Epigenetic Regulators Of Mesenchymal Stem/Stromal Cell Lineage Determination

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Meeting report of the 2016 bone marrow adiposity meeting

mesenchymal cells at different levels of lineage matura-tion. These paracrine events clearly drive self-renewal and cell fate of mesenchymal cells, and may favor normal lineage progression (programming) or trans-differentiation (re-programming) by altering epigenetic events, as well as expression of both DNA- and RNA-binding gene regulatory

Meeting report of the 2016 bone marrow adiposity meeting

nisms of self-renewal and cell fate determination in the mesenchymal lineage. Recent studies indicate that regulation of cell fate in SSCs may be central to maintaining balanced levels of bone marrow adiposity. This premise is based on sev-eral key observations made in vivo in mouse models with functional mutations that affect either osteogenic

Epigenetic Regulators of Mesenchymal Stem/Stromal Cell

Epigenetic Regulators of Mesenchymal Stem/Stromal Cell Lineage Determination Dimitrios Cakouros1,2 & Stan Gronthos1,2 # The Author(s) 2020 Abstract Purpose of Review Although many signalling pathways have been discovered to be essential in mesenchymal stem/stromal

Epigenetic Regulators of Mesenchymal Stem/Stromal Cell

Epigenetic Regulators of Mesenchymal Stem/Stromal Cell Lineage Determination Dimitrios Cakouros 1,2 & Stan Gronthos 1,2 # The Author(s) 2020 Abstract Purpose of ReviewAlthough many signalling

Osteogenic Stimulation of Human Adipose‐Derived Mesenchymal

biological fate of human mesenchymal stromal cells have been studied. Preliminary work from our research group and others has established the bone-anabolic properties of the epigenetic drugs GSK126 and sulforaphane both of which may have potential use as stem cell modulating agents in autologous therapy for aging patients [18 20].

Cell Stem Cell Article

epigenetic regulatory mechanisms that govern adipogenic- and osteogenic-specific genes remain largely elusive, they are the crucial missing links in understanding extracellular signaling and lineage-specific decisions during MSC differentiation. One 50 Cell Stem Cell 11, 50 61, July 6, 2012 ª2012 Elsevier Inc.