Orbital Lymphoma Symptoms
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PRIMARY NON-HODGKIN LYMPHOMA OF THE ORBIT PRESENTING WITH
Orbital lymphoma can arise from the eyelid, orbit, lacrimal glands or conjunctiva. Clinical signs and symptoms are nonspecific, often delaying the diagnosis. In 25% of the cases the conjunctiva is involved and the patients present with salmon red patches or swollen conjunctiva. In the rest of the patients, presentation is with orbital mass [2
Rhea V. Morgan, DVM, DACVIM (Small Animal), DACVO
Most orbital tumors in dogs and cats are malignant. Examples of primary cancers include the osteosarcoma (from bone), fibrosarcoma, chondrosarcoma (from cartilage), meningioma of the optic nerve, rhabdomyosarcoma (from muscle), mast cell tumor, neurofibrosarcoma (from nerves), and hemangiosarcoma (from blood vessels). Lymphoma can also
Ocular, Orbital and Periorbital Neoplastic Conditions of the
(lacrimal gland adenocarcinoma) or lymphatic tissue (lymphoma or lymphosarcoma), extra-adrenal paraganglioma (Miesner et al., 2009), hemangiosarcoma, melanoma and orbital extension of tumours from the eye, eyelids or conjunctiva (usually either carcinoma or lymphoma) and extensions
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Radiosugery with CyberKnife in Primary Orbital MALT Lymphoma
Lymphoma. J Natl Cancer Inst 96 (2004): 586-594. 10. Dandan Zhang, Lina Dong, Haiyan Li and Hasi Jin, et al. Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma in Northern China: High Frequency of Numerical Chromosomal Changes and No Evidence of an Association with Chlamydia Psittaci. Leuk Lymphoma 51 (2010): 2031-2038. 11.
Orbital Metastasis as Primary Presentation of Misdiagnosed
at the time of presentation. Other presenting signs or symptoms include ptosis, eye lid swelling and diplopia. Often, the possibility of an inflammatory process is raised. An excision biopsy often confirms the seemingly improbable diagnosis of an orbital metastasis. Orbital metastases remain an unfavorable prognostic
Ptosis as an Initial Manifestation of Orbital Lymphoma: A
for orbital lymphoma at that point was not too late. The patient had a complete remission of the tumor after chemotherapy. On CT scan, orbital lymphoma usually appears as a homogeneous molding mass with sharp margins, most often localized in the anterior portion of the orbit, the retrobulbar area, or the superior orbital compartment [9,10].
Mantle Cell Lymphoma in the Orbital and Adnexal Region
May 07, 2009 Patients with orbital and adnexal region MCL as first presenting symptom comprised cases with primary MCL and cases with orbital and adnexal lymphoma with non-diagnosed preexiting extraorbital disease. Clinical data Clinical data recorded for each patient included year of diagnosis, gender, age, symptoms and
Partial orbit irradiation achieves excellent outcomes for
niquesfor treating lymphoma involvingthe conjunctiva,15 and other orbital sites.7,16,17 Partial orbital treatment of conjunctival lesions was performed using a clinical setup. An anterior electron field was used in conjunction with a small diameter lens shield placed anterior to the lens. Rather than lower energy
Case Report Orbital Lymphoma Masquerading as Orbital Cellulitis
Lymphoma of orbit can masquerade as orbital cellulitis [14 17]. The pathophysiology behind orbital lymphoma presenting as orbital cellulitis can be due to direct tumor invasion responsible for inﬂammation of orbital soft tissues . Orbital cellulitis is an infectious condition of the orbital soft tissues posterior to the orbital septum.
Orbital lymphoma: imaging features and differential diagnosis
orbital lymphoma. The characteristic distribution and in-filtration of some orbital structures will define useful items to orientate a proper diagnosis. Additionally, this information can be helpful in ophthalmological surgery to obtain an optimal sample for accurate diagnosis. Dif-ferential diagnosis regarding the location of orbital masses
Review Article Orbital lymphoma: Role of radiation
Orbital lymphoma refers to a lymphoma occurring in the conjunctiva, lacrimal gland, eyelid and ocular musculature. Primary non-Hodgkin™s lymphoma (NHL) of the orbit is a rare
Treatment volume definition for irradiation of primary
Although orbital lymphomas comprise a small proportion of of all lymphomas, primary lymphoma of the orbit occurring in the conjunctiva, lacrimal gland, eyelid and ocular musculature is a frequent orbital tumor accounting for approximately one half of all orbital malignancies . Histology may mostly consist
Treatment of Benign Lymphoid Hyperplasia of the Orbit With
lymphoma and rheumatoid artltitis. We report successful treat-ment of 2 patients with bellign lymphoid hlperplasia of the orbit with rituximab. CASE REPORTS Case 1. A 4l-year-old wonan wirh a history ofbenign lymphoid hyperplasia ofthe right orbit was evaluated by our orbital oncol-ogy service after the onset ofperiorbital swelling. ptosis
Orbital Lymphoma-An International Multicenter Retrospective Study
TABLE 1. Eye Cancer Center Distribution of Patients by Subtype of Orbital Lymphoma Eye Cancer Center CPH LIV HOU HYD NY ATL MEL Subtype, N (%) 256 (32) 94 (12) 188 (24) 159 (20) 29 (4) 14 (2) 57 (7)
leptomeninges Systemic non-Hodgkin s lymphoma involving the
Lymphoma is the most common orbital malignancy, has a predilection for the elderly, and classically presents as painless prop-tosis or adenexal swelling over a duration of 5 7 months.7,9 Non-Hodgkin s lymphoma is reported11 to have an orbital presentation in 2.4% of all non-Hodg-kin s lymphoma cases, while its prevalence is about 5%
ARROCase Orbital MALT
Orbital/Ocular Adnexal Lymphoma Lymphomas are the most frequent tumor of the ocular adnexa. Ocular Lymphomas: 1) Marginal Zone Lymphoma of MALT (~40-80%) 2) Follicular Lymphoma (~20%) 3) Diffuse Large B-Cell Lymphoma (~8%) 4) Mantle cell, small lymphocytic, lymphoplasmacytic (these are less common)
Lessons of the month 2: Ocular manifestations and
zone B-cell lymphoma. This case illustrates the importance of considering the various ocular manifestations of hepatitis C. KEYWORDS: ocular lymphoma, hepatitis C, orbital inflammatory syndrome DOI: 10.7861/clinmed.2021-0320 Case presentation We present a case of a 47-year-old man who was admitted for
CASE REPORT Open Access Lymphoma of the orbit masquerading as
Orbital lymphomas are relatively rare, comprising only 1% of all non-Hodgkin s lymphoma . However, orbital lymphomas are the most common primary orbital tumor in adults 60 years of age and older . Margo and Mulla reported a 55% rate of lymphomas involving the orbit amongst 300 patients with orbital malignancies .
Primary Ocular Lymphoma: Clinical Features, Diagnosis, and
Orbital lymphoma is localized to the structures surrounding the eye such as the eye-lid, orbital soft tissues, or lacrimal gland and presents with diplopia, ptosis, or proptosis; it does not involve the globe itself. Primary ocular lymphoma is a lymphoma of the vitreous or reti-na and spares the orbital cavity; it usually presents with floaters
MR Imaging of Orbital Inflammatory Syndrome, Orbital
Orbital Cellulitis, and Orbital Lymphoid Lesions: The Role of Diffusion-Weighted Imaging R. Kapur A.R. Sepahdari M.F. Mafee A.M. Putterman V. Aakalu L.J.A. Wendel P. Setabutr BACKGROUND AND PURPOSE: Orbital inflammatory syndrome (OIS) has clinical features that overlap with orbital lymphoid lesions and orbital cellulitis.
Orbital lymphomas missed by first biopsies of orbital masses
Orbital lymphoma can mimic inﬂammatory orbital disease and other diseases in clinical presentation and imaging (Polito et al. 1996; Gordon 2006; Igarashi et al. 2013; Hwang et al. 2014). In present report, a secondary biopsy was necessary in each case because of either recurring symptoms during treatment, or clinical presenta-
Orbital T-cell lymphoma in youngest recorded patient early
Orbital and ocular adnexal lymphoid neoplasms are not scarce, representing 6 to 8% of all orbital tumors, whereas out of the extranodal non-Hodgkin s lymph-omas, primary non-Hodgkin s lymphoma of the orbit represented 8 to 10% [8, 9]. Based on case series, the most reported orbital lymphoid tumor was B cell non Hodgkin malignant lymphoma
Signs and Symptoms of Childhood Cancer: A Guide for Early
Aug 01, 2013 with leukemia or lymphoma.11 Symptoms such as pallor, fatigue, malaise, and reduced level of activity that are not (orbital location), vaginal bleeding (vaginal location) Renal tumors (mainly
Prevalence and Nature of Systemic Involvement and Stage at
The symptoms at diagnosis of orbital and ocular ad-nexal lymphoma included a palpable mass in the orbit oreyelidin14patients(33%),eyelidorperiorbitalswell-ing in 12 patients (28%), proptosis in 9 patients (21%), diplopiain8patients(19%),uppereyelidptosisin4pa-tients (9%), excessive tearing in 4 patients (9%), fever,
Extranodal natural killer T-cell lymphoma, nasal type
presents with non-specific symptoms in the early stages of the disease. Overall prognosis is dismal, with a five-year survival rate of 30%, with some sources citing a survival rate of 13% beyond 13 months for patients with orbital involvement [1 4]. Those occurring outside of the nasal cavity are highly aggressive and carry a poorer prognosis.
Orbital inflammatory disease management
Orbital inflammatory disease (OID) represents an etiologically diverse spectrum of conditions unified in their association with abnormal inflammation in the periorbital region. These condi-tions can be roughly grouped into two categories, specific orbital inflammatory disease (SOIS) and nonspecific orbital inflammatory disease (NSOIS).
Orbital Lymphoma: Results of Radiation Therapy
Orbital lymphoma is a rare presentation of non-Hodgkin s lymphoma. Treatment with radiotherapy is well-established. Twenty cases of orbital lymphoma treated at the Singapore General Hospital with radiation therapy were reviewed. All patients had impr ovement of their initial presenting symptoms and complete remission after radiation.
Late presentation of orbital lymphoma: The good, the bad and
of orbital EMZL with systemic involvement that had an ugly, disfiguring presentation with bad ocular signs and symptoms that eventually has a good outcome with appropriate treatment. KEY WORDS: Lymphoma, orbital tumour, extra-nodal marginal b cell lymphoma, ocular displacement 29 Late repair of descemet membrane detachment following
Orbital Neoplasms in Adults: Clinical, Radiologic, and
adult orbital tumor. They typically appear as a well-circumscribed, ovoid intraconal mass on cross-sectional images. Lymphoma, which may be pri-mary or secondary to systemic disease, is the most prevalent orbital neo-plasm in older adults (≥60 years of age). Choroidal melanoma is the most common primary adult ocular malignancy.
Diagnosis and Management of Orbital Lymphoma
While lymphoma constitutes more than half of all orbital malignancies (55 percent),1 the incidence of orbital lymphoma has been reported to ac-count for between 1 and 10 percent of NHL cases.2 Orbital lymphoma may be unilat-eral or bilateral. Although it has been known to present in patients between 15 and 70 years of age, most cases
Orbital Lesions: Differentiating Vascular and Nonvascular
proptosis, orbital pain, and diplo pia. In most cases, the effect is caused by softtissue lesions. However, vascular lesions, either within the orbits or extraorbital, can alter the normal orbital blood flow pattern and lead to vascular engorgement and an orbital mass effect [1, 2]. More confusingly, soft tissue
Plasmablastic lymphoma mimicking orbital cellulitis
Introduction Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and ade-quately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of cases have been reported in which these symptoms have been
Orbital lymphoma in an elderly patient
Orbital lymphomas are rare, comprising only 1% of all non-Hodgkin s lymphoma.1 Lymphomas are the most common primary orbital tumor in adults of age 60 years and older.2 Three hundred fourteen primary orbital malignancies were reported by Margo and Mulla, 55% of which were orbital lymphoma.3 CASE REPORT
Case Report: Atypical Lymphoid Infiltrate of the Right Orbit
Orbital lymphoid tumors are rare and present with nonspecific signs and symptoms. Awareness of presenting symptoms may aid in early intervention. The following case demonstrates the diagnosis, management, and treatment of orbital lymphoid infiltrates. I. Case History 34 year old Hispanic male
A Case of Pixelated Vision - aao.org
strated an orbital process likely contrib-uting to his symptoms, which improved with steroids, we still did not have a diagnosis. The differential diagnosis included immunoglobulin (Ig)G4 related disease, reactive lymphoid hy-perplasia (RLH), and lymphoma.1 Diagnosis and Treatment Mr. Beauchamps was then scheduled
Diffuse large B-cell lymphoma masquerading as orbital cellulitis
Orbital lymphoma and lymphoma of the orbital adnexae are relatively rare lymphomas, representing 0.1% of all lymphomas.1 Lymphomas of B-cell lineage are more likely to be associated with symptoms related to the eyes and to have extension to the orbit than are lymphomas of T- or NK-cell lineage.2 The most common clinical signs of orbital lymphoma
Orbital lymphoma: diagnostic approach and treatment outcome
B-cell lymphoma and mantle cell lymphoma received systemic chemotherapy according to the R-CHOP protocol. Conclusions: Owing to unspecific clinical symptoms, some diagnostic delay may occur in orbital lymphoma. If unspecific orbital symptoms are present, adequate imaging studies followed by early surgical biopsy will contribute to early diagnosis.
CO Diagnosis of enlarged extraocular muscles: when and how to
Paraneoplastic orbital myopathyb MR or SR All muscles, bilateral (lymphoma) Lacrimal gland swelling (thyroid carcinoma) Orbital cellulitis Any muscle aAny muscles Adjacent sinus, orbital, or lacrimal gland infection Neoplastic Lymphoma Any muscle Any combination of IR, MR, LR, SR, LPS occasionally bilateral Lacrimal gland swelling; mass
Mantle Cell Lymphoma Relapsing as Disease of Skin, Orbit and
plopia and a rash of the left breast. Skin biopsy showed lymphoma infiltrates with B-cell markers for MCL. MRI of the orbits and brain suggested orbital lymphoma. CSF cytology further confirmed MCL cells. At time of relapse, she continued to be in hematologic remis-sion. She initiated intrathecal cytarabine and methotrexate along with ibrutinib.