Rational Targeting Of Notch Signaling In Cancer
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Rational targeting of Notch signaling in cancer - Nature
by P Rizzo 2008 Cited by 421 Interest in therapeutic modulation of the Notch pathway has been increased by recent reports, indicating that its role is important in controlling the fate of
Original Article A peptide derived from D. melanogaster
30 Jan 2021 Negative regulation of Notch pathway on mammary cancer cells B and Miele L. Rational targeting of Notch sig- naling in cancer.
Clodia Osipo Publications BeLow M, Osipo C. Notch Signaling
29 Sep 2020 BeLow M, Osipo C. Notch Signaling in Breast Cancer: A Role in Drug Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in.
Targeting the Notch signaling pathway in cancer therapeutics
by H Guo 2014 Cited by 41 Cancer; Notch signaling pathway; oncogene; targeted therapeutics; tumor suppressor gene. Correspondence. Jian Zhang or Qinghua Zhou, Guangxi Medical.
Maquetación 1 - Digitum
by R Beschorner 2013 Cited by 8 Notch signaling can act as an inhibitor of apoptosis. (Perumalsamy et al., 2009) or promote and challenges for Notch-targeted therapies in oncology.
Inhibiting Notch Activity in Breast Cancer Stem Cells by - Pure
by V Mamaeva Cited by 79 Targeting Notch in Stem Cells With Nanoparticles. Figure 3 Tumors with hyperactive Notch signaling show enhanced glucose uptake.
Co-Expression Analysis Reveals Mechanisms Underlying the
by SL Sinicropi-Yao 2019 Cited by 7 of rational NOTCH1 pathway-dependent targeted thera- pies for specific tumor subsets Keywords: Lung cancer; Notch; Co-expression; Immune.
MicroRNA-582-5p suppresses non-small cell lung - PLOS
by J Liu 2019 Cited by 15 Non-small cell lung cancer (NSCLC) is the most common cancer worldwide. The Notch signaling pathway, a highly evolutionally conserved
Notch-1 and IGF-1 as Survivin Regulatory Pathways in Cancer
by CWC Lee 2008 development of rational targeted cancer therapeutics. Nodal proteins are critical Targeting Notch signaling for breast cancer therapy
lncRNA - Jefferson Digital Commons - Thomas Jefferson
by S Liu 2016 Cited by 44 Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 2008; 27:5124 5131. [PubMed: 18758481].
Notch Signaling Activation in Pediatric Low-Grade Astrocytoma
by WD Brandt 2015 Cited by 10 ventional therapies (i.e. chemoradiation), novel rational targeted therapies based on our increasing knowledge of the biology of these tumors are needed.
Targeting Notch, Hedgehog, and Wnt pathways in cancer
by N Takebe 2015 Cited by 903 designing clinical trials that target CSCs with rational combinations of logy is twofold: on the one hand, targeting Notch signal-.
Rational targeting of Notch signaling in breast cancer
by L Miele 2008 Cited by 31 rational targeting of Notch signaling in breast cancer will and Notch-4 [15,16] cause mammary tumors in transgenic mice.
Notch1 induces epithelial-mesenchymal transition and the
by X Zhang 2015 Cited by 47 Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-5131, 2008. Figure 6. Notch1 promotes tumor growth in vivo.
THE TUMOR SUPPRESSOR NOTCH INHIBITS HEAD AND
by S Moorthy 2015 Cited by 1 mice orthotopic model of oral cancer. An unbiased gene expression analysis was performed to identify potential downstream targets of the NOTCH pathway.
From Fly Wings to Targeted Cancer Therapies: A - Cell Press
by P Ntziachristos 2014 Cited by 325 In this review, we discuss the protumorigenic and tumor-suppressive functions of Notch signaling, and dissect the molecular mechanisms that
GRANT SNAPSHOT 2004 Pancreatic Cancer Action Network
goals focus on the identification and preclinical validation of rational, cancer-specific Notch signaling has been found in several human cancers.
Download PDF - SAGE Journals
by C Hicks 2011 Cited by 9 major oncogenic pathway in breast cancer, the Notch signaling pathway. Miele L. Rational targeting of Notch signaling in breast cancer. Expert Rev.
Notch signaling from tumor cells - Cell Press
by JL Li 2005 Cited by 155 three downstream targets (Hey1, -2, and -L). Selective interruption of Notch signaling within tumors may provide an antiangiogenic strategy. Figure 1.
Top Notch Targeting Strategies in Cancer: A Detailed - MDPI
by G Moore 2020 Cited by 25 Notch has been shown to antagonise WNT/β-catenin signalling pathway in progenitor and stem cells, through a post-translational suppression of
Estrogen receptor Î²â - Journal of Biological Chemistry
8 Apr 2017 effects both endothelial cells apoptosis and Notch signaling, we (2008) Rational targeting of Notch signaling in cancer. Oncogene 27,.
NOTCH SIGNALING REQUIEM - KI Open Archive - Karolinska
by YL Tsoi 2020 multiple cancer cell types. By siRNA knocked down of HIF2α, we found that Notch signaling requires HIF2α for regulating a subset of Notch targets in
The Regulation of Notch Signaling by Src Kinase and
by BD LaFoya 2018 Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 2008;27(38):5124-5131.
associated Mutant Notch1 and Depletes Therapy Resistant
by A Sharma Cited by 28 are being developed to block Notch signaling in cancer cells, the most prominent importance of targeting Notch1 signaling to overcome
Pharmacological disruption of the Notch transcription - PNAS
25 Jun 2020 The Notch signaling cascade is one example of a pathway that has emerged as a rational therapeutic target in several cancers.
Intratumoral heterogeneity of Notch1 expression in small cell
In lung cancers, Notch exhibits both tumor-promoting and -suppressive functions depending on the histological type (14). Notch signaling is an essential
chronic lymphocytic leukemia in the times of - Haematologica
by A Ring 2020 Current approaches targeting Notch signaling include γ- Department of Medical Oncology and Haematology, University Hospital Zurich and University of
Breast Cancer Now-funded Manchester Breast Centre
Medical Center Rational targeting of Notch signaling in breast cancer 27. April 2010. 15.Professor Lars Holmberg, Division of Cancer Studies,
Dose-dependent induction of distinct phenotypic - PNAS
by M Mazzone 2010 Cited by 166 Notch pathway activation in 3D cultures of MCF-10A mammary epithelial cells. (2008) Rational targeting of Notch signaling in cancer.
Linking model systems to cancer therapeutics - Disease
rational targeting of Notch signaling, designed to downregulate its activity during oncogenesis, is a very active area of study (Rizzo et al., 2008).
Diallyl Trisulfide Modulates Notch Pathway Components in
by V Kiesel 2016 that targeting Notch ligands and alpha secretases is clinically relevant in breast cancer patients. Efforts to inhibit Notch signaling in cancer patients
Targeting gamma secretase - Annals of Oncology
by EEI Dumbrava 2018 Cited by 3 Notch signaling is a highly conserved pathway with critical roles cogenesis and cancer progression, angiogenesis and in shaping.
Aberrant activation of Notch signaling in extrahepatic
by S Aoki 2016 Cited by 18 therapeutic strategy for targeting cells with CSC-like properties. Keywords: Notch signaling, Cholangiocarcinoma, Hes-1, Cancer stem cell.
Notch Signaling Pathway as a Therapeutic Target in Breast
22 Oct 2010 In murine mammary cancers, the Notch 4 locus is a Concurrently, targeting both the notch pathway and the.
Download PDF - Breast Cancer Research - BioMed Central
by J Han Cited by 72 Is Notch signaling aberrantly activated in breast cancer? Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L: Rational targeting.
Dose-dependent induction of distinct phenotypic - JSTOR
by M Mazzone 2010 Cited by 167 Notch pathway activation in 3D cultures of MCF-10A mammary epithelial cells. (2008) Rational targeting of Notch signaling in cancer. Oncogene 27:.
Notch Pathway Is Activated by MAPK Signaling and Influences
by AS Yamashita 2013 Cited by 82 Notch signaling plays a role in PTC cell proliferation. Conditional induction of MAPK Rational targeting of Notch signaling in cancer.
Notch signaling - CORE
by X Yuan 2015 Cited by 295 Notch signaling: An emerging therapeutic target for cancer treatment hibitors targeting the Notch pathway, including gamma-secretase.
Secretase Inhibitors in Cancer Treatment - The Oncologist
by P López‐Nieva 2021 Cited by 2 to interest in inhibiting NOTCH1 signaling as a therapeu- tic target in cancer. Rational targeting of Notch signaling in cancer. Oncogene.
NOTCH SIGNALLING MODULATES HYPOXIA-INDUCED
by G Danza 2011 Cited by 68 Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 2008; 27:5124 31. [PubMed: 18758481].
Rational Targeting of Notch in Breast Cancer - ResearchGate
Abstract. The importance of Notch signaling in solid tumors and particularly breast cancer is being increasingly appreciated. This has led to the development of
Therapeutic approaches to modulating Notch - DanStem
30 Jan 2012 Dysregulated Notch signaling has been implicated in numerous human diseases GSIs for Notch-targeted cancer therapeutics: T-ALL and other
Notch Signaling Pathway in Carcinogenesis
ing . Many of the Notch target genes are impli- cated in targeted combination therapy of several different types of cancer. Notch signaling func-.
Targeting Notch trafficking in human cancer cells: - AIR Unimi
by KF Mung athia V-ATPase inhibition suppresses Notch signaling in breast cancer cells By removing Notch receptors from the cell surface and targeting them for.
Translational and Therapeutic Implications of the Notch
by RA Previs 2014 Cited by 134 approved therapies currently exist for the Notch pathway, mul- rational, biologic explanation for why targeting Notch ligands may.
Exploitation of the Notch Signaling Pathway as a Novel Target
by Z WANG 2008 Cited by 124 chemopreventive agents that could be useful for targeted inactivation of Notch signaling, which could become a novel approach for cancer prevention and
IER5, a DNA damage response gene, is required for - eLife
by L Pan 2020 Cited by 2 Abstract Notch signaling regulates squamous cell proliferation terns of Notch mutations that are found in different cancers (for
Survivin upregulation, dependent on leptin EGFR Notch1
leptin signaling and breast cancer was first established Miele L 2008 Rational targeting of Notch signaling in breast cancer.
Targeting Notch Trafficking and Processing in Cancers - MDPI
by L Pagliaro 2020 Cited by 2 The canonical Notch signaling pathway initiates in response to NOTCH ligands. The strength of receptor ligand interactions and the fate of the
LNX1 Modulates Notch1 Signaling to Promote - bioRxiv
by AU Ahmed 2020 Cited by 2 chemotherapy, LNX1-regulated Notch1 signaling promotes stemness and Rizzo, P., et al., Rational targeting of Notch signaling in cancer.