Adjuvant MFOLFIRINOX Extends Survival In Pancreatic Cancer

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Treatment of pancreatic cancer neoadjuvant treatment in

intended resection and adjuvant chemotherapy represents the current standard of care. Despite substantial improvements in surgical treatment and intensified adjuvant treatment with more powerful regimens over the last years even clearly resectable pancreatic cancer still has an unfavorable prognosis with a high risk of relapse.

Treatment Approaches for Pancreatic Cancer

for Pancreatic Cancer Gauri Varadhachary, M.D. Professor University of Texas, M.D. Anderson Cancer Center Understanding Pancreatic Cancer Pancreatic Cancer Action Network Phoenix, Nov 19 , 2016 Terminology Pancreatic cancers: - majority are pancreatic adenocarcinomas - few are pancreatic neuroendocrine cancers - Lymphoma, sarcomas, others

Treatment Approaches for Pancreatic Cancer

Summary: Adjuvant therapy for pancreatic cancer djuvant therapy options increasingly A include systemic chemotherapy alone Some data supports 5-FU/LV (ESPAC-1, 3) Level 1 evidence supports adjuvant gemcitabine (CONKO-001), which improves disease-free and overall survival Relative contribution of chemotherapy vs. chemo-radiation

Treatment Approaches for Pancreatic Adenocarcinoma

Pancreatic Cancer Action Network www.pancan.org January 8, 2014 This educational webinar is sponsored by OncoGenexPharmaceuticals, Inc. Treatment Approaches for Pancreatic Adenocarcinoma Gauri R. Varadhachary Professor University of Texas, M.D. Anderson Cancer Center Webinar, Pancreatic Cancer Action Network January 8, 2014

Nanoliposomal irinotecan with fluorouracil and folinic acid

pancreatic cancer, previously treated with gemcitabine-based therapy. Added value of this study In patients with metastatic pancreatic cancer previously treated with gemcitabine-based therapy, nanoliposomal irinotecan in combination with fl uorouracil and folinic acid increased overall survival, progression-free survival, and time to treatment

Pancreatic Cancer: Treatment Approaches

Resected pancreatic cancer N=368 Oettle, JAMA 2007 Primary endpoint: Disease-free survival Stratification: Tumor stage: T1-2 vs. T3-4 Nodal status: N0 vs. N1 Resection status: R0 vs. R1 CONKO-001: Disease-Free Survival Observation: 6.9 mo Gemcitabine: 13.4 mo Log rank P <.001 HR 0.55 Months 0 12 24 36 48 60 72 84 ase-al 100% 75% 50% 25% 0%

PANCREATIC CANCER AND INFLAMMATION

PANCREATIC CANCER AND INFLAMMATION Christine Alewine, M.D., Ph.D. 5-YEAR SURVIVAL % BY STAGE 0 10 20 30 40 50 60 70 80 90 100 Adjuvant ­FOLFIRINOX/ FOLFOXIRI