Immunological Alterations In Psoriasis

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Update on psoriasis immunopathogenesis and targeted immunotherapy

Psoriasis is a phenotypically heterogeneous, immune- stantiated by immunological data [6]. interplay between external factors and genetic alterations that

Somatostatin, dendritic cells and peptide T in psoriasis

selectin (Groves et al 1991). The immunological events in psoriasis closely resemble a T-helper 1 type immune response, primarily accompanied by production of IL-2 and IFN-N (Barker et al 1991). ICAM-1 (intercellular adhesion molecule 1) is expressed on keratinocytes in psoriasis lesions, unlike in normal skin (Lisby et al 1989).

Critical role of environmental factors in the pathogenesis of

Psoriasis is a common cutaneous disease with multifactorial etiology including genetic and non-genetic factors, immunological disorders Many alterations

Dysregulated epigenetic modifications in psoriasis

Psoriasis is a chronic inflammatory autoimmune skin disorder that Histological and immunological analyses have revealed that similar to genetic alterations,

PUVA Bath Therapy Strongly Suppresses Immunological and Epide

Psoriasis is characterized by alterations in both the epidermis and dermis of the skin. Epidermal keratinocytes display marked proliferative activation and differentiate along an alternate or regenerative pathway, while the dermis becomes infiltrated with leukocytes, particularly interleukin

The role of epigenetics and immunological imbalance in the

Psoriasis (Ps) is a chronic, inflammatory predomi-nantly skin-tropic disease that affects up to 3% of the general population with a geographical gradi-ent.1 3 The most common form is plaques Ps or psoriasis vulgaris, which is characterized by red, well-demarcated plaques and silvery dry scale located predominantly on elbows, knees, and scalp,