Organ Preservation In Rectal Cancer

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Total Neoadjuvant Therapy for Rectal Cancer: An Emerging Option

for rectal cancer can alsofacilitate the selection ofpatients who may benefit from organ preservation, or a watch-and-wait approach,for their cancer. In this context, NAC added to neoadjuvant CRT might help further identify patients for whom surgical resection can be safely omit-ted.27 This would include increasing rates of tumor re-

Organ Preservation Among Patients With Clinically Node

CONCLUSIONS: Patients with rectal cancer with node-positive cancer at baseline who develop a complete clinical response after neoadjuvant chemoradiation are not at increased risk for local tumor regrowth or development of more advanced disease at the time of recurrence. These patients seem to be safe candidates for organ-preserving

Against the motion: This house believes multiparametric MRI

the holy grail for organ preservation in rectal cancer Against the motion. The low specificity means residual tumor while MRI predicted a pCR.

Organ preservation in rectal cancer: current status and

187 Organ preservation in rectal cancer: current status & future perspectives reVIew future science group shown to play an important part. Indeed, when

Role of magnetic resonance imaging in organ-preserving

organ-preserving strategies for the management of patients with rectal cancer Cinthia D. Ortega1*† and Rodrigo O. Perez2,3,4† Abstract Total mesorectal excision has been the most effective treatment strategy adopted to reduce local recurrence rates among patients with rectal cancer.

Total neoadjuvant therapy in locally advanced rectal cancer

chemotherapy prior to surgery serves as a strategy for organ preservation in the management of rectal cancer. Herein, currently available literature on different meth ‐ ods and strategies of the multimodal approach is critically appraised. KEYWORDS chemoradiation, chemotherapy, neoadjuvant therapy, organ preservation, rectal cancer


Organ preservation for rectal cancer Author: Eric Rullier Created Date: 7/9/2018 1:56:03 PM

Mesorectal radiotherapy for early stage rectal cancer: A

Organ Preservation abstract With the introduction of population-based bowel cancer screening, rectal cancer is diagnosed at earlier stages, yet standard treatment still requires the same extensive surgery that is used for more advanced stages. Organ preserving treatment is rapidly developing and is subject of investigation in numerous clin-ical

CURReNt tOpIC / АКТУЕЛНА ТЕМА Road to organ preservation in

Road to organ preservation in locally advanced rectal cancer Milica Nestorović1, Goran Stanojević 1,2, Branko Branković 1Clinical Center of Niš, Clinic for General Surgery, Niš, Serbia; 2University of Niš, Faculty of Medicine, Niš, Serbia SUMMARY Introduction In the past 20 years there has been significant change in the treatment of

10.45 Early Rectal Cancer Staging(share)

Only 15% underwent organ preservation by TEM/local excision/TAMIS 2017 accrual rates from 9 centres of 4 patients per month. A further 5 new sites for PRESERVE. 23 Exact test for single proportion, 2-sided test endpoint 10% improvement 20% improvement 25% improvement Test significance, alpha 0.05 0.05 0.05


8 cycles of chemotherapy result s in cCR , to per mit an organ preservation strategy for patients with stage I-IIIB (cT1-3, N0-2, M0) rectal cancer. We do not anticipate being able to prove this in the present single arm pilot study; that would be the principal objective of a successor, multi -institution phase II/III protocol.


What is the Phase II Study of Organ Preservation in Early Rectal Cancer Patients? It is a clinical trial to test if chemotherapy followed by local surgery and then chemotherapy and radiation therapy given have early stage, low risk rectal cancer. This would be instead of a major surgery that would lead to a colostomy.

Selection of Patients for Organ Preservation After

MR, et al. Organ preservation in rectal adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemother-apy, and total mesorectal excision or nonoperative management. BMC Cancer. 2015;15:767. 9.

Organ preservation in rectal cancer patients following

Organ preservation in rectal cancer following a complete clini - cal response to neoadjuvant CRT can be possible in a select group of patients. These patients should be followed up close - ly during the observation period. Clearly, prospective random - Figure 1. ERUS of the first patient, staged cT2N+ ERUS: endorectal ultrasound Figure 3.

STUDY PROTOCOL Open Access Organ Preservation in Rectal

Organ Preservation in Rectal Adenocarcinoma: a phase II randomized controlled trial evaluating 3-year disease-free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy, and total mesorectal excision or nonoperative management

Organ preservation in rectal cancer - ESCRS

High chance of organ preservation Beneficial for the good responders Cause of death: rectal cancer 33% 0 5 0 5 0 880 785 609 445 Number at risk 0 1 2 3

Watch-and-Wait as a Therapeutic Strategy in Rectal Cancer

cept in rectal cancer management and indicated the potential for organ preservation. Since then, the results have been up-dated, the treatment schedule has changed and many cancer centres are now sharing their own results and helping to build the evidence. Despite this, still many aspects of the W&W approach are undefined or controversial.

Can clinical factors be used as a selection tool for an organ

To solve the dilemma of treating rectal cancer either with upfront surgery or with CRT with the aim to omit invasive surgery, accurate patient selection is important. It would be practical if pretreatment clinical variables predicted which patients respond well to the preoperative CRT and might be candidates for organ preservation.

MRI and diffusion-weighted MRI to diagnose a local tumour

follow-up of organ preservation treatment after chemoradio-therapy for rectal cancer. Methods Seventy-two patients underwent organ preservation treatment (chemoradiotherapy + transanal endoscopic micro-surgery or Bwait-and-see^) and were followed with MRI in-cludingDWI(1.5T)every3-monthsduringthefirstyearand 6 months during following years.

Adjuvant radiotherapy after local excision of rectal cancer

of rectal cancer and a discussion of current practice. Results: We first considered local excision as a treatment option for early rectal cancer, looking at technical developments and the risks and benefits of organ preservation, in particular, the advantages

Locally advanced rectal adenocarcinoma: Treatment sequences

N1-N2) rectal adenocarcinoma (Table 1).1-7 Contemporary prospective trials are studying the main patterns of disease recurrence, long-term mortal-ity, and distant metastasis (DM) as well as realigning the balance between cure and quality of life. To this end, rectal organ preservation (WW) is a promising and in-

Biomarker-based treatment selection in early-stage rectal

Original article Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation K.J.Leong,A.Beggs,J.James,D.G.Morton,G.M.MatthewsandS

Fadwa G. Ali, M.D. - UC Davis

including colorectal cancer, inflammatory bowel disease, diverticulitis and anorectal problems. Dr. Ali has special training and interest in the management of colorectal malignancies. She is particularly passionate about minimally invasive colorectal surgery, and organ preservation approaches to the management of rectal cancer. Clinical Interests

Response to neoadjuvant chemoradiotherapy in rectal cancer is

Feb 01, 2020 Rectal cancer is a common malignancy (1), with approximately 11,000 case per year (10) or allowing potential organ preservation surgery (11) such

Where are we at with organ preservation for rectal cancer?

Early rectal cancer: the European Association for Endoscopic Surgery (EAES) clinical consensus conference Purpose of organ preservation is to reduce treatment

Neoadjuvant chemoradiotherapy for patients with - BMC Cancer

advanced rectal cancer (LARC), and is related to a survival benefit and organ preservation [6]. The pathogenesis of colon and rectal cancer is similar. Thus, NACRT is worthy of investigation in patients with unresectable LACC. Actually, several reports with a small sample size have evaluated NACRT followed by radical surgery for LACC [7]. We also

Local excision of scars after a complete clinical response to

preferred organ-preserving treatment strategy for patients with cCR after nCRT for patients with rectal cancer In fact, perhaps the most appropriate tool to assess functional outcomes among these patients would have been the low anterior resection syndrome score recently validated in multiple languages instead of the fecal incontinence scores

MRI cT1-2 Rectal Cancer Staging Accuracy: A Population Based

tunities for organ preservation, avoiding substantial morbidity and decreased function associated with radi-cal rectal resection4. However, correct patient selection with optimal staging is a prerequisite for a safe organ preservation strategy4. Superficial lesions (T1) without risk features and/or suspicious lymph nodes might be

Recent advances in (chemo-)radiation therapy for rectal

Rectal cancer represents approximately one-third of all colorectal cancer with the second highest incidence and the second highest cause of cancer death in the west-ern society [1]. Considering the restricted role of radio-therapy in the treatment of colon disease, we ll focus our review mostly on rectal cancer where radiotherapy has a

Transanal minimally invasive surgery for rectal cancer

organ preservation in selected cases. Transanal minimally invasive surgery (TAMIS) has evolved as an oncologically safe yet cost-effective platform for local excision of rectal tumors using traditional laparoscopic instruments. This review highlights the recent advances and current role of TAMIS in the treatment of rectal cancer. KEYWORDS


achieve organ preservation in patients with endorectal ultrasound (ERUS)- or endorectal coil magnetic resonance imaging (EC-MRI)-staged T2N0 rectal cancer located within 8 cm of the anal verge.

Organ preservation in rectal cancer: have all questions been

Organ preservation in rectal cancer: have all questions been answered? Corrie A M Marijnen Improved treatment strategies have eliminated local control as the major problem in rectal cancer. With increasing awareness of long-term toxic eff ects in survivors of rectal cancer, organ-preservation strategies are becoming more popular.

Long-Term Outcome of Rectal Cancer With Clinically (EUS/ MRI

ORIGINAL ARTICLE COLORECTAL CANCER Long-Term Outcome of Rectal Cancer With Clinically (EUS/ MRI) Metastatic Mesorectal Lymph Nodes Treated by Neoadjuvant Chemoradiation: Role of Organ Preservation Strategies in Relation to Pathologic Response Claudio Belluco, MD, PhD1, Marco Forlin, MD1, Matteo Olivieri, MD1, Renato Cannizzaro, MD2,

Dose escalation using contact X-ray brachytherapy (Papillon

which can improve the chance of organ preservation in patients who are not suitable for or refuse surgery. Cite this article as: Sun Myint A, Smith FMcL, Gollins SW, Wong H, Rao C, Whitmarsh K, et al. Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?.

Clinical response assessment after contact X-Ray

patients presenting rectal cancer treated with organ preservation intent using neoadjuvant treatment initiated with either CXB or EBCRT. Selection criteria for this strategy were: tumors, located in the distal or middle rectum, biopsy-proven adenocarcinoma, T2-T3 not exceeding 5 cm in largest dimension and/or half rectal

Organ Preservation in Rectal Cancer - UCSF CME

Organ Preservation in Rectal Cancer UCSF Annual Radiation Oncology Course, April 24, 2021 Mekhail Anwar Associate Professor, Radiation Oncology, UCSF [email protected] Outline Overview Treatment Paradigm Evaluation of Response Surveillance Outcomes Local recurrence Salvage Distant Recurrence

Press release -

May 11, 2021 organ preservation in patients with locally advanced rectal cancer with a good prognosis. In rectal cancer, where no standardized biomarker is available to personalize treatment, Immunoscore® is an independent parameter that is more informative than pre and post-neoadjuvant treatment imaging for - predicting disease-free survival. El Sissy et al.

Organ preservation for rectal cancer (GRECCAR 2): a

patients with rectal cancer tumour stage T2 and even T3, but with tumours of no more than 4 cm, are good candidates for organ preservation. By using a three-step strategy including clinical staging, clinical response, and pathological response, organ preservation could occur in 46% of patients without risk of missing positive mesorectal lymph

Organ preservation for rectal cancer

Organ preservation for rectal cancer GRECCAR trials Association between nodal and tumour response 644 patients: RT (n=450) or CRT (n=194) and TME