Orbital Lymphoma Treatment

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Original Article Long-Term Outcome in Localized Extranodal

organs. At the time of disease recurrence, 7 patients (23%) had transformed to diffuse large B-cell lymphoma, 2 of whom died of lymphoma. The 5-year OS rate after treatment failure was 83%. CONCLUSIONS: Patients with localized MALT lymphomas are reported to have excellent clinical outcome after moderate-dose RT, and some are likely cured.

Orbital MALT Lymphoma: A Case Report

disease process, radiation therapy is the primary modality of treatment. Treatment of orbital lymphoma with radiotherapy is challenging because of the radiosensitivity of the lens, lacrimal gland, and retina, which are located near or within the target volume. Field arrangements vary depending on the exact location of the disease.

Peer Reviewed, Open Access, Free Published Quarterly

treatment. Radiotherapy is a well-established treatment modality for orbital lymphoma Primary chemotherapy has minimal efficacy in localised low-grade orbital lymphoma and thus is not advocated as a first-line treatment.8 Differ-ent radiation techniques can be used depending on the ex-tent of involvement. For tumours limited to the eyelids, su-

Oculo-Orbital Non-Hodgkin s Lymphoma: A Retrospective Study

Background: Oculo-orbital non-Hodgkin lymphoma is a rare presentation of lymphoma. The objective of our study was to clarify the clinical features of non-Hodgkin's oculo-orbital malignant lymphoma and to establish the place of radiotherapy in the treatment.

IMRT for Orbital MALT Lymphoma: A Case Report and a Review of

B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) type ise the most common histological type involving the orbit [2,3]. For Stage I and II localized disease process, radiation therapy is the primary modality of treatment. Treatment of orbital lymphoma with radiotherapy is challenging because of the radiosensitive lens, lacrimal

Orbital Location of Non-Hodgkin's Lymphoma Type B: About A Case

Non-Hodgkin s lymphoma with orbital location is a relatively rare tumor and difficult diagnosis, orbital location accounts for 5 to 10% of orbital expansive processes [1] The confirmation of the diagnosis is made by histology and immun histochemistry, the treatment consists of poly chemotherapy with multidisciplinary care. Observation

Review Article Orbital lymphoma: Role of radiation

Orbital lymphoma refers to a lymphoma occurring in the conjunctiva, lacrimal gland, eyelid and ocular musculature. Primary non-Hodgkin™s lymphoma (NHL) of the orbit is a rare

Examining the utility of lower dose radiotherapy for

the International Lymphoma Radiation Oncology Group (ILROG),10 in 2015 published radiotherapy guidelines for the treatment of extranodal lymphomas and suggested that orbital lymphomas be treated with 24-25 Gy in 1.5-2 Gy fractions. Our experience is in line with these guidelines and the current study findings support the use

Orbital lymphoma: diagnostic approach and treatment outcome

MALT lymphoma was diagnosed in nine patients (82%), and the other two patients were diagnosed with diffuse large B-cell lymphoma and with recurrence of mantle cell lymphoma, respectively. Table 1 Patient and treatment characteristics of orbital lymphomas (n = 11) Characteristic Number of patients % Age (years) Median 57.7 Range 42.5 to 88.7

Treatment of Benign Lymphoid Hyperplasia of the Orbit With

lymphoma and rheumatoid artltitis. We report successful treat-ment of 2 patients with bellign lymphoid hlperplasia of the orbit with rituximab. CASE REPORTS Case 1. A 4l-year-old wonan wirh a history ofbenign lymphoid hyperplasia ofthe right orbit was evaluated by our orbital oncol-ogy service after the onset ofperiorbital swelling. ptosis

Outcome of primary orbital lymphoma treated with induction

Primary orbital lymphoma (POL) is an uncommon extra nodal lymphoma, accounting for 8% of all extra nodal NHL and 1% of all NHL [1,2]. It makes up 10% of all orbital tumors [3]. Maltoma has been reported to be the commonest type of NHL in POL. However, diffuse large B cell lymphoma (DLBCL) and marginal zone lymphoma (MZL) have also

Orbital lymphoma in a developing community

10. Eckardt AM, Lemound J, Rana M, Gellrich NC. Orbital lymphoma: Diagnostic approach and treatment outcome. World J Surg Oncol. 2013;11:73. doi: 10.1186/1477-7819-11-73 11. Mallick S, Das S, Benson R, Vikas Roshan, Suman Bhasker. Outcome of primary orbital lymphoma treated with induction chemotherapy followed by conformal radiotherapy.

Subconjunctival Orbital Fat Prolapse: Diagnosis and Management

dangerous orbital pathologies can mimic subconjunctival orbital fat prolapse. The excised orbital fat needs to be evaluated histopathologically to rule-out any malignancy. Surgical repair is straight-forward and cosmetically satisfying to patients. Case Report: A 79-year-old male presented with subconjunctival orbital fat prolapse.

Differentiation of orbital lymphoma and idiopathic orbital

Orbital lymphoma and idiopathic orbital inflammatory pseudotumor (IOIP) represent the most common lympho-proliferative disorders affecting the orbit [ 1], accounting nearly 20% of all orbital mass lesions [1 3]. Most orbital lymphomas are low-grade neoplastic lesions, and the most frequently observed subtype is mucosa-associated lymph-

Orbital inflammatory disease management

idiopathic orbital inflammation treatment; orbital myositis; Castleman s disease orbit treatment 1. Introduction Orbital inflammatory disease (OID) represents an etiologically diverse spectrum of conditions unified in their association with abnormal inflammation in the periorbital region. These condi-tions can be roughly grouped into two

Times Not to Forget Radiotherapy When Treating Patients With

Apr 10, 2019 or other orbital retrobulbar structures is possible. Marginal zone lymphoma is the most common histology, although DLBCL and follicular lymphoma have also been described. Bilateral involvement occurs in a minority of presentations. These conjunctival and orbital presentations are managed differently from intraocular lymphoma. The most common

Partial orbit irradiation achieves excellent outcomes for

Treatment We have previously reported our institutional tech-niquesfor treating lymphoma involvingthe conjunctiva,15 and other orbital sites.7,16,17 Partial orbital treatment of conjunctival lesions was performed using a clinical setup. An anterior electron field was used in conjunction with a small diameter lens shield placed anterior to the lens.

Non-Hodgkin s lymphoma with orbital, oral and systemic

study of 11 patients with orbital tumors, 9 patients (82%) were diagnosed with extranodal MALT Lymphoma and 2 patients with Diffuse Large B cell Lymphoma and recurrent Mantle Cell Lymphoma respectively.3 Extra nodal sites of involvement of Non-Hodgkin s Lymphoma are GIT, bone, skin and Waldeyer s ring. Intraoral sites like gingiva, buccal

Orbital T-cell lymphoma in youngest recorded patient early

Orbital and ocular adnexal lymphoid neoplasms are not scarce, representing 6 to 8% of all orbital tumors, whereas out of the extranodal non-Hodgkin s lymph-omas, primary non-Hodgkin s lymphoma of the orbit represented 8 to 10% [8, 9]. Based on case series, the most reported orbital lymphoid tumor was B cell non Hodgkin malignant lymphoma

Orbital lymphoma in an elderly patient

Orbital lymphoma 1126 studies followed by early surgical biopsy will contribute to early diagnosis. Radiation therapy is an effective treatment for orbital lymphoma resulting in local control in the majority of cases. It is important to continue long term follow-up of these patients to assess for local control, complications, and

Mantle Cell Lymphoma in the Orbital and Adnexal Region

Mantle cell lymphoma in the orbital and adnexal region 6/16 RESULTS Clinical features and location of disease A total of 21 cases (9%) of MCL in the orbital and adnexal region were identified out of 230 Danish patients with lymphoma in the ocular region covering 25 years. These included 18 (86%) male- and

Case Report: Atypical Lymphoid Infiltrate of the Right Orbit

increased, however diagnostic features of lymphoma were not present. V. Treatment, management o Management: o Referral to oculoplastics and oncology for biopsy and full staging work up o CT, MRI, bone marrow aspiration, and biopsy required to distinguish classification of orbital mass and treatment approach. Options include excision

CLINICAL SCIENCES CyberKnife Radiosurgery for the Treatment

CyberKnife radiosurgery for the treatment of orbital lymphoma in a 79-year-old woman. A, Orbital lymphoma. B, Lymphoma shown on magnetic resonance imaging. C, Treatment with CyberKnife. Excellent clinical (D) and imaging (E) response, demonstrating marked resolution of the orbital tumor. A C B D E Figure 2.

Diagnosis and Management of Orbital Lymphoma

Treatment and Prognosis There are four main treatment op-tions for orbital lymphoma: surgery, radiotherapy, chemotherapy, and im-munotherapy. Prognosis depends upon the histology, grade and stage (see Grading and Staging ), and treatment modality employed, but the overall five-year survival rate is approximately 60 percent. Surgery

Ocular, Orbital and Periorbital Neoplastic Conditions of the

(lacrimal gland adenocarcinoma) or lymphatic tissue (lymphoma or lymphosarcoma), extra-adrenal paraganglioma (Miesner et al., 2009), hemangiosarcoma, melanoma and orbital extension of tumours from the eye, eyelids or conjunctiva (usually either carcinoma or lymphoma) and extensions

Orbital Lymphoma: Results of Radiation Therapy

Orbital lymphoma is a rare presentation of non-Hodgkin s lymphoma. Treatment with radiotherapy is well-established. Twenty cases of orbital lymphoma treated at the Singapore General Hospital with radiation therapy were reviewed. All patients had impr ovement of their initial presenting symptoms and complete remission after radiation.

Orbital Lymphoma-An International Multicenter Retrospective Study

TABLE 1. Eye Cancer Center Distribution of Patients by Subtype of Orbital Lymphoma Eye Cancer Center CPH LIV HOU HYD NY ATL MEL Subtype, N (%) 256 (32) 94 (12) 188 (24) 159 (20) 29 (4) 14 (2) 57 (7)

ARROCase Orbital MALT

Orbital/Ocular Adnexal Lymphoma Lymphomas are the most frequent tumor of the ocular adnexa. Ocular Lymphomas: 1) Marginal Zone Lymphoma of MALT (~40-80%) 2) Follicular Lymphoma (~20%) 3) Diffuse Large B-Cell Lymphoma (~8%) 4) Mantle cell, small lymphocytic, lymphoplasmacytic (these are less common)

Prevalence and Nature of Systemic Involvement and Stage at

Treatment in Patients With Orbital and Ocular Adnexal Lymphoma Treatment No. of Patients External beam orbital radiotherapy 8 Systemic chemotherapy 1 Ibritumomab

Ptosis as an Initial Manifestation of Orbital Lymphoma: A

orbital lymphoma [1]. Orbital lymphoma usually presents with proptosis, periorbital swelling, conjunctival ( salmon-pink ) swelling, diplopia, and conjunctival redness and irritation [2 6]. It can remain indolent for a long period of time before the patient notices the periorbital abnormality [2 6].

Recurrence patterns of mucose-associated lymphoid tissue

of patients. For orbital adnexal MALT lymphoma patients, routine Chlamydia psittaci examination has been performed since 2009. Treatment RTwas delivered as afirst curative treatment in all 134 patients. In some cases, combined chemotherapy was used at the discretion of the treating physician, usually due to bulky tumor or tumor aggressiveness.

Orbital lymphomas missed by first biopsies of orbital masses

Orbital lymphoma can mimic inflammatory orbital disease and other diseases in clinical presentation and imaging (Polito et al. 1996; Gordon 2006; Igarashi et al. 2013; Hwang et al. 2014). In present report, a secondary biopsy was necessary in each case because of either recurring symptoms during treatment, or clinical presenta-

Orbital Lymphoma: Clinical Profile, at a tertiary care

Fig. 1-3: Clockwise- Unilateral Orbital Lymphoma, Bilateral Orbital Lymphoma, Salmon Patch Fig. 3-5: From Left to right.-Pre-treatment state, CT scan Findings and Post treatment state of an Orbital Lymphoma Patients Table 1: Patients profile of Orbital Lymphoma Variables Number Percentage Total patients Yes123 Male: Female 85:38 2.23: 1 Age

Case Report Orbital Lymphoma Masquerading as Orbital Cellulitis

out metastasis. Regarding the treatment of localized orbital lymphoma, radiotherapy is appropriate for local control [18, 19]. For metastatic or systemic spread, chemotherapy or a combination of chemotherapy and radiotherapy is highly effective [20]. The prognosis of orbital lymphoma depends upon the various subtypes of lymphoma, as MALT

Orbital Neoplasms in Adults: Clinical, Radiologic, and

adult orbital tumor. They typically appear as a well-circumscribed, ovoid intraconal mass on cross-sectional images. Lymphoma, which may be pri-mary or secondary to systemic disease, is the most prevalent orbital neo-plasm in older adults (≥60 years of age). Choroidal melanoma is the most common primary adult ocular malignancy.

Radiosugery with CyberKnife in Primary Orbital MALT Lymphoma

12. Olga, Ésik. A Retrospective Analysis of Different Modalities for Treatment of Primary Orbital Non-Hodgkin's Lymphomas. Radiother Oncol 38 (1996): 13. 13. Piero, Galieni. Localized Orbital Lymphoma. Haematol 82 (1997): 436-439. 14. Melanie C. Smitt and Sarah S. Donaldson. Radiotherapy is Successful Treatment for Orbital


Treatment depends on the stage: in localized orbital lymphoma, radiotherapy is highly effective, while in patients with high grade histology or disseminated lymphoma, systemic chemotherapy should be used. In some localized cases, antibiotic therapy against Chlamydia results in complete remission [12,13]. Case report

Treatment volume definition for irradiation of primary

Conclusion: Accurate and precise target and treatment volume determination comprises an indispensable aspect of successful orbital lymphoma irradiation. Within Within this context, incorporation of MRI in target and treatment volume defi nition process may be strongly considered for improving the optimization of target and treatment

A clinicopathologic study of orbital and adnexal nonâ Hodgkin

cytic lymphoma, and 2 patients with diffuse histiocytic lymphoma. It was con- cluded that the Rappaport classification is applicable to orbital lymphoid tumors and that those lymphomas which do present as primary tumors should be staged as one would stage the same histologic category of lymphoma pre- senting in other sites.

Orbital lymphoma: imaging features and differential diagnosis

Otherwise, aggressive subtype lymphoma or advanced stage (II, III or IV of Ann Arbor Criteria) combined with chemotherapy [10]. Radiological findings were reviewed regarding treatment response related to the Table 1 Histological subtypes of orbital lymphoma Lymphoma subtypes Number of patients Extra-nodal marginal zone lymphoma (MALT) 16