Induction Of Nitric Oxide Synthase In The Neo‐vasculature Of Experimental Tumours In Mice

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Expression of Inducible Nitric-oxide Synthase and Intracellular

by DM Fries 2003 Cited by 81 Protein Tyrosine Nitration in Vascular Smooth Muscle Cells. ROLE OF REACTIVE OXYGEN SPECIES* nitric-oxide synthase (iNOS) protein expression and in.

Induction of haem oxygenase-1 by nitric oxide and - CORE

by K Doi 1999 Cited by 248 production by experimental tumours in mice has been implicated in maintenance of tumour blood flow in the neovasculature, and.

Differential Contribution of Acute and Chronic - PLOS

by CT Rodrigues Viana 2015 Cited by 8 Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice. J Pathol. 1993; 171(4):311 9.

Nitric Oxide Synthase II Is Expressed in Severe - IOVS

by F Sennlaub 1999 Cited by 52 Inducible nitric oxide synthase (NOS-II) is expressed in many A mouse model of corneal neovascularization induced by chemical cauterization was.

Obstacles Posed by the Tumor Microenvironment to T 

by KG Anderson 2017 Cited by 304 enzymes nitric oxide synthase (NOS) and arginase (ARG) are esis, but the induced neovasculature is often abnormal and fails.

Vascular nitric oxide conditions acute tumor re-oxygenation

by P Sonveaux Cited by 110 The ultimate goal of radiotherapy is to induce irreversible damages in genetically unstable, fast- growing cancer cells while minimizing the 

Nitric Oxide Synthase Activity in Human Thyroid - J-Stage

by E Takeuchi 2001 Cited by 3 Moreno, V., Hart, I., Piper, P. J. and Polak, J. M.: Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice. J. Pathol.

In Vivo Tumor Growth of Lewis Lung Carcinoma by Promotes

by Y Saijo 2002 Cited by 266 human IL-1ß gene into mouse Lewis lung carcinoma (LLC) cells and subsequently and showed more abundant vasculature (250%, vs LLC/neo; p < 0.05), 

Metformin stimulates ischemia-induced revascularization

by N Takahashi 2015 Cited by 31 model of ischemia-induced angiogenesis. Methods: For comparative purposes, randomly selected wild-type (WT) mice or endothelial nitric oxide synthase (eNOS).

Targeted gene therapy in radiotherapy

Department of Experimental Oncology, Institute of Oncology Ljubljana, Slovenia radiation-induced apoptosis (wild-type p53 Nitric Oxide Synthase; TNF- α, Tumor Necrosis Factor-α; IL-12, Interleukin-12; PSA, Prostate Specific therapy and vascular-targeted therapy. and radiotherapy was reported in a mouse.

Caveolin-2-Deficient Mice Show Evidence of Severe

and Department of Cell Biology and The Albert Einstein Cancer Center,4 Albert Einstein ondary to constitutive endothelial nitric oxide synthase activa-.


by JC Lopez-Talavera 1995 Cited by 238 tal-hypertensive rats, induced by partial ligation of the portal vein (PVL), were used. role for endogenous nitric oxide in the regulation of blood.

The role of nitric oxide in tumour progression

by D Fukumura 2006 Cited by 1181 Tumour cells often express inducible NO synthase (iNOS) and in some cases endothelial NOS (eNOS) and neuronal NOS (nNOS). Tumour vascular endothelial cells.

Nitric Oxide System in Needle-Induced Transmyocardial

by T Saito 2001 Cited by 9 inducible form of nitric oxide (NO) synthase (iNOS) by various insults including myocardial from the coronary artery ligation, sham rats underwent.

Tristetraprolin Inhibits Ras-dependent Tumor Vascularization

by K Essafi-Benkhadir 2007 Cited by 112 Vascularization by Inducing Vascular Endothelial Growth. Factor mRNA Degradation 2004), and inducible nitric-oxide synthase (Fechir et al.,.

Endothelial NT-3 Delivered by Vasculature and - Cell Press

by AC Delgado 2014 Cited by 158 Neural Stem Cells through Nitric Oxide Induction brain of adult Ntf3+/lacZneo mice (Farin˜ as et al., 1996) was consis-.

Inducible Nitric Oxide Synthase Mediates Retinal Apoptosis in

by F Sennlaub 2002 Cited by 156 ation and to improve its vascularization. Key words: inducible nitric oxide synthase; apoptosis; retina; knock-out mice; ROP; ischemia; peroxynitrite; 

Chemopreventive Effect of Brazilian Green Propolis on

by RN Pereira-Filho 2014 Experimental Dermal Carcinogenesis in Murine Model Cancer induction was performed in the back of the mice by topical application of DMBA.

Interleukin-1β-induced iNOS expression in human - NOPR

by K Ravichandran 2011 on iNOS expression and key signaling molecules in human lung carcinoma A549 cells and established established that iNOS (nitric oxide synthase) is one.

Gr-11CD11b1 cells facilitate Lewis lung cancer recurrence by

by T Liu 2014 Cited by 20 cancer recurrence by enhancing neovasculature after local irradiation elevated expression of iNOS (inducible nitric oxide synthase) in.

Nitric oxide synthase inhibition results in synergistic - Nature

by JHW de Wilt 2000 Cited by 61 Polak JM (1993) Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice. J Pathol 171: 311 319 de Wilt JHW, Manusama ER, 

Nitric oxide synthase inhibition irreversibly decreases - CORE

by M RE 1995 Cited by 40 has involved the induction of tumour hypoxia following the oxide synthase in the neo-vasculature of experimental tumours in mice. J. Pathol.

Inducible Nitric Oxide Synthase Mediates Hypoxia-Induced

by T He 2007 Cited by 29 Inducible nitric oxide synthase Hypoxia-inducible factor-1 α Phosphatidylinositol 3-kinase/Akt Vascular endothelial growth factor Oxygen-induced retinopathy.

Nitric oxide synthase activity and expression in human

by S Moochhala 1996 Cited by 129 M. (1993) Induction of nitric oxide synthase in the neo-vasculature of experimental tumours in mice. Cancer Res., 171,. 311-319. 4.Thomsen,L.L., Lawton.

Nitric oxide - Neurology

18 Oct 2011 Nitric oxide (NO) is a gaseous chemical transmitter that is produced from the amino acid L-arginine by the members of the NO synthase (NOS) 

A Novel Anti-Vascular Therapy for Cancer

by J Folkman 2004 Cited by 29 a novel form of experimental anti-vascular therapy for cancer.1 In mice bearing large Because endostatin inhibits endothelial nitric oxide synthesis.

Tumor Microenvironment

by G Baronzio Cited by 13 Nitric oxide released by macrophages may nitrosylate Iκb and dissociate it Roberts WG, and Palade G: Neovasculature induced by vascular endothelial 

The physiological role of endoglin in the cardiovascular system

23 Jul 2010 ized by vascular malformations; 2) endoglin knockout mice die at expression and activity of endothelial nitric oxide synthase, 

Endothelial-Tumor Cell Interaction in Brain and CNS

by M Peleli 2020 Cited by 3 mediators, like the gasotransmitter nitric oxide and different types Tumors achieve their vascularization by inducing new blood vessel 

Overexpression of iNOS Gene Suppresses the - In Vivo

Background: The inducible nitric oxide synthase. (iNOS) is associated with inflammatory reported that NO can induce apoptosis in tumor cells by.

Hypoxic tumor cell radiosensitization - Oxford Recovery Center

by M DE RIDDER 2008 Cited by 42 oxide synthase (iNOS) may be induced by bacterial LPS or its derivate lipid A, is expressed the neovasculature is morphologically and functionally ab-.

Role of Nitric Oxide in Gene Expression Regulation - MDPI

by P de la Cruz-Ojeda 2021 NO regulates critical aspects of cancer induction and progression (Figure 1). In fact, patients with hepatocellular carcinoma (HCC) display high 

Inducible nitric oxide synthase mediates the change from - JCI

Here we show that inducible nitric oxide synthase (iNOS) is expressed in the ischemic retina. Using iNOS knockout mice and the iNOS inhibitor 1400W, 

Induction of Hypoxia in Experimental Murine Tumors by the

by PJ Wood 1994 Cited by 54 The nitric oxide synthase inhibitor [email protected](NOARG) was associated neovasculature induced by sponge implantation (13, 14).

bearing mice. - International Nuclear Information System (INIS

by NMA Mesalam Ehrlich ascites carcinoma (EAC) is one of the experimental breast from L-arginine by nitric oxide synthase (NOS), a family of ubiquitous enzymes.

Targeting of prostate-specific membrane antigen for radio

by A Morgenroth 2019 Cited by 9 For in vivo experiments, NUDE mice were xenografted with triple-negative breast cancer cells cells of tumor-associated neo-vasculature, with no endothe-.

Bone marrow-derived circulating endothelial - PNAS

by S Purhonen 2008 Cited by 443 2+) stem cells mobilized from the BM by VEGF or tumors, and it is formation of neovasculature within matrigel plugs in mice (13).

Angiogenesis and hepatocellular carcinoma - Journal of

by D Semela 2004 Cited by 418 model in American Cancer Institute rats used in our laboratory, image tic cells and tumor neovasculature has been described in. HCC [157 159].

Infection and Nitric Oxide - JSTOR

by JB Hibbs Jr 2002 Cited by 94 The significance of cytokine-induced nitric oxide synthesis during innate and transplanted tumors in mice in addition to inducing the ex-.

The DDAH/NOS pathway in human prostatic cancer cell lines

by L Vanella 2011 Cited by 29 development of neovasculature around the tumor. This process, isoforms of nitric oxide synthases (neuronal NOS, endothelial.

Effect of 17-β Estradiol on the Expression of Inducible Nitric

by SN Ostad Cited by 7 The results of these experiments may indicate that increasing of iNOS Keywords: Breast cancer; Nitric oxide synthase; Tamoxifen; Estrogen; Estradiol.


by QS Ng 2008 nitric oxide synthase inhibitor N-nitro L-arginine (LNNA). Patients with NO mediates VEGF induced hyper-permeability in tumour vessels and.

Eicosapentaenoic acid induces neovasculogenesis in human

by CC Chengf 2014 Cited by 17 consumption significantly induced the formation of new blood vessels (neovasculogenesis) tion of the endothelial nitric oxide synthase (eNOS) protein.

Download PDF - Vessel Plus

28 May 2020 oxide synthase leading to increased production of nitric oxide and Cell signalling pathways of hypoxia-induced tumour angiogenesis.

Nitric Oxide: The Forgotten Child of Tumor - SleepClinic

by BS Rizi 2017 Cited by 53 product of the nitric oxide synthase (NOS) reaction that For example, cancer cell-derived NO induces chronic inflammation in the TME of 

Induction of nitric oxide synthase gene by interleukin-1 beta in

by M Tsujino 1994 Cited by 177 mechanism by which cytokines induce nitric oxide synthase against the N-terminal fragment of mouse iNOS revealed the expression of 130-kD iNOS-like 

XTT Cell Viability - USF Scholar Commons - University of

by J Lo 2004 Cited by 1 Figure 3.13 Tumor size (mm3) of control and PH treated mice. nitric oxide synthase in cells treated with PH3 and PH11.

Vascular Endothelial Growth Factor-C - The American Journal

ated by pretreatment with the nitric oxide synthase inhibitor N -nitro-L-arginine methyl ester. therapeutic12 15 and tumor-induced angiogenesis.16 19.

Clinacanthus nutans - SciELO

by AK Azemi 2021 Nitric oxide (NO) is produced by endothelial NO synthase (eNOS) in the endothelial cells through vascular endothelial dysfunction by inducing oxidative.

Middle T Antigen-tranfformed Endothelial Cells Exhibit an

by D Ghigo 1995 Cited by 50 growth factor, which induces migration of vascular endothelial cells (21). 10 Middle TAg Expression and Endothehal Nitric Oxide Synthase Activity