Absence Of A Natural Inhibitor Of The TRNA Methylases From Fetal And Tumor Tissues

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Absence of a Natural Inhibitor of the tRNA Methylases from

Absence of a Natural Inhibitor of the tRN from Fetal and Tumor Tissues SYLVIA J. KERR Department of Microbiology, University of Colorado Medical Center, Der Communicated by Theodore T. Puck, November 10, 1970 ABSTRACT The inhibitor of tRNA methylases of nor-mal adult tissues has been resolved into two fractions,

Absence Natural Inhibitor tRNA Methylases fromFetal Tumor

Normal adult tissues contain inhibitors of the enzymes that methylate tRNA (1). I report here on the purification and separation of the inhibitor from normal tissue into two frac-tions, a high molecular weight protein and a low molecular weight component. Neither of the components alone inhibits the tRNA methylases, but in concert they restore