Methylmercury Blood Guidance Values For Canada

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Journal of Trace Elements in Medicine and Biology

Jan 31, 2019 from the National Research Council of Canada, with reference values of 1.40 ± 0.09μg Se/g and 4.47 ± 0.32μg Hg/g (dry weight basis). We observed that Hg recovery was inversely related to the amount of sample digested (p=0.05), F=6.91, Adjusted R2 3

A young woman concerned about mercury

urine and 1000 nmol/L (200 µg/L) in blood.10 For prenatal exposure, prospective cohort studies have suggested that the risk of subtle neurocognitive effects may start at maternal blood mercury levels as low as 200 nmol/L (40 µg/L),9 although guid-ance values are much lower because of the applica-tion of safety factors.


exposure to lead, consumption of milk or alcohol, methylmercury levels from fish consumption, and the potential for mercury from dental amalgam fillings to be transformed into methylmercury within the human body (Kall et al., 2016a; Kall et al., 2016b).


inorganic mercury or methylmercury on the cardiovascular system. Therefore, male Wistar rats were exposed to a broad range of doses of lead, inorganic mercury or methylmercury for four weeks through the drinking water. Cardiovascular health of the rats was assessed by measuring the blood

ICH guideline Q3D (R1) on elemental impurities

guidance, and regulatory authority research and assessment reports. This process follows the principles described in ICH Q3C: Residual Solvents. The available information was reviewed to establish the oral, parenteral and inhalation PDEs. For practical purposes, the PDEs to be applied to the drug product that are presented in

Health Reports - Lead, mercury and cadmium levels in Canadians

above the Health Canada guidance value of 10µg/dL. Similarly, fewer than 1% of Canadian the current Health Canada blood lead guidance value for the general methylmercury. Exposure of the

Testing for Blood Mercury Levels in the General Population

Canada s guidance value. (5) Technology/Technique In clinical laboratories, physicians can test for mercury levels through samples of blood, urine, and hair. Blood tests are generally used to measure the organic form of mercury (methylmercury) because of the high rate of uptake of methylmercury in red blood cells.

CSAF Supplemental Tables Contents -

Methylmercury (JECFA, 2004, 2007) Human Variability (Composite DDEF) Provisional Tolerable Weekly Intake (TWI) from food Human Variability TK = 6.4 (2 x 3.16) Semi-quantitative TK ratio: Maternal hair concentration of 14 μg mercury/g was converted to a blood concentration using the average

Synopsis of Research - University of Calgary in Alberta

[email protected] Development of blood guidance values for persistent organic pollutants for the Canadian Arctic Sources of methylmercury

Cree First Nations of Eeyou Istchee (Quebec, ISSN: (Print

To describe exposure to methylmercury among Cree, focusing on women of childbearing age, we required follow-up according to Health Canada s blood mercury guidance value of 40 nmol/L. 8%

Exposure of Arctic populations to methylmercury from

earliest effects of methylmercury in adults, such as paraesthesia, seem to appear at mater-nal hair concentrations above 50 µg/g, which correspond to blood concentrations above 200 µg/l (7). The foetus is much more susceptible to the toxic effect of methylmercury than the mature adult. Congenital methylmercury poisoning


united nations environment programme dtie chemicals branch guidance for identifying populations at risk from mercury exposure august 2008 issued by unep dtie

Blood and Hair Mercury Levels in Young Children and Women

90th percentile of blood Hg for women and children was 6.2 ppb and 1.4 ppb, respectively (Table 1). Almost all inorganic Hg levels were undetectable; therefore, these measures indicate blood methylmercury levels. The 90th percentile of hair Hg for women and children was 1.4 pprn and 0.4 ppm, respectively.

Occupational Medicine - Choosing Wisely Canada

mercury concentrations above Health Canada s guidance value. As such, the large majority of individuals who present with concerns of metal toxicity do not actually have toxicity, and testing results in false positives (values above the reference range but not in the range of toxicity).

Investigating potential growth, behavioural, and reproductive

Table 2.1 Mean and standard deviation for total blood mercury values, total mercury dose, and an estimate of mean total body mercury for each treatment. Estimated body mercury was obtained by multiplying the bird s blood mercury measurement by its 30 day mass (i.e. mass at time of blood collection). These values are all

COMMENTARY Methylmercury Blood Guidance Values for Canada

Methylmercury Blood Guidance Values for Canada Melissa Legrand, PhD,1 Mark Feeley, MSc,2 Constantine Tikhonov, MD, MHA,3 Deborah Schoen, MPH,4 Angela Li-Muller, PhD5 ABSTRACT Exposure to methylmercury (MeHg) from fish and marine mammal consumption continues to present a public health concern. To date, developmental

Draft -

125 Methylmercury is especially toxic to living organisms, highly bioavailable, and lipophilic, 126 allowing it to pass through membranes, including the blood-brain barrier and the 127 placental barrier (Park & Zheng, 2012). In this way, MeHg can reach vital organs and 128 accumulate in the brain (CCME, 2003; Edmonds et al., 2010; Doe et al

element Department of Emergency Medicine, Pendik Education

Methylmercury blood guidance values for Canada. Can J Public Health 101: 28-31. 6. Nakayama H, Shono M, Hada S (1984) Mercury exanthem. J Am Acad Dermatol 13: 848-852 7. Tintinalli JE, Kelen GD, Stapczynski JS (1999) Emergency Medicine: A Comprehensive Study Guide. McGraw Hill 1191-1193. 8. Goldman LR, Shannon MW, American Academy of Pediatrics:

NIP for AMAP 2013-2015 master

interdepartmental program operated by Natural Resources Canada (NRCan). PERD funds research and development designed to ensure a sustainable energy future for Canada in the best interests of both our economy and our environment. A list of projects funded by PERD 2013-2014, and 2014-2015 is provided in Tables 7a and 7b.


percentile blood concentrations among Atlantic coastal residents (2.7 and 7.7 µg/l) than values measured in Pacific coastal residents (1.7 and 4.7 µg/l) (Mahaffey 2005 cited in Sunderland 2007).14,15 It is estimated that 45% of the methylmercury intake of the U.S. population comes 8 U.S. EPA. 2018.

QUANTITATIVE RESEARCH Blood Total Mercury Concentrations in

Existing Health Canada blood MeHg guidance values were recently expanded to include a harmonized provisional guidance value for children, pregnant women and women of childbearing age (16-49 years).5 The existing guidance value of 20 µg/L is con-sidered to provide adequate protection for females ≥50 years and males >18 years.

Associations Between Omega-3 fatty Acids, Selenium Content

and Northern Development Canada and Health Canada), Health Canada sClimate Change Methylmercury blood guidance values for Canada. Can J Public Health. 101,

Eric Misener Lakehead University, Department of Biology

provides fish consumption guidelines for sport fish in many lakes and Health Canada restricts the commercial sale of fish with levels above 0.5ppm (OMOE 2009). The WHO has suggested that blood methylmercury levels of 200 µg/L or higher would cause neurological effects (WHO 2001). Kosatsky and Foran (1996) suggested that effects

An Analysis of the Relationship between Urinary Mercury

Total Mercury in Blood Health Canada 20 μg /L ( Adult general population) 8 μg /L (Children, pregnant women, and women of childbearing age (16-49 years old)) For the general Canadian population aged 6-79 years. 0.69µg Hg /L The highest levels : males and females aged 40-59 years. 1.04 µg/L (range 0.82 µg/L - 1.32 µg/L)

Longitudinal Mercury Monitoring within the Japanese and

values obtained from all visits to the clinics and data from the open-ended and the 2-week recall survey tools. Hair sampling, fish collection, and Hg analysis. As previously described (Tsuchiya et al. 2008b), multistrand proximal hair seg-ments approximately 6 cm long and 0.5 cm in diameter were cut from the nape of the neck

The Cytotoxic Effects of Methylmercury on Cardiomyocytes: A

Methylmercury (MeHg) is known predominantly as a neurotoxicant, however emerging experimental and epidemiological evidence has shown associations between MeHg exposure and the potential for increased risks of cardiovascular diseases.

Development of Fish Contaminant Goals and Advisory Tissue

the United States and Canada (Petreas et al., 2003; see: Windham et al., 2010). Quiros-Alcala et al. (2011) found that maximum concentrations of BDE -47 and - 99 in house dust collected from low-income California households were the highest reported at that time.

International / National Standards for Heavy Metals in Food

International / National Standards for Heavy Metals in Food Dr YY Choi Chemist Government Laboratory October 2011 1

Guidance for Applying Quantitative Data to Develop Data

(including values) to allow the assessment to proceed when data are limited. This document is consistent with the recommendations in Science and Decisions: Advancing Risk Assessment (NRC, 2009) as it describes the process for developing scientifically supportable values to account for inter- and intraspecies extrapolation.


The biomarker of choice for organic mercury is a blood mercury level N.B. Reference ranges are population averages (NOT levels of toxicity!) E.G.: o. Blood mercury ULN is 18.4nmol/L; toxicity does not occur until 500-1000nmol/L. o. Urine mercury ULN is 3µg/L; toxicity does not occur until 20-100 µg/L. 9

The First Hong Kong Total Diet Study: Metallic Contaminants

cadmium, antimony, methylmercury, nickel, tin were below their respective health-based guidance values for general population For lead, the dietary exposures of average and high consumers were below the level, 1.2 µg/kg bw/day, considered by JECFA to have a low risk of increasing the systolic blood pressure in adults

Syracuse University SURFACE

than twice the values observed in the remainder of the state (382 ng/g vs. 162 ng/g respectively; Simonin, Loukmas, Skinner, & Roy, 2008). In Northern Europe, the northeastern United States, and southeastern Canada, aquatic ecosystems are showing signs of recovery from acid deposition (Driscoll et al. 2001, Jeffries et al. 2003).

The First Hong Kong Total Diet Study: Metallic Contaminants

tin were below their respective health-based guidance values. 5. For lead, health-based guidance values are not available. The estimated exposures to lead for average and high consumers were 0.21 and 0.38 µg/kg bw/day, respectively which were below the level of 1.2 µg/kg bw/day considered by the Joint Food and Agriculture Organization / World

Dietary Exposure Assessment and Contaminants Biomonitoring in

Canada s recommended guidance value of 6 mg/kg. Mean hair mercury was 0.74 mg/kg, with a geometric mean of 0.38 mg/kg. Generally, only a small proportion of trial values exceeded Dietary Reference Intakes for fatty acid subgroups DHA, EPA+DHA, and total omega-3 PUFAs.

Biomonitoring of Mercury in Hair among a Group of Eritreans

Mar 15, 2020 human and environmental health [23 28]. Hg concentrations in blood and hair have been used as biomarkers to assess the human exposition to this element [29]. The total Hg in human hair is a good indicator of long-term Hg exposure, particularly for methylmercury [30]. The hair-to-whole blood ratio has been estimated to be about 250 to 1 [30,31].

Peer review of draft proposed rule for Mercury Water Quality

To compare methylmercury concentrations in fish tissue to the FTC, fish mercury samples are collected within a calendar year and subsequently combined into one value. The rationale for summarizing values over a longer period of time is that potential adverse consequences of methylmercury exposure are

Use of Biomonitoring

Scientific Guidance Panel elevated total blood mercury reflects methylmercury exposure Canada (n=2678) Germany (n=709) * Blood mercury values are for adult

was not reported, isolation measures ideally should have

estimates of methylmercury exposure in the general population were based on exposure models using fish tissue Hg concentrations and dietary recall survey data (1). The NRC review provided guidance to the Environmental Protection Agency (EPA) for developing an exposure reference dose for methylmercury (i.e., an estimated daily exposure that

Relationship between Mercury Concentrations in Hair and Blood

1.3 Two matrices to track mercury exposures: hair and blood 7 1.3.1 Pros and cons of blood 8 1.3.2 Pros and cons of hair 9 1.3.3 The comparison of blood and hair as biological matrices 10 1.4 The relationship between Hg concentrations in hair and blood 13 2. Study rationale 17 3. Objectives and Hypotheses 19 4. Methods 20