Insights Into The Role Of Sialylation In Cancer Progression And Metastasis

Below is result for Insights Into The Role Of Sialylation In Cancer Progression And Metastasis in PDF format. You can download or read online all document for free, but please respect copyrighted ebooks. This site does not host PDF files, all document are the property of their respective owners.

When citing, please refer to the published version.

Cancer-associated glycan structures can be both tumor markers and engines of disease progression. The structure Siaα2,6Galβ1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan. Although ST6GAL1/Sia6LacNAc are often overexpressed in colorectal

I-branchedcarbohydratesasemergingeffectorsof PERSPECTIVE

While sialylation and fucosylation have predominated the focus of cancer-associated glycan modifications, the emergence of blood group I antigens (or I-branched glycans) as key cell surface moieties capable of modulating cancer virulence has reenergized investigations into the role of the glycome in malignant progression. I-branched

A strategy to reveal potential glycan markers from serum

The N-glycan pool from advanced breast cancer serum N-Linked glycans from total serum glycoproteins of 18 ad-vanced breast cancer patients with metastasis (stage 4) and 18 cancer-free controls were analyzed by normal phase (NP)- and weak anion exchange (WAX)-HPLC in combination with se-quential digestion using an array of exoglycosidases and MS.

Cellular prostatic acid phosphatase: a protein tyrosine

cancer, especially those with bone metastasis, com-pared with healthy adults (Gutman et al. 1936). Subsequently, it was established that the PAcP activity in the circulation of prostate cancer patients correlates with prostate cancer progression and could serve as an Endocrine-Related Cancer (2005) 12 805 822

Melanoma Cell Galectin-1 Ligands Functionally Correlate with

provide important insights into the development of anticancer therapeutics and lay the foundation for generation of reliable diagnostic markers for tumor growth and metastasis. Malignant melanoma is a well-documented tumor model leveraging Gal-1/Gal-1 ligand interactions. Complete ablation of melanoma- and host-derived Gal-1 expression severely

Mass Spectrometry-Based N-Glycomics of Colorectal Cancer

Dec 09, 2015 Abstract: Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. An increased molecular understanding of the CRC pathology is warranted to gain insights into the underlying molecular and cellular mechanisms of the disease. Altered protein glycosylation patterns are associated with most diseases including malignant transformation.

PROTEOMICS Reviews 2014

by recent reports that suggest the deep involvement of cancer cell-derived EVs in metastasis. In their review, Takeshi Katsuda and colleagues summarize recent studies of EVs in cancer biology and highlight the possibility of developing novel diagnostic technologies exploiting circulating EVs.

SECOND WORKSHOP - GLYCOVAX

Glycosylation alterations are frequently found in cancer and specific glycan structures are a hallmark of cancer development and progression [1]. The characterization of glycosylation modifications occurring in cancer is of high interest and represents a source of putative new biomarkers for cancer detection,

Sialylation and fucosylation of epidermal growth factor

tant cell cell interactions andcell migrations in cancer metastasis and angiogenesis (2). However, little evidence has been shown to support the causative roles of sialylation and fucosylation in malignant transformation. Because sialylation and fucosylation occur globally, their exact roles in the growth and metastatic be-

The HOTAIR/miR-214/ST6GAL1 crosstalk modulates colorectal

sialylation and activating JAK2/STAT3 pathway. Our study presents novel insights into CRC progression and provided prospective therapeutic target for CRC. Keywords: HOTAIR, MiR-214, ST6GAL1, c-Met, JAK2/STAT3 cascade Background CRC is the third most common cancers, with a major burden of nearly 700,000 deaths each year worldwide [1].

Microgravity and Cell Adherence - MDPI

Mar 23, 2020 Overall, this Special Issue provides new data and novel insights into the complexity of cell adherence and its alteration upon omitting gravity. Knowledge is provided about the causes and consequences of microgravity-caused reduction in cell adhesion strength and their relationships to tumor growth and metastasis as well as to wound healing.

UNIVERSITÀ DEGLI STUDI DI PARMA Dottorato di ricerca in

protein sialylation, which was analyzed in a specific type of cells in this work, was found to be involved in cancer metastasis. Furthermore, typical enrichment methods such as HILIC (used in our glycoproteomics experiments) were reviewed. MS is a challenge in glycoproteomics due to the

Label-free Quantitative Proteomics and N-Glycoproteomics

that may provide insights into KRAS-induced adenocarci-noma and have implications for both lung cancer therapy and diagnosis. Molecular & Cellular Proteomics 11: 10.1074/mcp.M112.020875, 901 915, 2012. Lung cancer is the leading cause of cancer deaths world-wide in males and the second in females (1). Adenocarcinoma

UDP-Glucose 6-Dehydrogenase Knockout Impairs Migration and

May 30, 2020 biosynthesis is critical for metastasis in a mouse model of breast cancer. INTRODUCTION Breast cancer remains the most common cancer in women worldwide and is the leading cause of cancer deaths in women [1]. The vast majority of breast cancer-related deaths occur due to metastasis, which is currently considered incurable [2].

Sialic Acids Sweeten a Tumor's Life - Cancer Research

tumor growth, escape from apoptosis, metastasis formation, and resistance to therapy. Collectively, these novel insights provide further rationale for the design and development of therapeutic approaches that interfere with excessively high expression of sialic acids in cancer cells. Strategies to target aberrant sialylation in cancer,

ANNUAL MEETING PROGRAMME Friday 14th October 2016

6Centre for Cancer Research and Cell Biolog, Queen's University Belfast, Belfast, UK 15.50-16.05 NOVEL INSIGHTS INTO THE CLINICAL PHENOTYPE AND PATHOPHYSIOLOGY UNDERLYING LOW VWF LEVELS: THE LOW VON WILLEBRAND FACTOR IRELAND COHORT (LOVIC) STUDY Michelle Lavin1,2,3, S Aguila2,3, S Schneppenheim4, N Dalton1,2, JM O'Sullivan2,3, NM

Sia: The Sugar Code of Life - Crimson Publishers

escape from apoptosis, metastasis formation, and resistance to therapy. Collectively, these novel insights provide further rationale for the design and development of therapeutic approaches that interfere with excessively high expression of sialic acids in cancer cells (Figure 2). Strategies to target aberrant sialylation in cancer,

Glycogene Expression Alterations Associated with Pancreatic

inhibitor sensitivity in pancreatic cancer cells that have lost epithelial-like traits [8]. Intensive investigations have uncovered many of the regulatory mechanisms and molecular characteristics of this conversion [2,6,7,8,9], but the in-vivo factors at work in cancer EMT and that are relevant to pancreatic cancer progression are not clear.

Mammary Gland in Development & Cancer

epithelial cells and cancer cells, which may protect the gland against bacterial infection, drive gland development and cancer dissemination. An Hendrix and Alistair Hume suggest that exosomes can transport and disseminate tumor lipids, proteins, RNA types and DNA material systemically, so their role in metastasis formation is hypothesized. In the

Protein Modifications as Potential Biomarkers in Breast Cancer

cause of any individual breast cancer case is typically unknown. As many studies have suggested, changes in gene expression levels for breast cancer may not fully reflect the true state of cancer progression or development.5,8,9 This conclusion suggests that many of the differences between normal and cancer tissue may be caused by PTMs.1,3,5,6

Sialylation and fucosylation of epidermal growth factor

tant cell-cell interactions and cell migrations in cancer metastasis and angiogenesis (2). However, little evidence has been shown to support the causative roles of sialylation and fucosylation in malignant transformation. Because sialylation and fucosylation occur globally, their exact roles in the growth and metastatic be

Review Article Our Studies on Aberrant Glycosylation in Oral

Progression of cancer is a multi-step process and involves sequential changes during neoplastic transformation. Aberrant glycosylation, a hallmark of cancer, aids in cancer cell survival, proliferation and metastasis, thus playing an important role in tumorigenesis. The present review describes our results on