Quality Of Life For Patients Following Total Laryngectomy Vs Chemoradiation For Laryngeal Preservation

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Tumor Volumes and Prognosis in Laryngeal Cancer

treatment, invasiveness, quality of life and voice quality, are considered when selecting the best therapy for early laryngeal cancers. 2.2. Advanced LC Locoregionally advanced (stage III/IV) squamous cell carcinoma of the larynx is associated with a high risk of both local recurrence and distant metastases [17]. Historically, total laryngectomy

Predicting quality of life in advanced hypopharyngeal and

Advanced hypopharyngeal and laryngeal cancers and their treatment significantly impair quality of life (QOL), whether organ-preservation treatment protocols are used or not (Hanna at al., 2004). Therefore, assessing QOL in these patients is of the utmost importance, and it is now a standard

Device Life of Two Generations of Provox Voice Prostheses

collected for patients receiving voice prosthesis replace-ment at the outpatient otolaryngology clinic at the Keck Medical Center of USC between January 1, 2008, and November 1, 2014. During this interval, 46 patients were evaluated for communication following total laryngectomy. Patients were excluded if they received only 1 initial device

Outcomes of total laryngectomy: how to improve?

surgery (total laryngectomy TL) and organ preservation therapies (chemoradiotherapy) remains controversial in the treatment of locally advanced tumors. In a time where improving survival goes along with better quality of life, limited toxicities and reduced costs, TL cannot be put aside, remaining a safe and effective treatment, with some long


patients, but now quality of life studies have become an important aspect in the treating clini-cian s decision making. There are few studies on the quality of life in patients using TEP.6,7 These have looked at the overall quality of life in laryng-ectomised individuals. Although it is essential to evaluate the overall quality of life in

One of the consequences of a total of life. This study

a first step to restoring an active life for laryngectomized patients. Recent studies showed that physical activity in patients with cancer improves quality of life, and increases overall and cancer-free survival. As part 1 of the project, 38 members of the German Society of Laryngeal Patients answered questions regarding their

Organ preservation in locally advanced larynx and hypopharynx

Results: A total of 62 (45%) of patients were upstaged. Upstaged patients had a longer median time to surgery compared to non-upstaged patients (81 vs 68 days, p=0.017) and 21% (n=13) were upstaged to T ≥ T3 or N ≥ N1. There was a trend to higher incidence of margin positivity in upstaged

Comparison of total laryngectomy with surgical

preservation rate was 45% for radiotherapy and 76.7% for CHP (p ¼.0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS ¼ 78% vs

Hypopharyngeal Cancer Chemoradiotherapy or Surgery, The

1990 s VA Trial, (Neoadjuvant Chemo/Rad or Laryngectomy) 2000 s Adoption of Organ Preservation Approaches. 1960 2013 100% TL Functional Larynx? 40% TL Quality of Life? I have seen the future and it doesn t work. Robert Fulford

LitAlet 2014 - 03 15 - Atos Medical Laryngectomy Care

laryngeal cancer amenable to total laryngectomy or a laryngeal preservation protocol. Questionnaires were filled in by 269 patients attending the otorhinolaryngology clinic. Results showed that 28.6% of patients would not consider any trade-off in cure to preserve their larynx; 1.4% of patients were willing to trade all chances of cure in order


REVIEW Comparison of quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy MARIA M. LOTEMPIO, MD, KEVIN H. WANG, BS


total laryngectomy group was longer (89.9 vs 27.7 months). The survival benefit afforded by total laryngectomy was even more striking in patients of lower N classification (N0 and N1). The authors suggest choosing total laryngectomy to treat T4a laryngeal cancer with thyroid cartilage invasion, especially in subjects exhibiting limited nodal

Complications of Laryngectomy

countries. 2 global laryngeal cancer cases (77,505/156,877) and deaths (44,639/83,376) occurred in Asia. 6 Squamous cell cancer of larynx significantly affects the quality of life and causes serious Complications after total laryngectomy can be disease burden to public health in the long run.& divided into local (fistula, infection, chyle leak,

Engleza nr 3-2011 - PANDORA2

is a legitimate option in patients with advanced hypopharyngeal cancer who desire to avoid a total laryngectomy. Another relevant issue regarding an organ preservation approach is whether concurrent chemoradiation therapy is better than induction chemotherapy followed by radiotherapy. This issue was examined for laryngeal cancer in

Calidad de vida y beneficio clínico con tratamiento - ISCIII

for patiens following total laryngectomy vs chemoradiation for laryngeal preservation. Arch otolaryngol Head Neck Surg. 2004 Jul; 130 (7): 875-9. 7. Bjordal K, Kaasa S, et al. Int J Radiat Oncolo Biol Phys. 1994 Mar 1; 28(4): 847-56. 8. Harwood AR, Rwlinson E. The quality of life of patient following treatment for laryngeal cancer. Int Radiat


gery patients to patients with successful organ preservation. During the workshop, conference participants and panelists were challenged with trying to an-swer two questions: is organ preservation with chemotherapy and radiation an accepted alterna-tive for laryngectomy for patients with stage III or IV laryngeal cancer; and should clinical trials

Chemoradiotherapy vs. total laryngectomy for primary

larynx preservation, the main endpoints of the RTOG 91-11 study were laryngectomy-free survival with laryngectomy or death from any cause.2,3 Secondly, proper selection of patients who are candidates for laryngeal preservation is crucial. Driven by the VA study results demonstrating significantly higher rate of salvage laryngectomies


Pharyngeal Closure with Endoscopic Stapler after Total Laryngectomy Chih-Kwang Sung, MD; Ramon A. Franco Jr., MD 44 3D Arytenoid Movement Induced by Vocal Fold Injections I-Fan Theodore Mau, MD, PhD; Kent Weinheimer, BS 44 Organ Preservation Surgery for Laryngeal Squamous Cell Carcinoma: Low Incidence of Thyroid Cartilage Invasion

Progressive resistive exercise training for shoulder function

Conclusion: The larynx preservation protocol achieves the same survival rates that total laryngectomy, contributing 50% of preservation of organ function. It is necessary more cases for a final evaluation. EP-1059 Structured assessment of radiation-induced fibrosis following treatment for head and neck cancer. G. Adigbli

Options for Preserving the Larynx in Patients with Advanced

greatly improved voice restoration rates following total laryngectomy, and most patients are able to speak in a hoarse but natural-sounding voice. Therefore, voicepres­ ervation is the least important quality-of-life consider­ ation in the decision-making process. Standard treatment considerations In discussing what is experimental and what

Considerations for the SLP along the Continuum of Care

LARYNGECTOMY 55 yofwith total laryngectomy (10/30/17) with myofascial/myocutaneous flapprocedure. Pt presented w/ remote hx of squamous cell carcinoma (no staging available) of the larynx (2002), warranting chemoradiation which resulted in laryngeal dysfunction and chronic aspiration. Since that time, pthas struggled

Quality of Life for Patients Following Total Laryngectomy vs

hand, chemoradiation patients reported significantly greater problems with dry mouth (P=.02). Conclusions: Both chemoradiation and TL affect, al-beit differently, the QOL of patients treated for ad-vanced cancer of the larynx. Although these differences can be detected by functional and subscale analysis, the

Douleurs sequellaires en ORL M Navez Centre de la Douleur St

quality of life outcomes in laryngeal cancer patients following chemoradiation vs. total laryngectomy. Otolaryngol Head Neck Surg. 2005 Jun;132(6):948-53.) 3.Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, Nalysnyk L, Zilberberg MD. Mucositis incidence, severity and associated outcomes in patients with head and