Some Observations On The Electrical Termination Of Arrhythmias

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T-Wave Alternans and the Susceptibility to Ventricular

T-wave fluctuations secondary to electrical alternans to-talis (alternans of all ECG components, such as in pericardial effusion) or QRS alternans. Visible TWA was first reported in the early 1900s during tachycardia and ischemia in remarkable observations by Hering (18) and Sir Thomas Lewis (19). Subsequently, visible TWA of

Characteristics of intracellular Ca2+ cycling in intact rat

acquired long QT syndrome-based arrhythmias and bradycar-dia-induced torsades de pointes, whereas men are more likely to develop atrial fibrillation, early repolarization, and Brugada syndromes and sudden cardiac death (9). It has been suggested that one of the reasons underlying this difference is the com-

Entrainment and termination of reentrant wave propagation in

observations concerning periodic stimulation of a class of cardiac arrhythmias caused by reentrant wave propagation in the human heart. @S1063-651X~96!08606-0# PACS number~s!: 87.22.2q, 03.40.Kf, 87.10.1e I. INTRODUCTION Cardiac tachycardias are abnormal cardiac rhythms in which the heartbeat is too rapid @1,2#. It is believed that some


patients, experimental and clinical observations allow us to infer the mechanism underlying many ventricular arrhythmia syn-dromes encountered in practice. ventricular tachycardia due to reentry Reentrant arrhythmias (also called circus movement tachycar-dias) are produced by a continuous circular or looping pattern of myocardial activation.

Disruption of calcium homeostasis and arrhythmogenesis

genesis of arrhythmias in CPVT has further been highlighted by observations made in other animal models of the disease such as the R176Qþ/2 knock-in mice and Casq22/2 knock-out mice.24,25 Recently, Paavola et al.26 for the first time demonstrated DADs in monophasic action potential recordings in CPVT patients with RyR2 mutations. Interest-

AHA Science Advisory

Termination or cardioversion of arrhythmias Electrical cardioversion Administration of intravenous adenosine or other short-acting antiarrhythmic drugs Bedside procedures Insertion of central venous or pulmonary artery catheters from jugular or subclavian approach Insertion of transvenous pacemakers Carotid sinus massage Figure 1.

1o 2009 Eng -

observations; Observations of some cases of permanently slow pulse.21,22 1872 Duchenne de Bologne GBA (1806-1875). On localized electrical stimulation and its pathological and therapeutic application by induced and galvanized current, both interrupted and continuous.23 1882 von Ziemssen H (1829-1902).

Update on atrial fibrillation - ResearchGate

require termination by either direct electrical cardiover- arrhythmias may coexist with AF as seen in Fig. 2A D (same Recent epidemiological observations of atrial fibrillation

Electrophysiological Maneuvers For Arrhythmia Analysis

Electrophysiology of Arrhythmias-Reginald T. Ho 2019-06-26 Concise yet comprehensive, this practical guide to the diagnosis and ablation of cardiac arrhythmias in the electrophysiology laboratory is an indispensable resource for electrophysiologists and general cardiologists. It contains an extensive, unmatched collection of

a l Re a Journal ofs Facciorusso et al. Clinical Research

an electrical shock that is usually adverted as very painful [2]. In end-of-life patients, electrical storm (ES) often occur. ES is defined as 3 or more sustained episodes of VT or VF or appropriate shock of the AICD during a 24 hour period [3]. However, in some cases the frequency of shocks may increase so high that many shocks are

Self-terminating re-entrant cardiac arrhythmias: quantitative

Ventricular arrhythmias in the absence of structural heart disease. J Am Coll Cardiol. 2012 May 15;59(20):1733-44. [4] Cherry EM, Fenton FH, Gilmour RF Jr. Mechanisms of ventricular arrhythmias: a dynamical systems based perspective. Am J Physiol Heart Circ Physiol 2012 302(12) H2451-63.

New advances in nonpharmacologic therapy for atrial fibrillation

The observations on the mechanisms of AF have resulted in the development of a new electrical therapy that directed to eliminate the triggers and to modify the electrophysiologic substrate for the prevention and treatment of AF. Pacing for prevention of AF There are multiple potential mechanisms by which atrial pacing can theoretically prevent


The AFIB Report April 2001 Page 2 25 and 3 or 7.5% had a BMI over 30 thus being classified as obese. In comparison, a recent survey of over 17,000 US army personnel concluded that 54% of these young (75% under the age of 35) supposedly fit

Past and future aspects of clinical electrophysiology

pathological observations; observations of some cases off a permanently slow pulse [8, 9] 1872 Duchenne de Bologne GBA (1806 1875) On localized electrical stimulation and its pathological and therapeutic application by induced and galvanized current, both interrupted and continuous [10]

On Using Causal Knowledge to Recognize Vital Signals

electrical activity of the heart, i.e., there is no simple correspondence between signal features and individual electrical discharges in the heart. Our approach to the problem of building such a system is to construct a knowledge base stratified by several distinct knowledge bases (KBs) from different perspectives of the domain.

Management of supraventricular arrhythmias in adults with

Jun 16, 2016 analysis, electrical cardioversion was most frequently used for acute termination. It showed a success rate of 89%. Oral drug therapy (sotalol was used in 14 of 30 patients) was applied in 37% of patients and arrhythmia termination was observed in 88%. This high conversion rate likely includes some spontan-

The Journal of Physiology - Wiley Online Library

electrical behaviour of the heart have been described in detail in previous publications, some of which offer comprehensive reviews on the subject (Jacquemet et al. 2008; Plank et al. 2008; Trayanova, 2011, 2014). Pacing: anti-arrhythmia pacing for atrial fibrillation termination. The ability to construct multiscale models

Stretch-Induced Alternation of Cardiac Action Potential

mechanisms of mechano-electrical feedback (MEF) in the heart. With the abilities to modulate action potential duration (APD) during the systolic period and to trigger action potentials directly by diastolic stretch, SACs could play an important role on stretch-induced arrhythmias. The objective of this present study was to explore the

Enhanced self-termination of re-entrant arrhythmias as a

Ventricular tachycardias and fibrillation are potentially lethal arrhythmias that can result in sudden cardiac death. However, some episodes of ventricular tachycardia are observed to self-terminate; understanding of the mechanisms that produce self-termination could provide approaches to anti-arrhythmic therapies.

The Lyon Diet Heart Study

official termination of the study and publication of the initial findings so that they are now able to report their more extended observations. With the mean follow-up time of 46 months per patient, the initial remarkably beneficial effects of the experimental dietary program persisted compared with

The role of luminal Ca regulation in Ca signaling

early observations have led to a general conclusion that, rather than reflecting changes in electrical excitability, the bulk of mechanical restitution is determined by processes occurring at some later steps in the heartbeat generation, beyond that of electrical excitation. Some have even ascribed that refractoriness to altered me-

THE HISTORY Rhythms of the heart: The history OF ELECTRO- of

The concept of electrical termination of ventricular fibrillation (VF) dates back to the 19th century, but the first practical steps toward this goal were taken by Hooker, Kouwenhoven and Langworthy in 1933,(14) Naum Gurvich in Moscow in 1939(15) (who also pioneered DC defibrillation and biphasic waveforms) and Claude Beck in Cleveland in 1947.

Surgical Maze Procedures for Atrial Arrhythmias in

ventricular connection including a surgical maze procedure to treat the atrial arrhythmias (Mavroudis et al., 1998). 4. A history of maze surgery for atrial fibrillation Maze surgery for atrial arrhythmias is characterised by a stepwise development in pioneering during the early years. Some of th e present surgical procedures are being used

Electrocardiography and Repolarization Abnormalities in

arrhythmias in this setting is often covariate with the magnitude of QT prolongation. In this way, drugs that significantly prolong the QT interval can cause fatal arrhythmogenesis and sudden death. In response to these observations, formal evaluation of propensity for QT prolongation has become an important component of safety testing of new

Journal of Arrhythmia

However, in some instances, syncope may be due to more worrisome conditions (particularly that occur following spontaneous or electrical termination of VT or VF [7]. latter observations


The indications for treating arrhythmias by drugs or electrical means are discussed. The history of electrical termination of arrhythmias is reviewed and direct-current shock is compared with alternating current. Anaccount of the results ofconversion ofchronic atrial fibrillation of varied metiology to sinus

Electroporation as a bioelectric phenomenon word 97

passive electrical properties of living tissues. Furthermore, some remarks are given about the effects of electroporation on other bioelectri c phenomena such as cardiac arrhythmias. 1. Introduction Bioelectricity typically refers to the electromagnetic energy produced by living organisms. Such

The morphologic substrates for pediatric arrhythmias

insight into some of these particularly unusual arrange-ments.6 We will also discuss those findings which ac-count for most cases of heart block and preexcitation, and consider other observations which point to fibrosis as a substrate for the problems of rhythm known to occur in patients with tetralogy Fallot of We will also

echanisms of onset and rdiac rhythm studied by

place at the onset and termination of the cardiac arrhythmias has been useful in understanding the mechanisms of the arrhythmias in experimental animals as shown by Jioe, Harris, and Vv7ggers.r information concerning the onset and termination of abnormal rhythm in man is scarce, being dependent on chance ob-

Activation sequence during atrial flutter in dogs with

nonsustained arrhythmias induced by electrical stim-ulation in three dogs with normal atria. Materials and Methods Four mongrel dogs were prepared by creating the tricuspid insufficiency and, postoperativery, the pul-monary occlusion. Each dog was then studied for 2-12 months to make observations on the occurrence of

Atrial Fibrillation after Radiofrequency Ablation of Type I

Typical AFL and AF are both atrial arrhythmias and they frequently coexist in the same patient. Despite the substrate of AF and typical AFL being different in terms of location [(AFL right atrium (RA) / AF left atrium (LA)], some observations suggest a mechanistic interaction between them, especially during the initiation of arrhythmia.

Understanding EKGs: Identification of Arrhythmias

Normal Sinus Rhythm SA node is the pacemaker P wave is rounded, symmetrical, identical and a QRS follows each P PR interval is 0.12-0.20 sec and constant QRS complex will be positive or negative (depending on lead)


Cardiac pacing is a means of delivering an electrical stimulus to the heartmuscle to treat low cardiac output state (LCOS) caused by an arrhythmia to optimize cardiac output.

Possible pharmacological actions of magnesium in acute

Br. J. clin. Pharmac. (1991), 32, 3-10 Possible pharmacological actions ofmagnesiumin acute myocardialinfarction KENTL. WOODS DepartmentofPharmacologyandTherapeutics

A mathematical model of arrhythmogenesis in ventricular

ceases even before the termination of the stimulus signal. Results from the model simulations are consistent with clinical observations, suggesting an alternative mechanism for the generation of lethal ventricular arrhythmias in AVCs. Keywords: coupled cells, action potential, gap junction, arrhythmogenic ventricular

Self-terminating re-entrant cardiac arrhythmias: quantitative

Self-terminating re-entrant cardiac arrhythmias: quantitative characterization Alan P Benson 1 , Barrie Hayes-Gill 2 , Arun V Holden 1 , Rosa Matthews 1 , Aneela Naz 1 , Stephen Page 3 , Eleftheria Pervolaraki 1 , Edward Spofford 4 , Muzahir Tayebjee 3

Incidental Cardiac Arrhythmia Identification With Consumer

5. Close up of initiation and termination of occurrence viewed in HR tracing format 12 6. Showing a 10 second duration close-up of the termination of the SVT occurrence and the same image mirrored and inverted 13 7. Illustrating the same images from Figure 5, but the one on the right has been

Shock-induced termination of reentrant cardiac arrhythmias

some point in the course of the application of the shock. Empirical observations suggest that biphasic shocks are more efficient than monophasic shocks in terminating fibrillation. In this paper, by using a simplified mathe-matical model of cardiac tissue, which, however, includes a realistic response of the cells to large electric fields, we


some point in the course of the application of the shock. Empirical observations suggest that biphasic shocks are more efÞcient than monophasic shocks in terminating Þbrillation. In this paper, by using a simpliÞed mathe-matical model of cardiac tissue, which, however, includes a realistic response of the cells to large electric Þelds, we

Thyroid Hormones Modulate Occurrence and Termination of

ventricular arrhythmias incidence in clinic is not usually attributed only to hyperthyroidism itself (Aronow 1995). Most of the prominent effects of TH is thought to be mediated by thyroid nuclear receptors leading to changes at the transcription level, however, there is some evidence for their non-genomic action (not related to transcription)