Dose‐Dependent Gingival Overgrowth Induced By Cyclosporin In Rats

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Gingival Hyperplasia in Dogs Induced by Oxodipine, a Calcium

to describe gingival hyperplasia in dogs induced a dose-dependent manner by a calcium channel blocker. INTRODUCTION Drug-induced hyperplastic changes in the gingiva of man have been described for diphenylhydantoin (1 S), Nifedipine (1, 17,2 l), cyclosporin A (22) and valproic acid (24). In laboratory animals, this man-

ORIGINAL RESEARCH Morphological Comparison of the Changes in

Both drugs, tacrolimus and sirolimus, induced gingival enlargement in the male albino wistar rats. However, the tacrolimus administered group showed a two-fold greater increase in the gingival dimensions compared to the sirolimus administered group. Clinical significance:

Differential Diagnosis: Gingival Hyperplasia Calcium Channel

11. Schincaglia GP, et al. Cyclosporin-A increases type I procollagen production and mRNA level in human gingival fibroblasts in vitro. J Oral Pathol Med 1992;21(4):181-5. 12. Fu E, et al. Dose-dependent gingival overgrowth induced by cyclosporin in rats. J Periodontol 1995;66(7):594-8.

Drug-Induced Gingival Hyperplasia

overgrowth of gingival tissue, which can lead to gingival bleeding, pain, teeth displacement, and periodontal disease. Race No racial predilection exists for the onset of drug-induced gingival overgrowth. Sex No sexual predilection exists for drug-induced gingival overgrowth, although in one study, males were 3 times