Long‐term Outcome Of Japanese Patients With Type 1 Autoimmune Hepatitis

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for Japanese chronic hepatitis C patients with normal alanine aminotransferase Significance of lgG4-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of lgG4 reaction in cancer tissue An inadequate dose of ribavirin is related J Infect Chemother.2012 to virological relapse by chronic hepatitis Blood. 2012 Blood. 2012 jul

Hepatic Medicine: Evidence and Research Dovepress

the former having a worse outcome.44 Interestingly, AIH can be present in 10% of patients affected by autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, also known as autoimmune polyendocrine syndrome type 1, which is caused by homozygous mutations in the AIRE1 gene, a transcription factor involved in clonal deletion of self reac-

Autoimmune Hepatitis: A Risk Factor for Cholangiocarcinoma

diagnosis of cholangiocarcinoma in auto-immune hepatitis. World J Gastrointest Endosc 2010;2:404 407. 8 Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, et al: Long-term outcome of Japanese patients with type 1 autoimmune hepatitis. Hepatology 2012;56:668 676. 9 Chapman RW: Risk factors for biliary tract carcinogenesis.

Thrombotic thrombocytopenic purpura in a patient with rapidly

of 7.4 g/dL, albumin of 2.6 g/dL, blood urea nitrogen of 40 mg/dL, and serum creatinine of 6.02 mg/dL. In addi-tion, her CRP level was 25.9 mg/dL, while the rheumatoid

Nonalcoholic fatty liver disease and cardiovascular disease risk

tests for viral and autoimmune liver diseases. It usually has a benign clinical course, but it may progress to NASH, fibrosis, cirrhosis, and rarely to hepatocellular carcinoma [1,2]. The term NASH was introduced by Ludwig et al. [3] in 1980, who reported 20 moderately obese patients with liver biopsy changes resembling alcohol-induced hepati-

CASE REPORT Open Access Histiocytic necrotizing lymphadenitis

significantly more frequent in Japanese patients with HNL [5]. Viral agents (human herpes virus 6 and 8, Epstein-Barr virus, parvovirus B19, human T-lymphotropic virus type-1), bacteria and protozoa have all been implicated in the etiology but the supportive data are controversial [2]. Physicochemical factors (pacemaker implantation, sili-

大阪医療センター - 国立病院機構大阪医療センターでは、三大疾患である、がん・心臓病・脳卒中をはじめとして、広い領域の疾患

outcome in response-guided pegylated interferon plus ribavirin therapy among patients with hepatitis C virus genotype 1. Gastroenterol. 2013 May 21. [Epub ahead of print] Ishida H, Sakane S, Toyama T, Fukutomi K, Kimura K, Sugimoto A, Hibino K, Tamura T, Iwasaki T, Iwasaki R, Hasegawa H, Sakakibara Y, Yamada T, Nakazuru S, Mita E.

Liver Pathology Symposium

Alpha-1-Antitrypsin Two main variants; S (60% of wild type) ~ 6.2% prevalence, Z (10% activity) ~ 2.7% Homozygous PiZZ clear disorder with emphysema and cirrhosis? Role of Heterozygous in chronic liver disease CUH study >1000 pts OLT assessment IsoElectricFocusing and/or histology (PASD & IHC PiZ) Cacciotolo, Eu J Gas &Hep, 2014

Correlation of Histopathological - Hepatitis Journals

patients who showed histopathological changes of steatosis in at least 5% of hepatocytes and whose daily alcohol intake was <20 g/day. We excluded patients with 1) underlying liver disease such as viral hepatitis, autoimmune hepatitis, drug-induced liver disease, or primary biliary cirrhosis; 2) underlying systemic

ISPUB

The term autoimmune pancreatitis (AIP) was first proposed by the Japanese in 1995 (Yoshida et al., 1995) who described a case of steroid-responsive pancreatitis. Type 1 AIP is also known as lymphoplasmacytic sclerosing pancreatitis. It is an uncommon condition, accounting for 2% of chronic pancreatitis cases (Zen et al., 2011). The major

CASE REPORT Autoimmune haemolytic anaemia in a newborn infant

3 Win N, Kaye T, Mir N, et al. Autoimmune haemolytic anemia in infancy with anti-Kpb specificity. Vox Sang1996;71:187 8. 4 Satake N, Nakanishi M, Okano M, et al. A Japanese family of X-linked auto-immune enteropathy with haemolytic anemia and polyendocrinopathy. Eur J Pediatr1993;152:313 15.

Serum Wisteria floribunda Agglutinin-Positive Mac-2-Binding

Study of Liver Diseases ( 3 ). All patients were treated with UDCA (10 13 mg/kg per day). Forty-fi ve healthy subjects with nor-mal liver function tests served as controls. In addition, 40 Japa-nese patients with type 1 autoimmune hepatitis were adopted as comparison cases having another autoimmune liver disease. All

SGLT2 Inhibitor Treatment Outcome in Nonalcoholic Fatty Liver

In this retrospective study, 7 Japanese patients with NAFLD and T2DM received long-term treatment with 100 mg canagliflozin/day at our hospital between November 2015 and December 2019, and the clinical and histopa-thological effects (e.g. steatosis, lobular inflammation, bal-looning, and fibrosis stage) of such long-term treatment

Autoimmune hepatitis on the rise - Journal of Hepatology

[12] Kanzler S, Lohr H, Gerken G, Galle PR, Lohse AW. Long-term management and prognosis of autoimmune hepatitis (AIH): a single center experience. Z Gastroenterol 2001;39:344 348. [13] Yoshizawa K, Matsumoto A, Ichijo T, Umemura T, Joshita S, Komatsu M, et al. Long-term outcome of Japanese patients with type 1 autoimmune hepatitis.

INTERLEUKIN 28B GENE POLYMORPHISMS AS A PREDICTOR OF

Aim of the work: This study is designed to identify IL28B gene polymorphisms in patients with chronic hepatitis C genotype 4 who received standard of care therapy to highlight its impact on

2020 Annual Update in Medical Hepatology

32 patients with PSC underwent LT (of 2268 LTs from August 2004 to July 2018) Mean MELD at time of lT was 19 25% had UC Almost all underwent hepatico-J Recurrence was seen in 20% at mean f/u of 5 years Five patients died at f/u 4 sepsis, 1 recurrent PSC

Optimizing management in autoimmune hepatitis with liver

Ciardullo M, et al. Fulminant autoimmune hepatitis type 1: Clinical presentation, outcome and prognostic factors. (Ab-stract 480) AJT 2005; 5 (Suppl 11): 278 23 Kessler WR, Cummings OW, Eckert G, Chalasani N, Lu-meng L, Kwo PY. Fulminant hepatic failure as the initial presentation of acute autoimmune hepatitis. Clin Gastroen-terol Hepatol 2004

Long-Term Consequences of Child Abuse and Neglect

Some long-term physical effects of abuse or neglect may occur immediately (e.g., brain damage caused by head trauma), but others can take months or years to emerge or be detectable. There is a straightforward link between physical abuse and physical health, but it is also important to recognize that maltreatment of any type can cause

Hepatic Venous Outflow Obstruction in Pediatric Living Donor

(n ¼ 3), and autoimmune hepatitis (n ¼ 1). The recipient operation was performed in a piggy-back fashion without venovenous bypass, as described elsewhere.1 The anastomotic orifice was prepared according to the number of graft hepatic veins, the shape of the graft, and the anatomy of the recipient IVC.6,10 The standard type of recipient

Mutations in E2-PePHD, NS5A-PKRBD, NS5A-ISDR, and NS5A-V3 of

The patients showed no evidence of hepatitis B virus-infected, alcoholic, autoimmune, or drug-induced liver disease. Patients who obtained normalization of alanine aminotransferase levels and

Fatal outcome in a patient under immunosuppressant therapy

the fatal outcome [11]. CMV is an important oppor-tunistic pathogen that causes morbidity and mortality in immunocompromised patients, leading to symp-toms such as fever, interstitial pneumonia, enteritis, hepatitis, retinitis, and encephalitis. CMV infection can be assessed through a variety of techniques, in-

Effect of interferon therapy on the incidence of

The effect of interferon on the long-term clinical outcome of patients with chronic hepatitis C remains unclear. This study included 594 patients with chronic hepatitis C who received interferon-a therapy (Interferon group) and 144 patients with chronic hepatitis C who did not receive inter-feron (Control group). The patients in the Interferon

A 欧 文

19. Isomoto H, Inoue K, Kohno S: Interleukin-8 levels in esophageal mucosa and long-term clinical outcome of patients with reflux esophagitis. Scand J Gastroenterol 42: 410-411, 2007( IF: 1.758)*

ABNORMAL LIVER TESTS

Hepatitis B: Can be acute or chronic History: Patient from Asia, Subsaharan Africa; sexual history, drug use Labs: ALT/AST, Hepatitis B surface antigen, Hb core antibody Hepatitis C: History: IV drug abuse, blood transfusion prior to 1992, sexual history, tattoos Labs: Hepatitis C antibody (HCV viral load if immunocompromised)

SGLT2 Inhibitor Treatment Outcome in Nonalcoholic Fatty Liver

In this retrospective study, 7 Japanese patients with NAFLD and T2DM received long-term treatment with 100 mg canagliflozin/day at our hospital between November 2015 and December 2019, and the clinical and histopa-thological effects (e.g., steatosis, lobular inflammation, bal-looning, and fibrosis stage) of such long-term treatment

Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. (3): 387-390, May

The number of patients with secondary immu-nodeficiencies has increased rapidly in the last three decades. This is secondary to the improvement in cancer treatment, the use of immunosupressive drugs in autoimmune diseases and transplants, and mainly due to HIV infection (CDC 1991, Ljungman 1995). Immunocompromised patients are at a high risk

Analysis of the factors motivating HCV-infected patients to

Japanese hepatitis C virus (HCV)-infected patients tend of occurrence of HCC and to improvement in long-term prognosis [3-6]. In view of the current circum- (Table 1). All patients were admit-

Myocarditis in Childhood: An Update on Etiology, Diagnosis

has been more commonly documented in Japanese patients and parvovirus B19 is more frequently detected by PCR in German popula tion (Magnani & Dec, 2006). Matsumori et al found that hepatitis C virus infection is often found in cases with dilated cardiomyopathy and that hepatitis C virus have an crucial role in the pathogenesis of cardiomyopathy

Minocycline Induced Autoimmune Hepatitis And Systemic Lupus

1 R v Cambridge HA, ex p B judgment [1995] 2 All ER 129. 2 Smith R. Rationing: the debate we have to have. BMJ 1995;310:686. 3 Hall C, Mackinnon I. Cancer girl loses fight for treatment Independent 1995; 11 March: l,col4. (Accepted 11 October 1995) Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome

CASE REPORT HEMOPHAGOCYTIC SYNDROME ASSOCIATED WITH HEPATITIS

anemia or pure red cell aplasia related to hepatitis A14,43. These and other extrahepatic manifestations of HAV infection may be more common in patients who have protracted disease, such as relapsing or cholestatic hepatitis37,38. Cholestatic form of HAV infection is usually characterized by marked jaundice, pruritus, fever, weight loss and

Risk Factors for Recurrence of Primary Sclerosing Cholangitis

rPSC,2chronicrejection,1multiplehepaticinfarction,1de novo autoimmune hepatitis, 1 ABO-incompatibility-related cholangitis,1chroniccholangitis,4unknown),eightdiedof infection, four of multiple organ failure, three of cancer (2 cholangiocarcinoma and 1 carotid gland cancer) and four of unknown causes. Sixteen patients underwent retransplan-tation.

先進感染制御学分野 - mdp.nagasaki-u.ac.jp

19. Isomoto H, Inoue K, Kohno S: Interleukin-8 levels in esophageal mucosa and long-term clinical outcome of patients with reflux esophagitis. Scand J Gastroenterol 42: 410-411, 2007 (IF: 1.869) 20. Isomoto H, Nishi Y, Kanazawa Y, Shikuwa S, Mizuta Y, Inoue K, Kohno S: Immune and Inflammatory Responses in GERD and Lansoprazole.

An analysis of drug-induced liver injury, which showed

In such patients, a liver biopsy is recommended in order to determine the appropriate treatment strategy. In DILI with histology like AIH patients, long-term follow-up is needed to perceive the

Absence of differences in the recurrence rates of hepatitis C

patients who were positive for serum hepatitis B; those with other liver injury causes, such as alcohol, autoimmune hepatitis and primary biliary hepatitis; and those who received a liver transplantation. Following HCC treatment, the patients in the DAA group were treated with one of the following regimens: daclatasvir/

Long-term outcomes of autoimmune pancreatitis

Autoimmune pancreatitis (AIP), which was first proposed as a novel clinical entity by Yoshida et al [1] in 1995, is a unique chronic inflammation of the pancreas [2]

Human Leukocyte Antigen Class II Haplotypes Affect Clinical

and HLA class II DRB1, DQB1, and DPB1 alleles and haplotypes in a larger new cohort of 156 Japanese patients with type 1 AIH and compared them with the published data of 210 healthy subjects. The DRB1*04:05-DQB1*04:01 haplotype was

E˜cacySecukinumab fPPPatient Hysis - Springer

58 CEN Case Reports (2020) 9:55 58 1 3 8. Asahina A, Nakagawa H, Etoh T, Ohtsuki M, Adalimumab MSG. Adalimumab in Japanese patients with moderate to severe chronic

Clinical features in different age groups of patients with

of autoimmune hepatitis (AIH). The aims of this study were to determine the demographic and clinical features of AIH in China. A total of 83 patients with AIH diagnosed by the revised scoring system were re-analyzed, and the clinical presentations among the different ages were compared. The patients were classified according to age at presentation.

Long-term Outcome of Japanese Patients With Type 1 Autoimmune

Long-term Outcome of Japanese Patients With Type 1 Autoimmune Hepatitis Kaname Yoshizawa,1,4 Akihiro Matsumoto,1 Tetsuya Ichijo,1 Takeji Umemura,1 Satoru Joshita,1 Michiharu Komatsu,1 Naoki Tanaka,1 Eiji Tanaka,1 Masao Ota,2 Yoshihiko Katsuyama,3 Kendo Kiyosawa,5 Masanori Abe,6 and Morikazu Onji6 The long-term outcome of patients with