Delayed Presentation Of Primary Testicular Seminoma
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Diagnosis and Treatment of Early Stage Testicular Cancer: AUA
of testicular atrophy, cryptorchidism, or younger age at presentation.8 Routine testicular self-examination is recommended. If GCNIS is present on biopsy, the risk of GCT is 50% over the subse-quent 5 years.9 Management options for GCNIS include surveillance, radiation, or orchiectomy. Chemotherapy is not recommended.
Diagnosis, staging, and natural history of testicular tumors
OF TESTICULAR TUMORS ANTHONY A. BORSKI, MD, FAGS Testis tumors are uncommon and most occur between the ages of 20 to 35 years. With rare exception they are malignant. Probably 35% of patients have metastasis when they are first seen. The most common finding is a painless enlargement of the testis.
Adult Patients Presenting with Undescended Testis in
delayed their seeking medical attention. Two (11.1%) cases were diagnosed by their spous-es while one (5.6%) was incidentally discov-ered during examination by a health worker. The clinical features of the study group are shown in the Table. Of the 8 men with unilateral undescended testes, the contralat-eral testicular volume was normal in two
Penile Metastasis as Unusual Presentation of Testicular Non
with a variable interval from the diagnosis of testicular tumor (from 2,5 to 24 month). Clinical presentation represents one of the main points in our case, because about 4 months needed to discover the primary tumor in the testis. Both synchronous and asymptomatic presentations certainly contributed to delayed diagnosis. Metastatic mechanism
Adult Extragonadal Germ Cell Tumors
cell tumors account for 15% of primary ante-rior mediastinal tumors . More than half of mediastinal germ cell tumors are mature teratomas. Among malignant mediastinal germ cell tumors, 40% are seminomas and 60% are nonseminomatous tumors. Seminoma The peak incidence of seminoma is seen in the third and fourth decade of life. Sem-
PMH CLINICAL PRACTICE GUIDELINES TEMPLATE
of testicular cancers or improves mortality. 4. DIAGNOSIS Diagnosis of testicular cancer is usually made with a scrotal ultrasound followed by radical inguinal orchiectomy. Occasionally, in case of urgent need to start treatment, orchiectomy may be delayed until after treatment of metastatic disease has been completed.
Use of Tumor Markers in Testicular, Prostate, Colorectal
Tumor Markers in Testicular Cancers Ulf-Håkan Stenman, Rolf Lamerz, and Leendert H. Looijenga delayed until after chemotherapy in individuals with life-threatening metastatic disease. After orchiectomy, additional therapy depends on the type and stage of the disease. Surveillance is increasingly used for seminoma patients with stage I disease,
Synchronous Advanced Pure Seminoma and Diffuse Large B-Cell
primary extragonadal germ cell tumors, in this case, this is unlikely because of the patient s history of testicular cancer risk factors: bilat-eral undescended testicles and abnormal sonographic appearance of the right testicle. Therefore, we feel as though this case represents an advanced seminoma likely originating from the right testicle. The
Cancer News October 2014 - Cancer Institute & Research Center
that second primary germ cell tumors resp ond well to treatment are other factors which indicate that one should not get carried away by this entity. Seminoma Management of Low Stage Testicular Seminoma: Early- stage seminoma, represents stage I and IIa (minimal retroperitoneal spread). Testicular seminoma represents
Alexander K Chow , Jerome Hoeksema and Dian Wang
7years out after treatment and remission of the primary extragonadal germ cell tumor. Several case reports have shown that the median time of delayed presentation of MTT can range between 14 and 102months with an aver - age of 60months after treatment of EGCT. 1,3 8 There is often histological disagreement between EGCT and MTT
Chance diagnosis of mixed gonadal dysgenesis in an adult case
abnormality and primary amenorrhea. Indeed, diagnosis was delayed until the patient was 25 years old and was only discovered by chance during treatment for a malig-nant gonadal germ cell tumor. MGD is a disease that may be diagnosed based on short stature, abnormal external genitalia, or primary amenor-rhea.
Testicular Cancer: Diagnosis and Treatment
Testicular cancer is the most common solid tumor among males 15 to 34 years of age, with an estimated 8,850 new cases and 410 deaths during 2017 in the United States. With effective treatment, the
Spermatocytic Seminoma: A Case Report - SCIAEON
Spermatocytic seminoma (SS) is a rare tumor, representing less than 2% of testicular cancers, unlike these tumors, it is never associated with intratubular germ neoplasia or other types of germ cell tumors. Occurring frequently in the elderly men. Spermatocytic seminoma must be
Benign testicular cavernous hemangioma presenting with acute
testicular enlargement and pain, which may be due to intra-testicular bleeding caused by blunt testicular injury. The differential diagnosis must include germ cell tumors (e.g., seminoma and teratoma), adenomatoid tumor and sex - cord stromal tumors, such as Sertoli cell tumor. Sonography is the primary modality used for imaging scrotal lesions.
Tandem Transplant for Germ Cell Tumors History of IU BMSCT
Primary age group is 15-35 for non-seminomatous germ cell tumor (NSGCT) and a decade older for seminoma For 2011 estimated new cases 8,290, deaths 350 (American Cancer Society.: Cancer Facts and Figure s 2011. Atlanta, GA: American Cancer Society, 2011) Risk Factors Cryptorchidism (undescended testis) A family history of testis
Sonographic detection of occult testicular neoplasms
.In4%-14% ofpatients, theinitial clinical presentation issecondary tometastatic disease .Careful examination ofthescrotum often demonstrates aneasily palpable tumor inmost patients. However, inasmall number ofpatients withmetastatic testicular tumors, thetestis isnormal to palpation. Although cases ofextragonadal primary germinal
Research Article Testicular Germ Cell Tumors in Men with Down
than the general population [6-9]. The presentation of testicular cancer is similar to that of nondisabled persons: painless nodule and a swelling of the scrotum. Due to intellectual disability, indivuduals with DS may not adequately convey their symptoms and pain, often leading to delayed diagnosis and potentially worse outcome .
ESMO Preceptorship on Adolescents and Young Adults with
Clinical Presentation Usually a painless, gradually enlarging testicular mass Pain in 10-20% of cases (can be misdiagnosed as orcheo-epididymitis) Gynecomasty (β-hCG secreting tumors) Symptoms due to metastasis (back-pain, Fatigue, cough, dyspnoea ) Unusual presentations
Role of primary chemotherapy in management of large tumors of
treatment of primary tumor may differ, especially when patients present with a large abdominal mass. Induction chemotherapy followed by delayed excision of the primary, and excision of residual metastatic nodes appear to be a logical approach to large and bulky tumors in UDT with or without retroperitoneal disease. AIM
Kapil Dev, Jaiprakash Gurawalia, Shiva Kumar, Chunduri
health care facilities leads to delayed presentation of the patient. However, awareness regarding undescended testis and its related complications must be increased at various levels by the parents, school medical officer and the patient himself. References 1. Alshyarba MH. A giant intra-abdominal testicular seminoma. Biomed Res. 2010;21(3):227
102 Case Report Granulomatous reaction of primary mediastinal
seminoma is the second most common tumor type after mature teratoma, accounting for approximately 37% of all mediastinal GCTs and 25% of extragonadal GCTs (2,3). The diagnosis must be considered after exclusion of primary testicular tumor and can be made with percutaneous needle biopsy alone, unless the tumor is masked by secondary
The role of tumour markers in the diagnosis and treatment of
survival rates for seminoma and teratoma are 97.5% surgery in the management of gestational tumours. This and 89%, respectively . These remarkably good sur- review discusses the current and potential future roles vival values are to a large extent the result of new of established and novel serum markers for testicular
Retroperitoneal seminoma, a rare cause of testicular pain
and delayed diagnosis. There should be a lower threshold for investigating patients with persistent testicular pain in the presence of a normal testicular examination, due to referred pain from retroperito - neal tumours to the testis. CaSe preSenTaTion A 46-year-old man was admitted to the local acci-dent and emergency department, complaining of a
treatMeNt of relapsed disease - sign.ac.uk
for patients with stage iiC and iid seminoma, chemotherapy is the recommended initial treatment. C priMarY MaNaGeMeNt Preoperative investigation preoperative investigations should include assay of afp, HCG, and ldH, bilateral testicular ultrasound, and a chest X-ray. d Patients with metastases where the diagnosis is not in doubt,
Canadian consensus guidelines for the management of
Clinical presentation of germ cell tumour Most patients present with a primary tumour in the testis. Delay in diagnosing germ cell cancer, which has been shown to affect outcome, may be caused either by patients who ignore symptoms for too long or by physicians who fail to make the correct diagnosis. 8 In a minority of patients, the
Tumor-like Presentation of Primary Angiitis of the Central
Primary angiitis of the central nervous (PACNS) is an uncommon entity; tumor-like presentation is a rare manifestation of these diseases and must be considered in the differential diagnosis of cerebral space occupying lesions (CSOL). We add two cases to the literature. Methods: Case reports of two patients with tumor-like presentation of PACNS.
Advances in the treatment of testicular cancer
Seminoma Seminoma represents approximately 60% of testicular GCTs. The incidence of testis tumors has risen over the last decade mostly due to seminomas (16). At presentation 80% of cases are stage I. Seminoma cases have a comparatively better prognosis than non-seminoma and stage III are very uncommon. Clinical research in GCT and seminoma in
teratoma to lung
well these primary tumours were sampled. The numberofsections fromthe testicular tumoursvar-ied between 2 and 12. Details ofpatient treatment are to bepublished elsewhere. Results The primary testicular tumours were classified as malignant teratoma undifferentiated (n = 11), malignantteratomaintermediate (n = 7), ormalig-nant teratoma
Atypical Presentation of Seminoma in the Prostate Case Report
potential.4 They are different from primary GCTs with respect to distribution of histological subtypes, delayed presentation of EGCT, and nonseminomatous tumors are often associated with Klinefelter syndrome and hemato-logical malignancies.5 In the absence of primary testicular involvement, seminoma originating from the prostate is extremely rare.
Histopathological and Clinical Characteristics of Testicular
The age at presentation and the histopathological type of testicular germ cell among Jordanian patients are similar to those currently published in the world records. However, the diagnosis is delayed; this implies that the concerned stakeholders should emphasize the need of patient education and physician awareness.
Urology Prostate cancer - 1 File Download
Seminoma the most common 2. Non-seminoma Usually present at earlier age (30-34 years old) Risk factors Cryptorchidism (undescended testis), increases the risk 10 times higher Orchidopexy at age 6 months Features Painless lump in the body of the testis the most common presentation Diagnosis
A giant testicular mixed germ cell tumour
reasons why this patient delayed presentation. Efforts should therefore be made to increase public awareness and pro-mote health education among adolescents regarding the signs and symptoms of testicular tumours, and the impor-tance of testicular self-examination. References 1. Kin T, Kitsukawa S, Shishido T et al.
TESTICULAR TUMORS: WHAT S NEW, TRUE, IMPORTANT
Seminoma Most common type of testicular GCT (up to 50%) Average age = 40.5 years (decade later than others GCT) Usually presents with testicular mass Pain or dull aching sensation A few present with metastatic disease-75% limited to testis-20% retroperitoneal involvement-5% distant metastases-may have mild elevated HCG, AFP
case RepoRt opeN access Primary malignant lymphoma of testis
Introduction: Primary testicular lymphoma or delayed diagnosis are there due to same age group of presentation as that of germ cell tumors.
Supraclavicular left neck mass: an unusual presentation of
Investigations revealed metastatic primary testicular seminoma. CT contrast study of the thorax, abdomen and pelvis demonstrated an additional left para-aortic nodal mass in both cases. The initial presentation of a solitary left neck lump from a metastatic testicular seminoma is extremely unusual, especially in an older age group. The
Testicular germ-cell tumours and penile squamous cell
Testicular tumours basically affect young men between 20 and 40 year-old, at the beginning or in full employment, social and af-fective life [1e5]. The annual incidence of testicular and para-testicular tumours is 3.29 (95% CI 3.27e3.32) cases per 105 individuals, corresponding to 16,061 newcases in 2013 in EU28 .
Hallmarks of Cancer explored in testicular germ cell tumors
Seminoma/ dysgerminoma/ germinoma reprogrammed to non-seminoma/ non-dysgerminoma/ non-germinoma Naïve-state (totipotent) PGC/gonocyte undergoing global demethylation Erased Aneuploid (+/- triploid) gain: X,7,8,12p,21 loss: Y,1p,11,13,18 in mediastinum and midline brain also (near)diploid and (near)tetraploid with gain of 12p Not available III
Progress in the management ofsolid tumours
Testicular carcinoma AnnO'Callaghan, GrahamMMead Summary Testicular canceris the common-est malignancy in young males and its incidence has more than doubled in the last 25 years. For clinical purposes, two tumour types are identified, seminoma and non-seminoma germ cell tu-mours (loosely known as terato-mas). Stage I disease is confined to the
Nonseminomatous germ cell tumor of the testis 9 years after a
the high cure rate for testicular seminoma. Testicular biopsy at the time of original diagnosis, although recommended by other authors,10 does not appear to be warranted. We do not recommend routine testicular biopsy in these patients because treatment of CIS remains controversial, delayed testicular malignancy