Developmental Toxicity Evaluation Of Inhaled Nitrobenzene In CD Rats
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1 Jul 2016 In a study conducted similarly to OECD TG 403, male Crl:CD rats (n=10/dose) dose inhalation toxicity study in male and female SD rats,
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A preliminary evaluation of toxicity should start when chemicals are synthesized in the laboratory stage of the development of an industrial process.
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5 Sep 1997 reproductive toxicity are identified as members of the Retention of inhaled benzene by rats and mice after 6 hours (Sabourin et.
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WILDLIFE TOXICITY ASSESSMENT FOR 1,3-DINITROBENZENE toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. Fund. Appl. Toxicol.
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by CH NO An inhalation LC value of 556 ppm was calculated for Crl:CD rats exposed for 4 hours. developmental/reproductive toxicity of nitrobenzene to humans.
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after having evaluated the data on genetic effects of nitrobenzene in and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. Fundam.
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by S Bakand 2006 Cited by 3 DEVELOPMENT OF IN VITRO METHODS FOR. TOXICITY ASSESSMENT OF WORKPLACE. AIR CONTAMINANTS. Shahnaz Bakand. A thesis submitted for the degree of.
1 NITROBENZENE ICSC: 0065 Date of Peer Review: April
Development, US Environmental Protection Agency, Washington, DC, USA rats), but inhaled nitrobenzene was toxic and carcinogenic in both species and both
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by FJ Murray 2012 fetal tissue for a follow-on developmental toxicity study to characterize Of the 50 sperm/plug positive CD (Sprague Dawley) female rats,
25 male CD rats/group were given 1-chloro-2-nitrobenzene in the diet for 18 week inhalation study which also evaluated the reproductive organs and can
James Bus, Ph.D., DABT, Fellow ATS - Exponent
Inhalation Pharmacokinetics, RfP Review Consultant, 1982 reproductive toxicity study in Crl:CD(SD) rats with 2,4-dichlorophenoxyacetic acid.
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The preferred test species for evaluation of acute toxicity by the oral and inhalation routes is the rat, while the rat or rabbit are preferred for
The acute inhalative toxicity is moderate: LC50 (rat) ca. week inhalation study which also evaluated the reproductive organs and can therefore be taken
1-Chloro-2-nitrobenzene CAS: 88-73-3 - OECD Existing
by OHPV Chemicals was applied: NOAEL developmental toxicity is 100 mg/kg bw/day, 25 male CD rats/group were given 1-chloro-2-nitrobenzene in the diet for
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5 Nov 2012 Reproductive and. Developmentale. 0/13 (8 at highest dose), Sprague-Dawley. CD rat, gavage,. GDs 8−16, offspring observed through.
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29 Sep 2006 Summit Toxicology (PBPK Modeling and Risk Assessment) male CD-1 mice were exposed to 100 and 400ppm toluene by inhalation,.
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Given the limited data available about inhalation exposure from the primary sources, it is NOAEL for reproductive toxicity in rats was 179 mg/kg/d.
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by CA Act evaluate the relationship between human cancer and exposure spe- Inhalation exposure of rats to nitrobenzene did not cause sis-.2 pages
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by AET Levels Cited by 1 3.7 Reprotoxicity/Developmental effects and fertility Bruckner and Peterson (1981) evaluated the degree of narcosis in rats exposed to high
Developmental Toxicity Evaluation of Inhaled Nitrobenzene in
by RW TYL 1987 Cited by 18 KJMMERLE, G. (1987). Fundam. Appl. Toxicol. 8, 482-492. Pregnant CD (Sprague-Dawley) rats were exposed to nitrobenzene vapor (CAS Registry No.
Nitrobenzene - Wiley Online Library
Inhaled by rats or mice, nitrobenzene can induce tumours in the lungs, liver, Development toxicity evaluation of inhaled nitrobenzene in CD rats.
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13 Jul 2012 Inhalation Toxicity (2009). No. 106, Guidance Document for Histologic Evaluation of. Endocrine and Reproductive Test in Rodents (2009). No.
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by SW Australia 2012 Cited by 1 4.2.2 Acute inhalation toxicity and pulmonary effects reported in mice/rats subsided following exposure and there were no functional impairments.
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- Developmental toxicity evaluation of inhaled nitrobenzene in CD rats. Fundamental and Applied Toxicology. 1987, 8 : 482-492. 34 Dodd DE et al. -
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nitrobenzene. CAS No. 88-73-3 In male rats, the dermal LD50 is 655 mg/kg body weight and in fe- males it is in the The inhalation toxicity of o-chloronitrobenzene was de- termined at an reproductive toxicity study in mice treated with oral doses of up to 160 mg Groups of 10 male Cr1:CD rats (8 weeks old, weighing
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A computational toxicology assessment should be performed using Quantitative 10), 1-chloro-4-nitrobenzene did not induce tumors in male CD-1 rats.
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bioaccumulation potential or inherent toxicity to aquatic organisms. Although an Benzene, 1-methyl-2-nitro; 2-Methyl-1-nitrobenzene; 2-.
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cation of the urine and zinc reduction of the nitro group of nitrobenzene. (1987) Developmental toxicity evaluation of inhaled nitrobenzene in CD rats.28 pages
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by KI McMartin Cited by 136 nitrobenzene inhalation. Fiind Appl Toxicol. 1987;8:493-505. 509. Tyl RW et al. Developmental toxicity evaluation of inhaled nitrobenzene in. CD rats.
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2 Dec 1997 The MCRA Working Group's activities involve developing toxicity risk assessment values for materials and chemicals of mutual concern to DOD,
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Health effects in humans following inhalation exposure to nitrobenzene have been Necrosis in male Sprague-Dawley (CD) rats exposed to nitrobenzene at.121 pages
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by K Brigden Cited by 11 The reproductive toxicity of 3,4-DCA was confirmed in a study on the inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats.
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by World Health Organization 2009 Cited by 3 The potential carcinogenicity of inhaled nitrobenzene was evaluated following a 2- year exposure period in B6C3F1 mice, Fischer 344 rats and Sprague-Dawley (CD).
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24 Jul 2001 005589 CIIT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY-DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS. CD RATS AND B6C3F1.
Toxicological Review of Nitrobenzene - Integrated Risk
Summary of effects observed in developmental inhalation studies with nitrobenzene Neoplasms in F344 and CD rats and B6C3F1 mice exposed to nitrobenzene.250 pages
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3 Feb 2012 22.214.171.124 Conclusions on Reproductive Toxicity of selected neoplastic lesions in F-344 and Sprague-Dawley CD rats following nitrobenzene.
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A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals. Inhalation Carcinogenicity of Dichloromethane in Rats.
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4 Oct 2014 Summary of studies reporting toxicity of nitrobenzene to female F344 rats and male CD rats were exposed to nitrobenzene at 0, 1, 5 or.
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by JL Mauderly 1997 Cited by 85 usefulness of the rat for evaluation of lung cancer hazards from inhaled at The Sixth International Meeting on the Toxicology of Natural and Man-.
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Summary of Information Critical to Assessment of Toxic the four-hour inhalation exposure of rats to aniline is 552 ppm (2100 mg/m3) (Back et al.,.
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an acute oral toxicity study involving rats, the median lethal dose was not reproductive performance using six groups of 30 female Sprague-Dawley CD
Reproduction and Fertility Evaluations in CD Rats - CiteSeerX
by DE DODD 1987 Cited by 24 FUNDAMENTAL AND APPLIED TOXICOLOGY 8, 4 9 3 - 5 0 5 (1987). Reproduction and Fertility Evaluations in CD. Rats following Nitrobenzene Inhalation12.
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31 Jan 1996 groups of pregnant Crl:CD rats were exposed to 32, 100, or 282 ppm dimethylacetamide by inhalation for 6 hr/day from Days 6 through 15 of
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19 Aug 2015 Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. Fundam Appl Toxicol 22:328-340. CIIT. (1993).13 pages
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B6C3F1 mice, and male Sprague-Dawley (CD) rats. Exposure to nitrobenzene was 6 hours/day, Developmental Toxicity Evaluation of Inhaled. Nitrobenzene in
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by DV Belsito REPRODUCTIVE AND DEVELOPMENTAL TOXICITY. In a teratogenicity study, mated female Crl:CD(SD)BR rats received 6-hydroxyindole by gavage on days 6-.