Coal Tar And Cutaneous Carcinogenesis In Industry

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Hieger isolated the carcinogen benzo[a]pyrene from coal tar pitch21. Boyland and Levi proposed in 1935 that toxic PAHs might either be intravitally converted into more active pathogenic substances or detoxified 75. Photo taken at The Cancer Hospital, London, May 9, 1934. From left to right, top row: Colin L. Hewett, Aaron Cohen, Geoffrey A. D.

Vol 3 Appendix M Health Risk Assessment - Alberta

smoke, and production of coal tar and coal tar products (ATSDR 1990). Emissions from residential wood combustion have been shown to contain more acenaphthylene than other PAHs (Perwack et al. 1982). Exposure A large database exists for the acute and chronic effects of PAH with most data available for benzo[a]pyrene.

I The Sir William Jackson Pope Memorial Lecture I I by III I

mineral oil or coal tar products (Anon., 1972). Another landmark in the history of chem-ical carcinogenesis was the recognition, in 1895, by the German physician L. Rehn, that cancer of the bladder was more common in workers at a dyestuffs factory than in the general population and his suggestion that these tumours had an occupational origin.

Occupational and Environmental Medicine (OEM) A BMJ journal

Coal Tar and Cutaneous Carcinogenesis in Industry. By Frank C. Combes. (Pp. 76; 25 illustrations. 20s.) Oxford: Blackwell Scientific Publications. 1954. Thisshort monographof60pagesprovides asummary of information relative to the problem of skin cancer. Greatest emphasis is placed upon cancer following exposure to various tars, and the medical

F. - P N Lee

from exposure to carcinogenic chemicals in industry arise relatively early in a mans working life. Men in their 20s or 30s may develop cancer the skin of the scrotum if exposed to soot, coal tar or carcinogenic mineral oils. Cancer of the urinary bladder tends to arise :15 - 20 years


isolated a single active carcinogen from coal tar, named as benzopryene, a polycyclic aromatic hydrocarbon (Smart 2004). Simultaneously, studies using animal models identified aromatic amines as carcinogenic, adding further data on the carcinogenic properties of industry chemicals (Luch 2005).

Carcinogenesis: Mechanisms and Manifestations

skin (pinna) to coal tars, rabbits developed squa-mous cell carcinomas, some of which metasta-sized. These findings in 1918 confirmed Percival Pott s strong epidemiological observations in 1775 of increased rates of cutaneous scrotal cancer in chimney sweeps and demonstrated that chronic exposures were necessary for the induction of some

Papers and Originals

brown coal Oral treatment of psoriasis Dyestuffs labourers Chimney-sweeps Various Mule spinners Henry would no doubt also be aware of the work of Yamagiwa and Ichikawa (1918), who had induced cutaneous carcinoma on the ear of the rabbit by painting with tar. This was the starting point of all experimental carcinogenesis.

Absorb/Absorption ACTH

Benzene: a carcinogenic compound widely used in the chemical industry; also found in tobacco smoke, vehicle emissions and gasoline fumes. Benzo(a)pyrene: a polycyclic aromatic hydrocarbon found in coal tar, automobile exhaust (especially diesel engines), wood smoke and charbroiled foods; causes

Review of Skin Permeation Hazard of Bitumen Fumes

limestone) and a binder (bitumen and, historically, tar or coal tarpitch);inNorthAmerica, asphalt refersonlytothebinder. The potential for health hazards arising from dermal exposure and possible uptake of bitumen fume or components is unclear. In 2001 the German MAK committee assigned a H-notation to bitumen fumes. However, the

GLOSSARY Absorb / Absorption

chemical industry; also found in tobacco smoke, vehicle emissions and gasoline fumes. Benzo(a)pyrene: a polycyclic aromatic hydrocarbon found in coal tar, automobile exhaust (especially diesel engines), wood smoke and charbroiled foods; causes changes in the chromosomes of a gene(s) (mutagenic) and is highly carcinogenic.

3. chapter 21. Analysis of tumour site concordance

Part 3 Chapter 21. Analysis of tumour site concordance 213 Table 21.1. Group 1 agents included in Volumes 100A F, 105, 106, 107, and 109 a Volume

Bad air gets under your skin - Wiley

gases. The majority of outdoor PAHs are derived from coal tar, die-sel exhausts and cigarette smoke.[5] In addition to inhalation, dermal exposure to PAHs represents an important route as they can be easily absorbed through the skin.[2] Numerous studies support the associa-tion between PAHs and adverse effects on skin health.