Diverse Biological Effect And Smad Signaling Of Bone Morphogenetic Protein 7 In Prostate Tumor Cells
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Diverse Biological Effect and Smad Signaling of Bone
Diverse Biological Effect and Smad Signaling of Bone Morphogenetic Protein 7 in Prostate Tumor Cells Shangxin Yang, 1Chen Zhong,2 Baruch Frenkel, A. Hari Reddi,3 and Pradip Roy-Burman1,2 Departments of 1Biochemistry and Molecular Biology and 2Pathology, Keck School of Medicine, University of Southern California,
Review Roles of Smads Family and Alternative Splicing
homeostasis, and tumor development Functional study of TGF -β signaling pathway and Smads role is vital for certain diseases such as cancer. Alternative splicing produces a diverse range of protein isoforms with unique function and the ability to react differently with various pharmaceutical products.
Bone morphogenetic protein-7 is a MYC target with prosurvival
proliferation in p53-deﬁcent breast cancer cells when knocked down (Yan and Chen, 2007). Although apparently contradictory, these data reﬂect the complex-ity of the BMP/SMAD signaling pathway (Ye et al., 2009), leading to diverse heterogeneous cellular re-sponses, which can be tissue- and cell type-speciﬁc and
Biological effects of BMP7 on small-cell lung cancer cells
Bone morphogenetic protein 7 (BMP7), a member of the BMP family of signaling molecules, has been implicated in various types of cancer, particularly prostate cancer and breast cancer. However, there is little knowledge of the function of BMP7 in SCLC. The aim of the present study was to investigate the biological function of recombinant
DNA Promoter Hypermethylation of Genes Related to
On the other hand, transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) signaling plays a crucial role in a complex and broad biological spectrum including cell proliferation, differentiation, migration, immune response, angiogenesis and apoptosis [6,7].
University of Groningen Human mucosal IgA in health and
7.1 Introduction Bone morphogenic protein (BMP) is a member of large TGF- family ligands. Originally BMP was identified as a putative morphogen for bone formation (Reddi, 1994) and later this protein emerged as an important signaling mediator during embryonic nervous system patterning(Liu and Niswander, 2005). BMP forms a
The BMP signaling pathway leads to enhanced proliferation in
BMP2/4/7 was related to the invasion and metastasis of prostate cancer, melanoma, gastric cancer, chon-drosarcoma, and bladder cancer [10 15]. Compared to normal lung tissues, BMP2 is highly expressed in 98% of lung cancer . The importance of BMP signaling has also been reported in ovarian cancer, although its precise mechanisms in the
The Dual Role of Bone Morphogenetic Proteins in Cancer
Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth factor proteins that belong to thetransforminggrowthfactor-b(TGF-b)familyandarehigh-ly associated with bone formation and disease development. Aberrant expression of various BMPs has been reported in several cancer tissues. Biological function studies have