Nutrient Deprivation Induces Autophagy As Well As Apoptosis In Chinese Hamster Ovary Cell Culture

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AutophagyRegulatesPancreaticBetaCellDeathinResponse

evident prior to the onset of cell death. Inhibition of autophagy prolonged cell survival and delayed cell death. Nutrient depriva-tion increased autophagy in MIN6 cells and mouse and human islets after starvation. Autophagy inhibition partly prevented aminoacidstarvation-inducedMIN6celldeath.The invivoeffects of reduced autophagy were studied

The Death of Human Cancer Cells Following Photodynamic

The form of cell death induced by autophagy (called Type II cell death) is distinct from apoptotic Type I cell death (7,8). Photodynamic therapy is a potent inducer of apoptosis in many types of cells (11). We have reported that PDT with the phthalocyanine photosensitizer, Pc 4, induces apoptosis in mouse lymphoma L5178Y-R (12), Chinese hamster

MEETING ABSTRACT Open Access Growth and death kinetics of CHO

cell necrosis and apoptosis occurred, while this cellular Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture

Autophagy and apoptosis in Chinese hamster ovary cell culture

Addendum to: Hwang SO, Lee GM. Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture. Biotechnol Bioeng 2007; DOI: 10.1002/bit.21589 [Autophagy 4:1, 70‑72; 1 January 2008]; ©2008 Landes Bioscience

PHOSPHATIDYLCHOLINE BIOSYNTHESIS IS INVOLVED IN AUTOPHAGY

2.2 Cell culture CHO Chinese hamster ovary CHT High affinity choline transporters NAF-1 Nutrient deprivation autophagy factor-1 NFE2L2 Nuclear factor