Effects Of Cortisone On Ribosomal RNA Synthesis In Rat Liver
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Regulation of Nucleolar RNA Metabolism by Hydrocortisone
Similar studies on extra-nucleolar RNA produced smaller changes in the synthesis of this RNA fraction following hydrocortisone treatment and the pattern of RNA turnover in the chase experiments was not affected by the hormone. Much attention has been focused on hormone- induced changes in the synthesis of RNA [l-81.
Acute Decrease in RNA Polymerase Activity of Rat Thymus in
of incorporation of amino acids into ribosomal protein and RNA synthesis has been, demonstrated for liver, namely, a rise in RNA polymerase activity. Within 30 min following injection of cortisol into rats, liver nuclear preparations from hormone-treated animals showed an elevation of RNA polymerase activity significantly above that of
Commentary Hypothesis Research Letters
relation to urea synthesis (FEBS 1970) R. Hems Catecholamine control of enzymes involved in isocitrate oxidatton of rat liver mito- chondria (FEBS 1965) Y.i. Ku~insky, L. Y. Tra~nova, A.E. Medvedev Solubilized monomeric sarcoplasmic reticulum Ca pump protein: Phosphorylation by
Expression of the IGF-II mannose-6-phosphate receptor mRNA
For Northern blotting, a 2.4 kb cDNA for the rat IGF-II/ Mannose-6-phosphate receptor (clone K3. Morgan et al. 1987) was used and a 0.467 kb probe for the mouse 7S ribosomal gene, which should be expressed at an equal level in all cells (Balmain et al. 1982), was used as a control for RNA loading. Probe (10 ngs wer) e labelled by the random
Steroid Hormonesand the Pill
effects and imperfect control of men-struation. It was not until more bi-ologically active steroids which did not produce undesirable side effects be-came available that oralcontraception becamepractical The progestational agents are struc-turally related to progesterone and fall into two classes-progesterone deriva-.6 NOVEMBER1965 tives and
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in the presence of estrogen as well as increased RNA synthesis in rat uterus following injection of estrogen. Agarwal et aZ (25) measured an increase in precursor uptake in the acid soluble pool of rat liver after cortisone treatment. A similar increase in RNA precursor uptake has also been reported by many other workers (26-28).
Comparative Effects of Actinomycin and Ionizing Radiation on
or no effects. The induction of serine dehydrase in rat liver is initially sensi-tive and later resistant to the effects of actinomycin as well as 7-radiation. Tyrosine transaminase induction by cortisone is sensitive to actinomycin but is completely resistant or, in some cases, actually stimulated by ioniz-ing radiation.
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1) Effects on RNA synthesis It has been shown that the action of estradio1 12, testosterone 13, hydrocortisone1q, growth hormone15, cortisone 16, and aldosterone17-20 is blocked by inhibitors of RNA synthesis. Hence it appears that the synthesis RNA is an early event in the mechanism of action of many hormones.
Suppression Development Liver Origin Iridescent L-Tyrosine
cortisone-induced increase in TT activ-ity has been shown to be due to syn-thesis of new enzyme molecules (11), and its inhibition by actinomycin (10) suggests that, like the developmental increase, it is RNA-dependent. Actidione appears to have a variety of effects on RNA synthesis. Thus it inhibits synthesis of ribosomal RNAin yeast (12. 13
69-10,601 JAMES, Gordon Price, 1936- STEROID HORMONES AND
increase RNA and protein synthesis in chick oviduct (103). A single injection of cortisol has beer. shown to stimulate protein synthesis in rat liver following an increase in RNA synthesis (106).