Radiation Therapy With Survival Among Patients With Dementia
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UT SOUTHWESTERN THE TARGET
The prognosis for patients with brain metastasis is generally poor, with median survival of only a few months.3 There are several validated prognostic factors in patients with brain metas-tases. In the recursive partitioning analysis (RPA) performed on 1,200 pa-tients from multiple Radiation Therapy Oncology Group (RTOG) trials, the
Defining a Standard Set of Patient-centered Outcomes for Men
3.3. Survival and disease control Knowledge of treatment efficacy is crucial for decision making for most men with PCa . We selected overall survival, cause-specific survival, metastasis-free survival, and biochemical recurrence free survival as measures of cancer eradication for the Standard Set. Although some of
Localized Field External Beam Radiation Therapy after
Among patients, 16 of them (51.6%) had supra-tentorial lesions and the other 15 patients (48.4%) represented by infra-tentorial lesions. The mean maximal tumor dimensions determined by MRI were 3.1 cm ranging from 1.3 to 4.6 cm, with 58.1% having tumors ≥ 3 cm. Radiation therapy The median time to start radiation therapy was 4 weeks (range,
Memantine for Prevention of Brain Irradiation Induced
patients may receive WBRT with a longer expected survival and possibly with higher burden of NC decline. Despite the clear emphasis on avoiding or delaying WBRT, nearly one fourth of patients with brain metastases in the United States continue to receive it.15 This percentage is likely to be sig-
The patient's perspective on breast radiotherapy: Initial
aged>90 years and those with dementia were excluded. Patients were treated in the setting of a previously described multidisciplinary breast cancer clinic. 31 As a standard, patients were seen by radiation oncology, medical oncology, and breast surgery clinicians at the time of their initial diag-nosis before any therapeutic intervention
Choosing Wisely? It s Complicated!
WBRT, focal radiation therapy, chemotherapy, or surveil-lance without treatment. There is evidence to suggest that WBRT can decrease the risk of relapse, but it can also be associated with neurocognitive problems, and randomized studies haven t shown long-term survival benefit. We discussed more recent data on focal radiation therapy and
Limited-Stage Small Cell Lung Cancer: Is Prophylactic Cranial
to 70 Gy. Radiation therapy was initiated with cycle 1 or cycle 2 of chemotherapy. Patients enrolled on protocol were in some instances treated with twice daily thoracic radiation. In some exceptions, patients were managed with surgical resection, although generally among those with early-stage tumors, resection was only attempted
Predictors of Poor Sleep Quality Among Head and Neck Cancer
is often correlated with depression among cancer patients, and the majority of depressed patients report insomnia.7,8 Depression is also correlated with nicotine and alcohol use, which are both common among head and neck cancer patients and have an adverse effect on sleep quality.9,10 Radiation therapy to treat head and
1872 Original Article Stereotactic body radiation therapy for
patients do not receive a biopsy prior to treatment with stereotactic body radiation therapy (SBRT). This study seeks to analyze the overall survival (OS), local control, and toxicity rates for such patients. Methods: This retrospective review included patients empirically treated with SBRT for presumed non-metastatic NSCLC at a single institution.
survival and disease-free survival were all higher with beta-blocker intake, although there was no association found with locore - gional progression-free survival. These associations remained after adjusting for a number of factors, including age, tumor stage, performance status, alternative treat - ments and radiation dose, among others.
Complications in Long-Term Survivors of Ewing Sarcoma
signiﬁcant increase in the number of survivors among patients who were diagnosed in the 1970s compared with the 1960s (P 0.01). This continued to be true when the median number of patients, which was de-FIGURE 1. The evolution of the 5-year survival rate of patients with Ewing sarcoma over the last 40 years.
Clinical Patterns and Biological Correlates of Cognitive
cranial radiation. 2. Diagnose the patterns of cognitive dysfunction encountered in patients treated for cancer. 3. Evaluate cranial imaging abnormalities consistent with nervous system toxicity from cancer therapy. 4. Explain the novel concepts of the cell-biological consequences underlying chemotherapy- and radiation therapy
Advance Care Planning Needs in Patients With Glioblastoma
Patients With Glioblastoma Undergoing Radiotherapy To the Editor: Despite multimodality treatment including surgery, radiation, and chemotherapy, glioblastoma of the brain remains a terminal and life-altering diagnosis, with a median survival of less than two years. Patients with glioblastoma have the concurrent diagnoses of a
Ofﬁ cer shot at courthouse thanks Sunnybrook for life-saving
of radiation, hypofractionated radiation therapy provides good preservation of the physical appearance of the breast. A regi-men of conventional whole-breast radiation therapy is 50 Gy delivered in 25 sessions over five weeks, while a regimen of hypofraction-ated radiation therapy is between 40 and 42.5 Gy delivered in 16 sessions over 3.5 weeks.
Issue No. 2, May/June 2015 Therapy improves survival for
Therapy improves survival for younger brain cancer patients. Single dose, high precision radiation therapy, known as Stereotactic radiosurgery, im-proved survival by 65 per cent for younger patients with limited brain metastases (cancer spread), compared to similar patients who received stereotactic radiosurgery followed
Inpatient Physical Therapy For A Patient With Dementia After
Both procedures have similar survival rates but limb sparing surgery results in higher 59 independent functioning. 4 60 There is limited research in the literature regarding dementia involving motor planning 61 deficits and physical therapy. However based upon the interventions provided by physical
Cancer and dementia: Two sides of the same coin?
cancer and dementia, that is patients with dementia have a decreased risk of subsequently being diagnosed with cancer, and cancer patients have a lower risk of dementia.5-20 Impor-tantly, this association is not restricted to cancer of the cen-tral nervous system (CNS) or to long‐term adverse effects of cancer treatments.
COVER STORY Could it be Intraocular Lymphoma?
Radiation therapy is currently used much less frequently than in the past. Whole-brain radia-tion in conjunction with chemotherapy in older patients is now recognized to be associated with a high incidence of severe dementia and little improvement in survival compared with chemotherapy alone. Use of radiation to the eyes of patients with ocular
Cost-Effectiveness of Adding Androgen Deprivation Therapy to
patients and examined 3 strategies: active surveillance, radiation therapy, and the combination of radiation therapy and ADT. Despite ADT-associated costs and long-term side effects, ADT was cost-effective in men with prostate cancer who received radiation therapy at $127,900 per quality-adjusted life-years. What this study adds
Supplement to: 1. Original protocol, final protocol, summary
Survival for untreated patients with brain metastases is generally less than seven weeks. Standard palliative treatment, including glucocorticoids and whole brain radiation therapy (WBRT), extends median survival to three to six months by preventing or delaying neurologic progression [Posner 1992]. Radiation Therapy Oncology Group (RTOG)
Solitary Brain Metastases - CHEST Home
in progressive white matter change and dementia. SuRGICAL REsECTION There is little question that surgery with radiation pro vides more effective palliation of a single brain metastasis than does radiation therapy alone. Two studies have evalu ated the impact of surgery on the disease course of patients
The impact of cancer therapy on cognition in the elderly
and ﬂuorouracil chemotherapy, radiation therapy and was on exemestane when she was evaluated. We will also brieﬂy review the literature of cancer therapy-related cognitive impairment. Keywords: cognition, chemotherapy, chemobrain, geriatric oncology, elderly, cancer INTRODUCTION Cancer treatment is a ﬁeld that has made great advances in the
Correlation between the Ki-67 proliferation index and
The median survival time was 516 days for all patients, and the survival rates did not or radiation therapy. Among the 19 patients, an advanced age or had dementia. Response to radiation
Correlation between the Ki-67 proliferation index and
therapy or radiation therapy. Among the 19 patients, bronchoscopic biopsy specimens were collected from 16 patients and percutaneous lung biopsy specimens were collected from 3 patients. Samples were stained with haematoxylin and eosin and the Ki-67 antibody MIB-1 clone (DAKO, Glostrup, Denmark) was used to detect Ki-67 expression.
How Does Androgen Deprivation Therapy Affect Mental Health
with prolonged survival, the effects of ADT on mental health, such as cognitive dysfunction and dementia risks, have received more attention . This review ar-ticle summarizes articles dealing with the association of ADT with cognitive dysfunction, including dementia risks, in PC patients treated with ADT. MAIN BODY 1.
Risk of Alzheimer s Disease Among Senior Medicare
To assess the relative risk of Alzheimer s disease (AD) among patients with prostate cancer who received androgen deprivation therapy (ADT), after adjustment for other cancer therapies. Methods Data from demographics, survival, diagnoses codes, procedure codes, and other information about
Neurocognitive Function of Patients with Brain Metastasis Who
the 1990s, it has come to be increasingly used worldwide for patients with no more than a few brain metastases. A recent prospective randomized trial from the Radiation Therapy Oncology Group (RTOG) showed a small but significant improvement in the survival of patients that had up to 3 metastases with good
PHYSICIANS AND PATIENTS SHOULD QUESTION IN HOSPICE AND
a single-fraction dose of palliative radiation therapy for patients who have uncomplicated painful bone metastasis rather than multiple fractions, as is often done currently. The single fraction is supported by 2011 guidelines from the American Society for Radiation Oncology and is less burdensome for the patient and family. (For a complete
Beyond the Barrier: Targeted Radionuclide Therapy in Brain
Aug 01, 2019 radiation therapy or systemically administered pharmaceutics. External beam radiotherapy is the most commonly applied treatment option and can be provided under the form of radiosurgery for single or limited number of tumor sites, or whole-brain radiotherapy (WBRT) for patients with multiple lesions where focal treatments are ine ective.
Racial Disparities in Treatment and Survival Among Women With
Suboptimal treatment may compromise the survival beneﬁts of adjuvant chemotherapy. We analyzed the association of race and survival with duration of treatment and number of treatment cycles among women receiving chemotherapy for early-stage breast cancer. Patients and Methods
Radiotherapy for Glioblastoma in the Elderly
The new engl and journal of medicine 1528 n engl j med 356;15 www.nejm.org april 12, 2007 T he incidence of malignant glioma is increasing among elderly patients,1-3 whose advanced age has been
Cancer The Impact of Preexisting Mental Health & Prevention
and II patients only and receipt of chemotherapy and radiation therapy was analyzed among stages III and IV patients only. In terms of cancer survival, we ﬁrst analyzed overall survival by preexisting mental health disorder status using Kaplan Meir curve and log-rank test. Multivariate Cox proportional hazards
Stereotactic Radiosurgery for the Management of Brain Metastases
lesions. Among patients with a single lesion, sur - vival was significantly improved in patients as - signed to undergo stereotactic radiosurgery after whole-brain radiation therapy (median, 6.5
Ethics of artificial nutrition and hydration at end of life
Mortality among tube-fed patients is high. Cohort study of 46,000 NH patients over age 65, with advance cognitive impairment and a new need for assistance in feeding, controlled for confounders. median survival 177 days among tube-fed and hand-fed Finucane, JAMA 1999;282:1365-70; Teno, J Am Geriatr Soc 2012;60:1918-21 NO
Outcomes and Diffusion of Doxorubicin-Based Chemotherapy
younger patients, although to our knowledge little is known about the patterns of use and the effective-ness of chemotherapy among elderly patients in the general population.5 Recent studies among elderly patients have demonstrated that age bias may inter-fere with their receiving optimal cancer therapy.5,8 10
Causes for the Undertreatment of Elderly Breast Cancer
The purpose of this study was to determine the rate and causes of elderly patients not receiving standard therapy. STUDY DESIGN: A random sample of 500 patients was reviewed for age, cancer stage, surgical, radiation, cyto-toxic or hormonal chemotherapy, number and type of comorbidities, type of therapeutic deficiencies, and their causes.
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Jul 31, 2019 inhibitors (TKIs) and withholding of whole-brain radiation therapy (WBRT) is controversial. We aim to investigate the impact of WBRT on overall survival (OS). After screening 1384 patients, a total of 141 EGFR-mutated patients with NSCLC and BM were enrolled. All patients received EGFR-TKIs between 2011 and 2015.
MRI Finding in Delayed Extensive Brain Lesions after
Radiation therapy can prolong survival of cancer patients to improve their quality of life, but it occasionally induces the human body, including brain radiation injury. Radia-tion-induced brain damage is considered an uncommon delayed complication among cancer survivors who have undergone whole brain irradiation for brain tumors [1-5].
Treatment Outcomes in Stage I Lung Cancer: A Comparison of
Body Radiation Therapy In Response: We appreciate the interest that our article highlighting long-term outcomes in patients undergoing surgery or stereotactic body radiation therapy (SBRT)1 has generated among providers caring for patients with lung cancer. Dr. Poullis, in his letter to the editor, and several
SURVIVAL AND AMBULATORY FUNCTION AFTER ENDOPROSTHETIC
and following excision of the lesion with a clear margin, in another 20. Postoperative radiation therapy was carried out on 27 limbs (intralesional 13, marginal 6, wide 8). Chemotherapy was administered to 19 patients after discussion with the medical oncologist. The cumulative survival rates at 6 and 12 months were