Tracer Kinetic Modeling In Myocardial Perfusion Quantification Using MRI

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EDITORIAL POINT OF VIEW Quantification of myocardial blood flow

ment of myocardial perfusion with PET, in particular, 15O-water,9] 13N-ammonia,10 the potassium analog 82Rb.11 Recently also new 18Fluoride-labeled12,13 as well as 68Ga-labeled compounds have been tested.14 Currently, 15O-water and 13N-ammonia are the tracers most widely used for the quantification of myo-cardial perfusion with PET. Tracer

Impact of motion and partial volume effects correction on PET

Aug 12, 2016 PET is an established modality for myocardial perfusion imaging (MPI) which enables quantification of absolute myocardial blood flow (MBF) using dynamic imaging and kinetic modeling. However, heart motion and partial volume effects (PVE) significantly limit the spatial resolution and quantitative accuracy of PET MPI.

Stress MRI for Evaluation of CAD

Introduction: A wide range of post‐acquisition approaches is used to assess myocardial perfusion, ranging from visual evaluation and scoring, to full quantification of myocardial blood flow using tracer‐ kinetic modeling, or model‐independent approaches.


Imaging (MRI) to perform diagnostic imaging at different physical scales, from physiological to cellular and finally at the molecular level. Chapter 2 illustrates the ability of Dynamic Contrast Enhanced Magnetic Resonance Imaging or DCE-MRI to measure an important

Methodological aspects of quantitative cardiac molecular imaging

MRI-based quantitative MBF measurement based on widely available acquisition protocols is not yet ready for clinical introduction. Keywords: PET, cardiac amyloidosis, 11C-PIB, retention index, standardized uptake value, PET-MR, MRI, myocardial blood flow, 15O-water, quantification, quantitative modeling Tanja Kero, Department of Surgical

Tracer transport in human arteries affects MRI-based

Quantitative first-pass magnetic resonance imaging (MRI) is a promising technique to directly measure tissue perfusion parameters such as myocardial blood flow (MBF) or cerebral blood flow (CBF) [2,3]. Precise quantification requires, however, accurate knowledge of the arterial input function (AIF), i.e.


Tracer kinetic analysis of (S)-18F-THK5117 as a PET tracer for assessing tau pathology. Journal of nuclear medicine : official publication, So-ciety of Nuclear Medicine , 2016 , ( ): Reference tissue normalization in longitudinal (18)F-florbetapir positron emission tomography of late mild cognitive impairment.

Absolute Myocardial Blood Flow and Flow Reserve Assessed by

Jun 29, 2016 De Grado et al. was used for tracer kinetic modelling inferring a myocardium tissue density of 1.04 g/ml (14,15). Global MBF values were determined after fitting the tissue activity curves of the myocardial as well as right ventricular and left ventricular values (16). No specific correction


Tracer Kinetic Modeling in Myocardial Perfusion Quantification Using MRI, Felix Schwab, Michael Ingrisch, Roy Marcus, Fabian Bamberg, Kristof Hildebrandt, Christine Adrion, Christopher Gliemi, Konstantin Nikolaou, Maximilian Reiser, and Daniel Theisen 1206 Published online 31 March 2014 CONTENTS

Translation of Myocardial Metabolic Imaging Concepts into the

Myocardial Metabolic Imaging Concepts into the Clinics AdilBashir,PhDa,Robert J.Gropler, MDa ,b* Flexibility in myocardial substrate metabolism for energy production is fundamental to cardiac health. This loss in plasticity or flexibility leads to an overdependence on the metabolism of an indi-vidual category of substrates, with the predomi-

Imaging Left Ventricular Muscarinic Receptor Heterogeneity

directly to the regional heterogeneity of myocardial perfusion and sympathetic and parasympathetic function. As noted by Mazzadi et al,1 heterogeneity appears to play a major role in the arrhythmias associated with myocardial infarction and ischemia and probably some of the nonischemic cardiomy-opathies. Our own observation, using positron emission

Estimation of dynamic time activity curves from dynamic

Quantification of flow using SPECT requires dynamic data acquisition and tracers, such as 99m Tc-teboroxime, that accumulate in the myocardium in proportion to flow, and wash out rapidly, allowing potential measurement of coronary flow reserve (CFR) with dynamic SPECT

Anatomy-assisted direct parametric PET imaging for myocardial

myocardial blood flow abnormality detection Wei Deng, Xinhui Wang, Student Member, IEEE, Bao Yang, and Jing Tang, Senior Member, IEEE Abstract Dynamic myocardial perfusion (MP) PET imaging followed by tracer kinetic modeling provides quantitative measurement of myocardial blood flow (MBF). The purpose of

Using contrast agents to obtain maps of regional perfusion

Tracer kinetic modeling for quantification of perfusion and capillary wall permeability is a well-established approach, applied to various imaging modalities. In this review, methods employing intravascular as well as diffusible nonradioactive contrast agents for characterization of tissue microcirculation and

The effect of high count rates on cardiac perfusion

quantification of perfusion was then performed using a standard cardiac kinetic model. The decaying-source experiment showed a maximum noise equivalent count rate (NECR max) of 286 kcps at a singles rate of 47.1 Mcps. NECR was maintained within 5% (NECR 95%)oftheNECR max with a singles rate of 34.1 Mcps, corresponding to 310 MBq in the phantom.

Imalytics Research - Philips

cardiology (myocardial perfusion, absolute blood flow, coronary flow reserve, viability) biodistribution studies of new drug candidates (Voxulus) dosimetry in targeted radio-iodine therapy, SIRT, radio-peptide therapy, antibody therapy dementia evaluation with FDG or amyloid tracer (CAD4D) serial analysis (MultiViewer)

Proc. Intl. Soc. Mag. Reson. Med 9 (2001) 252 - ISMRM

diffusion across the myocardial capillaries with MR imaging. J Magn Reson Imaging 1994;4:433-40. 3. Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O. Myocardial perfusion modeling using MRI. Magn Reson Med 1996;35:716-26. 4. Vallee JP, Sostman HD, MacFall JR, et al. Quantification of myocardial perfusion by MRI after

Proceedings, 5th IFAC Symposium on Modelling and Control in

Quantification of 5-[123I]IODO-A-85380 in Nonhuman Primates Using SPECT: Parameter Identifiability and Stability 185 K.-P. WONG, S. EBERL, D.D. FENG, M. KASSIOU, M. J. FULHAM Prediction and Measurement of Electrical Impedance for Human Leg Segment 191 M. KHAN, IBREHEEM

Reconstruction of free-breathing myocardial perfusion MRI

INTRODUCTION: Respiratory motion of the heart represents a major practical problem in myocardial perfusion MRI. Firstly, the tracer kinetic models used for quantifying perfusion require that the myocardium remains stationary throughout the image time series, thus mandating a prior registration of the images.

Influence of contrast agent dispersion on bolus‐based MRI

most clinical perfusion MRI measurements are qualitative or semiquantitative (such as using the upslope technique), there is an increased interest in quantitative perfusion in terms of MBF in milliliters of blood per minute per gram of tissue or MPR. Tracer-kinetic models such as the Fermi-model9


Myocardial Infarction and Beyond, Haosen Zhang, Qing Ye, Jie Zheng, Erik B. Schelbert, T. Kevin Hitchens, and Chien Ho 737 Published online 18 October 2013 Notes Improved Quantification of Myocardial Blood Flow Using Highly Constrained Back Projection Reconstruction, David Chen, Behzad Sharif,

Diagnostic performance of semi-quantitative and quantitative

tracer kinetic models were used for quantitative analysis, the Fermi model was selected. When both a semi-quantitative and a quantitative outcome, or both 1.5 Tas well as 3.0 T were used, both outcomes were taken into account for the analysis. The primary data synthesis was based on bivariate mixed-effects binary regression modeling. Sensitivity,

Outline Modeling Approaches to Cardiac Perfu sion D etemr

A Rapid Dual-injection Method for Quantification of Rest and Stress Myocardial Blood Flow using 13N-Ammonia PET TC Rust; EVR DiBella; CJ McGann; PE Christian; JM Hoffman; DJ Kadrmas. Submitted to Soc Nucl Med 2006. Utah Center for Advanced Imaging Research (UCAIR) University of Utah Cardiac MRI Myocardial Perfusion MRI 0 10 20 30 40 50 60 70 80

Complete list of publications

Functional magnetic resonance imaging of the normal and abnormal visual system in early life. Neuropediatrics. 2000; 31(1): 24-32. 54. Andersen IK, Sidaros K, Gesmar H, Rostrup E, Larsson HB. A model system for perfusion quantification using FAIR. Magn Reson Imaging. 2000; 18(5): 565-574. 55. Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson

Multiparametric PET and MRI of myocardial damage after

quantification of tracer uptake can be challenging. Furthermore, data on αvβ3 imaging after myocardial in-farction using PET is limited, and in particular little is known about the relationship of myocardial blood flow and αvβ3 expression in this scenario. Thus, the purpose of this study was to evaluate the feasi-

ISMRM-ESMRBM Joint Annual Meeting 2014 Fashioning MR to

ISBN: 978-1-63439-764-3 ISMRM-ESMRBM Joint Annual Meeting 2014 Fashioning MR to Improve Global Healthcare Milan, Italy 10-16 May 2014 Table of Contents and Author Index

Molecular Imaging Rsna 2016 -

plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging.

Quantitative tumor perfusion imaging with 82Rubidium-PET/CT

Jan 24, 2019 using kinetic modeling and semi-quantitative measurements using standard uptake values (SUV) in late uptake images. 82 Rb is generator produced and is widely used for myocardial blood flow quantification in high throughput clinical settings.

Index []

adenosine perfusion MRI, 306 tracer kinetic model, 18 19 quantification and modeling, 39 41 readout methods, 49, 50 vs. BOLD, 108