV in humans and leads to subsequent ac-quisition of JAK2mutations. Furthermore, a common infectious
Replication of enhancer-deficient amphotropic murine leukemia
Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species, including humans, and is a potential contaminant in MLV vector preparations for human gene transfer studies. The generation of replication-competent virus is consid-ered less likely with vectors that delete the viral transcription elements.
ABSTRACT Title of dissertation: MATHEMATICAL AND MOLECULAR
Feline leukemia virus, strain KT, is a retrovirus that causes a fatal erythroid aplasia. The fatal loss of erythrocytes is due to the interaction of this virus with the BFU-E stage of feline erythropoietic development. This virus is comparable to the human HTLV retrovirus. Through the development of a computer mathematical model, we
Infection of Peripheral BloodMononuclearCells and Cell Cell
human chromosome 17, was a kind gift of E. Stubblefield (22). Llqis a subclone ofLi whichcontains onlythe qarm ofhumanchromosome 17 (12a). Virus stocks and assays. Purified HTLV-I virions were prepared from the growthmediaofthe virus-producing cell line MT-2,containinganHTLV-IisolatefromanadultT-cell leukemia patient (15). After the cells and
James Evermann, Professor
5. Buehring GC, et al. Bovine leukemia virus DNA in human breast tissue. Emerg. Infec. Dis 20: 772-782, 2014. 6. Erskine RJ, et al. Association between bovine leukemia virus, production, and population age in Michigan dairy herds. J Dairy Sci 95: 727-734, 2012. 7. Evermann JF, et al. Transmission of bovine leukosis virus by blood inoculation.
No Evidence of Murine Leukemia Virus-Related Viruses in Live
doubts about the association of XMRV with human disease . The origin of MLV in humans has also been questioned by the finding of reagents, human cell lines and specimens that are contaminated with MLV sequences [12,13,14,15,16,17,18]. How-ever, additional studies aimed at defining the prevalence of
Review Advances in the Study of Antitumour Immunotherapy for
can lead to temporary remission in human leukemia. It was understood at the time that the virus directly or indirectly infected tumour cells, leading to th e relief of tumour symptoms. Subsequently, a number of clinical trials began to search for viruses that could selectively lyse tumor cells with limited pathogenicity in humans.
Studies of feline leukemia virus drug susceptibility and
well as other animal retroviruses such as bovine leukemia virus and Rous sarcoma virus, led to the concepts and techniques that later enabled the discovery and characterization of human retroviruses including HIV(Levy 1993). Additionally, FeLV was 1) the first retrovirus in which a vaccine was developed,
Research on SV 40 Exposure and the Development of Cancer
In laboratory animal studies, the SV40 virus has been found to cause malignancies (mesothelioma, ependymoma, osteosarcoma, and leukemia and lymphoma) in newborn rodents, particularly hamsters, exposed to high levels of the virus (50). However, the question of whether SV40 causes human cancer is unsettled, as published data are contradictory.
Non-Hodgkin Lymphoma Causes, Risk Factors, and Prevention
Infection with human T-cell lymphotropic virus (HTLV-1) increases a person s risk of certain types of T-cell lymphoma. This virus is most common in some parts of Japan and in the Caribbean region, but it s found throughout the world. In the United States, it causes less than 1% of lymphomas. HTLV-1 spreads through sex
Bimodal high-affinity association of Brd4 with murine
virus with its IN sequence replaced with the MLV coun-terpart (3). Integration sites of the chimeric virus signiﬁ-cantly changed from active genes towards transcription start sites and thus trended closer to MLV than HIV-1. Studies of the mechanism of HIV-1 integration have elucidated a cofactor, the cellular chromatin binding
REVIEW Open Access The xenotropic murine leukemia virus
Virus could be detected through both antibodies in serum and proviral DNA in peripheral blood mononuc-lear cells (PBMCs), and could easily be cultured from PBMCs and plasma. However, although these and related studies demonstrated an association of XMRV infection with at least two human diseases, causality was not established.
and Transmission of HumanRetrovirus T-Cell Leukemia Virus)
Thus, studies with both conventional andmonoclonalantibodyT-cell markers indicate that the HTLV-positive cell lines represent matureTcells. The surface phenotype of these HTLV-producing cell lines was further characterized by using the monoclonal antibodies OKT-4, Leu-3A, OKT-8,and Leu-2A. Five of the seven lines from patients with leukemia
Bovine Leukemia Virus DNA in Human Breast Tissue
Bovine leukemia virus (BLV), a deltaretrovirus, causes B-cell leukemia/lymphoma in cattle and is prevalent in herds globally. A previous finding of antibodies against BLV in hu-mans led us to examine the possibility of human infection with BLV. We focused on breast tissue because, in cattle, BLV DNA and protein have been found to be more abun-
Role of Antibodies to Murine Leukemia Virus p15E
can intervene with the course of leukemia development as late as 5 months of age or just prior to the onset of disease progression. These findings may be relevant to the problems associated with human retroviruses, particularly ih acquired immunodeficiency syndrome (AIDS), where the immunosup-pressive aspects of virus infection are paramount (17).
Subcellular Localization of Human T-cell Leukemia Virus Type
SUBCELLULAR LOCALIZATION OF HUMAN T-CELL LEUKEMIA VIRUS TYPE 1 TAX ONCOPROTEIN Kimberly Anne Fryrear Old Dominion University and Eastern Virginia Medical School, 2008 Director: Dr. O. John Semmes Human T-cell Leukemia Virus Type 1 (HTLV-1) is a transforming retrovirus that
Human t-cell leukemia virus type 1 and strongyloides
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans.
Upregulation of Human T-Cell Leukemia Virus Type 1 Antisense
Several studies have recently demonstrated the existence of human T-cell leukemia virus type 1 (HTLV-1) antisense transcripts, which allow the synthesis of the newly described HBZ protein. Although previous reports have been aimed at understanding the potential role of the HBZ protein in HTLV-1 pathogenesis, little is
RESEARCH Open Access Natural OX40L expressed on human T cell
CXCR4-utilizing (X4) human immunodeficiency virus type-1 (HIV-1) via enhancement of production of CCR5-binding β-chemokines. It was reasoned that human T cell leukemia virus type-I (HTLV-1) immortalized T cell lines that express high levels of OX40L could serve as an unique source of physiologically functional OX40L. The fact that
Bovine Leukemia virus (BLV) and risk of breast cancer: a
human breast cancer. Another study showed that Epstein-Barr virus (EBV) infection may have a potential role in the breast cancer development, as well . Moreover, several recent studies have suggested a possible relationship between BLV (Bovine leukemia virus) and breast cancer [8, 9]. BLV belongs to the Retroviridae family. The virus is
Risk of Human T-Cell Leukemia Virus Type 1 Infection in
Future studies with a longer fol-low-up period may better quantify the risk of or both were positive for human T-cell leukemia virus type 1 (HTLV-1) were identified: 27 involving a positive
Absence of evidence of Xenotropic Murine Leukemia Virus
those of infectious diseases, many studies have investi-gated a viral etiology in CFS. However, involvement of several viruses including human herpes virus-6 (HHV-6), Epstein-Barr virus (EBV), various enteroviruses, and the human T-lymphotropic virus type 2 (HTLV-2) has not been conclusively proven [3,7-10]. In October 2009,
Risk of Leukemia after Dengue Virus Infection: A Population
caused by Epstein Barr virus, and Kaposi sarcoma caused by human herpesvirus-8 are all well-known infection-attributable cancers (2). For hematologic malignancies, examples of such causal relationships include those between human T-cell leukemia virus type I and adult T-cell leukemia, Epstein Barr virus and Burkitt lymphoma and
Bovine leukemia virus discovered in human blood
Background: Bovine leukemia virus (BLV) infection is widespread in cattle globally and is present in marketed beef and dairy products. Human infection with BLV has been reported in breast and lung cancer tissues and was significantly associated with breast cancer in 3 case-control studies. The purpose of this current research was to
WRN-targeted therapy using inhibitors NSC 19630 and NSC
Our studies suggest that targeting the WRN helicase with small inhibitors is a novel promising strategy to target HTLV-1-transformed ATL cells. Keywords: Human T-cell leukemia virus type 1 (HTLV-1), Adult T-cell leukemia/lymphoma (ATLL), WRN helicase, Cycle arrest, Apoptosis Background Human T-cell leukemia virus type 1 (HTLV-1) is a retro-
EVIDENCE FOR HUMAN T CELL LYMPHOMA-LEUKEMIA VIRUS INFECTION
evidence for human t cell lymphoma-leukemia virus infection of family members of human t cell lymphoma-leukemia virus positive t cell leukemia-lymphoma patients by marjorie robert-guroff, v s. kalyanaraman, william a. blattner, m. popovic, m. g. sarngadharan, michiyuki maeda~ douglas blayney, daniel catovsky,
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very similar to the virus-associated DNA polymerase obtained from myeloblasts and MC29 infected CEC. Possible mechanisms for RNA tumor virus replication are dis-cussed. Evidence for human tumor virus etiology of human leukemia is presented.
Viruses and mycoplasma (PPLO) in human leukemia
to the study of human leukemia. The observa- tion of characteristic virus particles, similar to those of mouse leukemia virus particles, in the cells of a lymph node obtained by surgical biopsy from a 15-year-old girl with acute leu- kemia,20 has led to tissue culture and electron microscope studies of biopsy specimens from
Immunologic Aspects of Leukemia Virus Research in Humans
acute lymphocytic leukemia, or breast cancer gave positive reactions. A second test, inhibition of the paired radioiodine-labeled antibody technique, confirmed the results with sera from patients with rhabdomyosarcoma. The results are interpreted as serologic evidence of a human RNA-tumor virus. Other types of evidence for human RNA-tumor
No evidence of xenotropic murine leukemia virus-related virus
human infection and virus transmission in case of inadvertent exposure and infection. Due to the undeﬁned pathogenic poten-tial of XMRV, the unexpected discovery of the virus or its se-quences in some cell lines used broadly in research, and broad contamination of laboratory reagents with murine leukemia virus
Human T-cell Leukemia Virus Type 1 Molecular Variants
The 4 new human T-cell leukemia virus type 1 (HTLV-1) sequences (VAN 54, VAN 136, VAN 251, VAN 335; GenBank accession nos. AY549879, AY549880, AY549881, AY549882) were analyzed with 126 HTLV-1/simian T-cell leukemia virus type 1 (STLV-1) sequences available from the GenBank database.