Insights Into The Role Of Sialylation In Cancer Progression And Metastasis
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Cancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal
While sialylation and fucosylation have predominated the focus of cancer-associated glycan modifications, the emergence of blood group I antigens (or I-branched glycans) as key cell surface moieties capable of modulating cancer virulence has reenergized investigations into the role of the glycome in malignant progression. I-branched
A strategy to reveal potential glycan markers from serum
The N-glycan pool from advanced breast cancer serum N-Linked glycans from total serum glycoproteins of 18 ad-vanced breast cancer patients with metastasis (stage 4) and 18 cancer-free controls were analyzed by normal phase (NP)- and weak anion exchange (WAX)-HPLC in combination with se-quential digestion using an array of exoglycosidases and MS.
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Glycosylation alterations are frequently found in cancer and specific glycan structures are a hallmark of cancer development and progression . The characterization of glycosylation modifications occurring in cancer is of high interest and represents a source of putative new biomarkers for cancer detection,
Sialylation and fucosylation of epidermal growth factor
tant cell cell interactions andcell migrations in cancer metastasis and angiogenesis (2). However, little evidence has been shown to support the causative roles of sialylation and fucosylation in malignant transformation. Because sialylation and fucosylation occur globally, their exact roles in the growth and metastatic be-
The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal
sialylation and activating JAK2/STAT3 pathway. Our study presents novel insights into CRC progression and provided prospective therapeutic target for CRC. Keywords: HOTAIR, MiR-214, ST6GAL1, c-Met, JAK2/STAT3 cascade Background CRC is the third most common cancers, with a major burden of nearly 700,000 deaths each year worldwide .
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tumor growth, escape from apoptosis, metastasis formation, and resistance to therapy. Collectively, these novel insights provide further rationale for the design and development of therapeutic approaches that interfere with excessively high expression of sialic acids in cancer cells. Strategies to target aberrant sialylation in cancer,
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escape from apoptosis, metastasis formation, and resistance to therapy. Collectively, these novel insights provide further rationale for the design and development of therapeutic approaches that interfere with excessively high expression of sialic acids in cancer cells (Figure 2). Strategies to target aberrant sialylation in cancer,
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cause of any individual breast cancer case is typically unknown. As many studies have suggested, changes in gene expression levels for breast cancer may not fully reflect the true state of cancer progression or development.5,8,9 This conclusion suggests that many of the differences between normal and cancer tissue may be caused by PTMs.1,3,5,6
Sialylation and fucosylation of epidermal growth factor
tant cell-cell interactions and cell migrations in cancer metastasis and angiogenesis (2). However, little evidence has been shown to support the causative roles of sialylation and fucosylation in malignant transformation. Because sialylation and fucosylation occur globally, their exact roles in the growth and metastatic be
Review Article Our Studies on Aberrant Glycosylation in Oral
Progression of cancer is a multi-step process and involves sequential changes during neoplastic transformation. Aberrant glycosylation, a hallmark of cancer, aids in cancer cell survival, proliferation and metastasis, thus playing an important role in tumorigenesis. The present review describes our results on