Structure‐function Analyses Of The Kit Receptor For The Steel Factor

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c-kit and its related genes in spermatogonial differentiation

of the Kit.30,31 Tr-Kit derived from alternative promoter in the intron 16 of c-kit and encodes part of the non-conserved insert from the C-terminal tail region and the distal phosphotransfer - ase kinase region, and it lacks the entire extracellular and the transmembrane domain.32 This intronic promoter of the c-kit

Optimisation of the Degree of Sulfation of a Polymer Based

gp120, this analysis of gp120-polyanion interactions has been limited to monomeric gp120 derived from T-cell line adapted isolates of HIV-1 that used CXCR4 as their chemokine co-receptor (Moulard et al., 2000). Primary viral isolate derived soluble gp120 has not been studied because it has not been available. Recent crystallographic,


-leukemia inhibitory factor -monoclonal antibody -mast cell growth factor (=SCF=c-kit ligand=steel factor) -messenger RNA -mouse spleen conditioned medium -nucleotide -operational taxonomic unit -polyacrylamide gel electrophoresis -phosphate buffered saline -peripheral blood lymphocyte -polyethylene glycol -phytohaemagglutinin

Muta-genetics or muta-genomics: the feasibility of large

betes (leptin receptor), gld (Fas ligand) and lpr (Fas receptor), and steel (Kit ligand) and white (Kit receptor) are notable examples (Bedell et al. 1997a, 1997b). Issues concerning detection and numbers seriously limit the general utility of spontaneous mutations. Many of the important classical mutants have an obvious phenotype such as coat

Transcriptional regulation: Kamikaze activators Dominique

factor by Wu et al. [7] lends further support to the idea that potent activation domains can simultaneously serve as signals for proteolysis. Mi is an essential effector of the c-Kit receptor tyrosine kinase during melanocyte develop-ment. Activation of c-Kit by its ligand Steel results in phosphorylation of Mi by two downstream kinases in the

Perspectives Series: Molecular Medicine in Genetically

tory factor (10, 22, 23). Numerous hematopoietic cytokines are Address correspondence to Stuart H. Orkin, Howard Hughes Medi-cal Institute, Research Laboratories, The Children s Hospital, 300 Longwood Avenue, Boston, MA 02115. Phone: 617-355-7910; FAX: 617-355-7262. Received for publication 4 August 1995 and accepted in revised form 1

Structureâ function analyses of the kit receptor for the

Structure-Function Analyses of the Kit Receptor for the Steel Factor Janna M. Blechman, Sima Lev, David Givol, Yosef Yarden Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel Key Words. Growth factor Tyrosine kinase Signal transduction Oncogene Ligand binding site Receptor dimerization Abstract.