Japanese Type 1 Diabetic Syndrome
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Review Risk Factors Contributing to Type 2 Diabetes and
tes, insulin-dependent diabetes mellitus (type 1 dia-betes mellitus, T1DM) and noninsulin-dependent - diabetes mellitus (type 2 diabetes mellitus, T2DM). T2DM is the most common form of DM, which ac-counts for 90% to 95% of all diabetic patients  and is expected to increase to 439 million by 2030 In .
The Role of Statins in Diabetes Treatment
Adult Japanese (MEGA) trials.18 All of these studies included a substantial portion of subjects with diabetes. A few key primary prevention trials are summarized in Table 1. The HPS provided initial evidence for the routine use of statin therapy in diabetes patients at risk for major CVD events. Patients with nonfast-ing total cholesterol 135
Discontinuation of BCG Vaccination Precedes Significant Drop
Keywords: Type 1 diabetes, type 2 diabetes, BCG, vaccine, cortisol, inflammation. RESEARCH DESIGN AND METHODS BCG vaccine has been linked to an increased risk of type 1 diabetes . BCG immunization was routinely given to Japanese elementary school children age 6 to 7 and junior high school children age 12 to 13 since prior to 1982. Immu-
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Chapter 1 - Type 1 Diabetes Mellitus: An Overview
billion per year.14 However, type 1 DM accounts for only 5e15% of these cases. In the United States, approximately 30,000 new cases of type 1 DM are diagnosed each year; about two-thirds of them are in children under the age of 19 years.12,15 PATHOPHYSIOLOGY The autoimmune trigger in type 1 DM is the result of certain environmental exposures in
eachpredictsthedevelopmentofretinopathy (15).Therelationship between A1C and retinopathy is similar to that of FPG or 2hPG withathresholdataround6.5%(2,16 22
Effects of long-term monotherapy with glimepiride vs
Among 100 Japanese Type 2 diabetic patients, 23 pa-tients (GP/GC group: 11/12) dropped out during the study period.As to the remaining 77 subjects, the base-line characteristics of those in eare shown in ach group Table 1. Before treatment, there were no significant dif-ferences in these parameters between the two groups. As
RESEARCH Open Access Impact of dietary fiber intake on
adjustments for obesity, hypertension or metabolic syndrome did not change these associations. Conclusion: We demonstrated that increased dietary fiber intake was associated with better glycemic control and more favorable cardiovascular disease risk factors including chronic kidney disease in Japanese type 2 diabetic patients.
A new pathological scoring system by the Japanese
Japanese classification to predict renal outcome in diabetic nephropathy Junichi Hoshino1,2*, Kengo Furuichi3, Masayuki Yamanouchi4, Koki Mise5, Akinari Sekine1, Masahiro Kawada1, Keiichi Sumida4, Rikako Hiramatsu4, Eiko Hasegawa1, Noriko Hayami4, Tatsuya Suwabe4, Naoki Sawa4, Shigeko Hara1,
i a b e tes& ournal of iabetes Metabolism
An 18-year old Japanese woman with thirst, weight loss and palpitations for a few weeks duration was admitted. Her diagnosis was diabetic ketoacidosis with acute-onset type 1 diabetes (T1D) and Graves disease (GD) (autoimmune polyglandular syndrome type 3 variant; APS3v). She was treated with intensification therapy with
A 71-year-old man with diabetic ketoacidosis
Jul 25, 2013 Type 1 diabetes Immune mediated Idiopathic Permanent insulinopenia Episodic ketoacidosis with varying degrees of insulin deficiency between episodes Type 2 diabetes Other specific types Genetic defects of β-cell function Genetic defects in insulin action Diseases of the exocrine pancreas Endocrinopathies Infections
Diabetic Ketoacidosis Due to Type 1 Diabetes Mellitus Induced
(AITD) and type 1 diabetes (T1D) . In addition, co-occurrence of T1D and AITD is well known as one of the variants of the autoimmune polyglandular syndrome type 3 (APS 3 variant). We describe the case of a patient with diabetic ketoacidosis (DKA) due to T1D induced by peginterferon α-2b (PEG-IFNα-2b) and ribavirin (RBV) therapy for
Effects of Telmisartan on Insulin Resistance in Japanese Type
telmisartan is exerted clinically in diabetic patients. Methods We compared the effects of telmisartan with those of candesartan, on insulin sensitivity, the serum levels of various adipocytokines and oxidative stress. Patients In total, 85 Japanese type 2 diabetic patients with hypertension, maintained on 8 mg per day of
S Journal of Metabolic Syndrome
Journal of Metabolic Syndrome J Metabolic Synd, an open access journal Volume 5 Issue 4 1000215 ISSN: 2167-0943 Close Association of Hypoadiponectinemia and Increased Insulin Resistance in Non-Obese Japanese Type 2 Diabetes with Visceral Adiposity Hodaka Yamada 1*, Daisuke Suzuki , Masafumi Kakei1, Ikuyo Kusaka1, San-e Ishikawa2 and Kazuo Hara1
Diabetes, the Metabolic Syndrome, and Ischemic Stroke
1.5 3.8]comparedwithnormoglycemia) (34). The Honolulu Heart Program re-ported similar results in nondiabetic pa-tients when comparing the extremes (80thand20thpercentiles)ofserumglu-cose levels (RR for thromboembolic stroke 1.4 [95% CI 1.1 1.8]) (16). A Finnish cohort study measured A1C and fasting glucose in diabetic and nondia-
Painful Neuropathy with Trigeminal Nerve Involvement in Type
syndrome, and is a type of diabetic neuropathy that is usually related to poor glycaemic control. The present case is very unusual in terms of the localization of the acute painful neuropathy as it is usually characterized by severe pain in the thighs 117 S Takayama, M Osawa, Y Takahashi et al. Trigeminal neuralgia in type 2 diabetes
Increased Risk of Acute Pancreatitis in Patients with Type 2
186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P,0.001) compared with non-
Diabetes treatment algorithms Treatment Algorithms, Protocols
control in type 2 diabetic patients. Diabetes Care 2000;23:Suppl 2:B21-B29. 11. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-853. 12.
Concurrent minimal change nephrotic syndrome and type 1
Type 1 diabetes mellitus (T1DM) and idiopathic neph-rotic syndrome are more common in children than in adults. The incidence of T1DM in Japanese children < 14years of age is 1.4 2.25/100,000 , which is much lower than that in other countries, especially Finland (45.0 64.2/100,000 children <15years of age) . Con-
Brief Genetics Report - Home Diabetes
Table 1 shows the frequencies of mutations in type 2 diabetic and nondiabetic control subjects. The I164T mu-tation was found in 7 of 218 diabetic subjects and 2 of 452 nondiabetic subjects. Thus, the frequency of the I164T mutation was signiﬁcantly higher in diabetic (3.2%) than in nondiabetic subjects (0.4%, P 0.007). Furthermore, the
Diagnosis and Treatment of Diabetic Nephropathy in Type 1 and
Diagnosis and Treatment of Diabetic Nephropathy in Type 1 and Type 2 Diabetes Patients Zhenhua He* Washington University in St. Louis, Missouri, USA Introduction Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and the care of patients with diabetes and DN contributes significantly to health care costs.
A rare case of fulminant type 1 diabetes mellitus accompanied
Background: Fulminant type 1 diabetes mellitus (FT1D) is a newly established subtype of type 1 diabetes. Its etiology has not been fully elucidated. Several cases with FT1D have exhibited pancreatitis or myocarditis. Case presentation: We report a 31-year-old Japanese woman who showed upper abdominal pain and was admitted to a local hospital.
Journal of Diabetes Mellitus, 2014, 4, 165-249
Citrate in a Patient with Primary Antiphospholipid Syndrome and Transient Steroid-Induced Diabetes Mellitus: A Case Report and Literature Review F. Grover-Páez, L. García-Benavides, E. G. Cardona-Muñóz, C. G. Ramos-Becerra, J. R. García-Corral,
Autoimmunity as an etiology of fulminant type 1 diabetes
cause fulminant type 1 diabetes in drug-induced hyper-sensitivity syndrome . Moreover, encephalomyocarditis (EMC) virus induced a fulminant type 1 diabetes-like phenotype in a certain mouse strain . These reports suggest the concept that fulminant type 1 diabetes may be caused by viral infection. However, it has been reported
Contents lists available at ScienceDirect Diabetes
The incidence of type 1 and type 2 diabetes in different races based on age. 2 J.B. Classen/Diabetes & Metabolic Syndrome: Clinical Research & Reviews xxx (2008) xxx xxx G Model DSX-92; No of Pages 3 Please cite this article in press as: Classen JB. Evidence childhood epidemics of type 1 and type 2 diabetes are opposite extremes of an
Comparison of health-related quality of life between type 2
in type 2 diabetic patients. Conclusion In type 2 diabetic patients, lower HRQOL was a characteristic feature of subjects with locomotive syndrome, even after adjusting for confounding factors. Prevention or management of locomotive syndrome may be beneﬁcial for improving HRQOL in type 2 diabetic patients.
Recent evidence in the etiology and treatment for diabetic
Oct 01, 2020 in a rat model of type 1 diabetes. Diabetologia 2011; 54: 965 978. 14. Yin W, Jiang Y, Shiqing X, et al. Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon-like peptide-1 on glomeruli and tubules in diabetic rats. J Diabetes Investig 2019; 10: 613 625. 15. Mann JFE, Ørsted DD, Brown-
Safety of ipragliflozin in elderly Japanese patients with
ipragLifLozin treAtment in ELDERly type 2 diabetic patients) was implemented in April 2014 in compliance with the ministerial ordinance on Good Post-Marketing Study Practice (GPSP), and registered all elderly Japanese patients with type 2 diabetes mellitus who were prescribed ipragliflozin within 3 months of its launch.
Type 1 Diabetes Mellitus and Klinefelter Syndrome
obesity and the prevalence of metabolic syndrome (MS) in KS patients is up to 44% (1, 2), which leads to an increased incidence of type 2 diabetes mellitus (T2DM) (1, 2). The concurrence of KS and autoimmune diseases such as type 1 diabetes mellitus (T1DM) is known (3). However, cases of KS and T1DM are rarely reported because the concurrence
Is the Diagnosis of Metabolic Syndrome Useful for Predicting
1,424 Japanese type 2 diabetic patients with and without MetS, as deﬁned by WHO (WHO-MetS) or the NCEP. RESULTS A high prevalence (38 53%, depending on sex and deﬁnition) of MetS was found among diabetic patients, even those with no history of CVD. During the 8-year study period, only WHO-MetS was a predictor for CVD in female patients.
Diabetes Collaborative Registry Data Collection Form
B-type Natiuretic Peptide7120: N-terminal pro b-type Natiuretic Peptide7125: D S D S Insulin Pump6700 Continuous Glucose Monitoring6710 mm / dd / yyyy mm / dd / yyyy →If Yes, Date6702: →If Yes, Date6712: F T 6650 E S / P S Discussion of Lifestyle Modifications Documented6100: O No O Yes
Optimal cut-off point for homeostasis model assessment of
HOMA-IR = 1.7 was determined as the optimal cut-off value, with a sensitivity and speciﬁcity of 73.4% and 70.5% for men, and 81.5% and 77.0% for women, respectively. In conclusion, the optimal c ut-off value for HOMA-IR to disc riminate MetS in non-diabetic Japanese subjects appears to be 1.7.
Ectopic Fat Accumulation in Pancreas and Heart
Mar 23, 2021 of intractable heart disease in diabetic patients (Figure2), and is considered as a new therapeutic target. It has been reported that the thickness of epicardial fat decreased signiﬁ-cantly after administration of canagliﬂozin, an SGTT-2 inhibitor, to Japanese type 2 diabetic patients .
RESEARCH Open Access Prevalence of adrenal masses in Japanese
bolic syndrome [5,6], though there are no reports on the frequency of adrenal masses in type 2 diabetic patients in Japan. Therefore, we investigated the presence of adrenal tumors in Japanese type 2 diabetic patients. Materials and methods Individuals, presenting to outpatient clinics of the Depart-ment of Diabetes, Metabolism and
Literature Review Japanese American: Culture and Care Needs
low physical activity as compared to native Japanese. Second, the prevalence of type II diabetes among Japanese-Americans and death from ischemic heart disease among Japanese-American diabetic patients were higher. Third, the serum fasting insulin level as well as the insulin level after a glucose load,
Components of Metabolic Syndrome and their Combinations as
MetS components among Japanese patients with type 2 diabetes and estimated the risks of CVD presented by these components in this patient group. Methods The Japan Diabetes Complications Study (JDCS) is a nationwide multi-center prospective study of type 2 diabetic patients17). In 1996, 2205 patients aged
The Gut Impacts Diabetic Management Tomorrow: The Recent
of Japanese type 2 diabetic patients than in those of control subjects . Of note, Zhang et al.  further reported significantly lower abundance of Akkermansia muciniphila in type 2 diabetic patients. Although A. muciniphila is a relatively low-abundance bacteria, it has the potential to affect host metabolism profoundly. This
WhatDoTheyHaveinCommon? - Home Diabetes
study of type 1 diabetic patients, who at baseline were 21 years old with diabetes duration of 12 years (22). Prelim-inary data from the FinnDiane Study showed that accord-ing to the National Cholesterol Education Program criteria for metabolic syndrome, one-third of normoalbuminuric type 1 diabetic patients had metabolic syndrome, and 14%
Glucose-lowering effects and safety of DS-8500a, a G protein
119 agonist being developed for the treatment of type 2 diabetes. The study objective was to assess the efficacy and safety of DS-8500a in Japanese patients with type 2 diabetes. Research design and methods In this double-blind, parallel-group, phase II study, 99 Japanese patients with type 2 diabetes were randomized to receive placebo, or