Transplantation Of Fetal Tissues
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Fetal Tissues Tested for Microbial Sterility by Culture- and
strongly reducing the risk of sepsis after transplantation of fetal tissues. MATERIALS AND METHODS Fetal Tissue Samples Human fetal samples were collected after elective termination of pregnancy. Each woman donating fetal material gave informed consent and signed an appropri-ate form. The research and clinical practice at our cen-
Mice Engrafted with Human Fetal Thymic Tissue and
(2 Gy) whole body irradiation before introduction of human tissues, unless noted otherwise. Human fetal thymus and autologous liver tissues of 14 to 20 weeks of gestational age were obtained from cadaverous sources and processed and stored in X-vivo 15 serum-free culture medium (Lonza Biosciences, Allendale, New Jersey).
Kidney Tissue Reconstruction by Fetal Kidney Cell
the potential of fetal kidney cells to reconstitute kidney tissues. The grafts retrieved from omentum contained cystic fluids with concentrated solutes. However, trans-planted early fetal kidney cells had also differentiated into nonrenal tissues such as bone and cartilage. In addition, transplantation of fetal kidney cells from a later gestation
History of Fetal Tissue Research and Transplants
8 Reviewed in: Fine A, Transplantation of fetal cells and tissue: an overview, Can Med Assoc J 151, 1261, 1994 9 Folkerth RD, Durso R, Survival and proliferation of nonneural tissues, with obstruction of cerebral ventricles, in a parkinsonian patient treated with fetal allografts, Neurology 46, 1219, 1996
Implantation of the clinical-grade human neural stem cell line,
intracerebral transplantation using human fetal striatal tissues have demonstrated limited benefits and survival.2 A sustainable source of ethically approved, safe, and potent stem cells is one of the most important requirements for the devel-opment of an effective cell therapy, and this holds for HD as well.
on human reproductive tissue donation for research
Parkinson s disease that involved transplantation of fetal cells and tissue into the brains of persons living with this condition; the use of these tissues for transplantation and not merely as a substrate for experimentation in the laboratory clashed with the political environment, precipitating the moratorium. 29
Organ Transplantation: An Overview from History to Challenges
There are six ways that are useful in transplantation of organ/ tissue. 1. Autograft 2. Allograft 3. Isograft 4. Xenograft 5. Domino transplant 6. Transplantation is Obese People Autograft Type of transplantation in which transplantation occurs within same subject. It occurs only in those tissues that have the
Transplantation of embryonic stem cellsat the turn of the
TRANSPLANTATION OF FETAL STEM CELLS AT THE TURN OF THE FIRST AND THE SECOND WAVE OF DEVELOPMENT A.V.Karpenko Coordinating Center for Transplantation of Organs, Tissues and Cells of Ministry of Health, Kiev, Ukraine, In the history of medicine, the world has not witnessed a more significant and global
Fetal Tissue Research: State Regulation of the Donation of
sue research for over fifty years.4 Fetal tissue research shows great potential for advancement in the treatment and cure of vari-ous diseases and in the area of tissue transplantation.5 However, much controversy surrounds this research because scientists ob-tain the majority of fetal tissue used in such research from elective
Fetal Tissue Transplantation: An Ethical Analysis
fetal tissue transplantation research until an NIH appointed advisory committee could answer ten questions posed by him. The committee answered the questions and in December, 1988 a majority of its members approved the use of fetal tissue from induced aborted fetuses for human transplantation purposes.6 Dr. Louis
Transplantation of tissue: overview
tissues.2 Histocompatibility antigens are expressed at lower levels in some fetal tissues than in corresponding transplantation of fetal thymus tissue.4'42 This has now
Engraftment Potential of Adipose Tissue-Derived Human
model . We highlighted the safety of ﬂ-MSCs for fetal transplantation in the pregnant rabbit model, the efﬁciency, and persistence of ﬂ-MSC engraftment and transgene ex-pression in fetal organs, and the absence of immune reactions against both allogeneic ﬂ-MSCs and transgenic EGFP after fetal transplantation.
Human immune system development and survival of non-obese
Tissue transplantation Human fetal thymus and fetal liver (gestational age between 16 and 20 weeks) specimens were provided by Advanced Bioscience Resources (Alameda, CA, USA) or StemExpress (Placerville, CA, USA). Upon receipt, tissues were washed with RPMI supplemented with penicillin G (100 U/ml), streptomycin (100 mg/ml), fungizone (0 25
Fetal Tissue Research: Legal Regulation Of Human Fetal Tissue
fetal tissue transplantation issue. II. BACKGROUND Although fetal tissue transplantation is still highly experimental, recent medical studies involving tissue from aborted fetuses suggest that it may be an effective therapy for diseases in which degenerative processes or traumatic
Plasma DNA tissue mapping by genome-wide methylation
marrow (18) and solid organ transplantation (e.g., liver trans-plantation) (13, 19) has provided a glimpse of the contribution by these various organs into the circulating DNA pool. On the other hand, different DNA methylation signatures can be found in different tissues (20, 21) and even between different cell types within a particular tissue
Intracerebral transplantation: basic and clinical
The neural tissues used for grafting typically are obtained from embryonic donors, as cells isolated from the adult brain do not survive well through the grafting procedures. The necessity for using fetal tissues for transplantation raises several interesting issues relating to neural development: 1)
Tissue culture before transplantation of frozen-thawed human
indicated that follicle cells were in a proliferative state after culture and transplantation. Conclusion(s): The viability and development of human fetal follicles may be improved by pretransplant tissue culture. The optimal culture duration before transplantation of fetal ovarian tissue is 6 days. (Fertil Steril 2010;93:913 9.
Fetal Tissue Transplantation: Can It Be Morally Insulated
fetal tissue transplantation can be adequately assessed. The ethics of fetal tissue transplantation was recently debated by the National Institutes of Health (NIH) Human Fetal Tissue Transplantation Research Panel. The panel was established in 1988 after the Assistant Secretary for Health issued a moratorium on
Legitimization of Fetal Tissue Transplantation Research under
search with fetal tissues to develop therapy (e.g., the development of the polio and rubella vaccines) and as transplantation research that uses fetal tissue as therapy. It is this latter use of fetal tissues for research purposes that is the focus of this paper. Although willing to sanction consensual-by-proxy, therapeutic in-
TRANSPLANTATION OF FETAL TISSUE - IRB
IGS: Transplantation of Fetal Tissue Version F2512 Page 1 of 2 TRANSPLANTATION OF FETAL TISSUE Definition. For the purposes of this law, the term human fetal tissue means tissue or cells obtained from a dead human embryo or fetus after a spontaneous or induced abortion, or after a stillbirth.
PAPER Unilateral transplantation of human primary fetal
Neural transplantation is effective in animal models of HD and offers a potential strategy for brain repair in patients. The authors report a safety study of unilateral transplantation of human fetal striatal tissue into the striatum of four patients with HD. Subjects and methods: Stereotaxic placements of cell suspensions of human fetal ganglionic
White Paper on The Pricing of Fetal Tissue new
acceptance of directed fetal tissue donations.4 The Committee prohibition on the sale of fetal tissue is described as making the transfer of fetal tissue parallel with donation of other organs under the Organ Procurement and Transplantation Act.5 But the Committee Report adds, Indeed the Committee has dealt with fetal tissue more
Neural stem cell-based treatment for neurodegenerative diseases
Since the late 1980s, transplantation of human fetal ventral mesencephalic tissues into the striatum of PD patients has been used as a successful therapy for patients with advanced disease.25 28 However, this fetal tissue trans-plantation has serious problems associated with ethical and religious questions and logistics of acquiring fetal
COMMENTARY Fetal Pancreas as a Source for Islet
An additional challenge associated with fetal organ transplantation is the relatively prolonged latency period between transplantation and commencement of functional activity of the graft. Presumably, this reﬂects the time re-quired for differentiation and growth of the grafted tissue after implantation (5). Another obstacle to achieve suc-
Treatment of gingival defects with gingival mesenchymal stem
and after transplantation can differentiate into desired tissues to repair defects. An important issue is to separ-ate high-quality seed cells from available sources for tis-sue regeneration. Fetal stem cells can be isolated from fetal tissue and, being more primitive than adult stem cells, can maintain self-renewal and differentiation potential.
Transplantation of Fetal Stem Cells: a New Horizon for
on the characteristics of fetal stem cells as well as their extraction methods and the opportunity they provide for treatment of different degenerative diseases. Fetal tissues stem cells Fetal stem cells can be harvested from fetal blood and bone marrow tissues as well as other fetal or-gans such as the liver and kidney. Fetal stem cells
DOI: 10.3727/096368916X692735 CT-1632 Provisionally Accepted
CT-1632 Cell Transplantation early e-pub; provisional acceptance 07/27/2016 ABSTRACT Cell preparations to be used in clinical practice must be free of infectious agents. Safety concerns are especially elevated upon the use of human fetal tissues which are otherwise highly advantageous in cell therapy.
Fetal Tissue for Experimentation and Transplantation
The use of fetal tissue for experimentation and transplantation introduces the opportunity for the gross abuse of human life, such as conception and abortion for the sole purpose of obtaining fetal tissue. Also, the use of fetal tissue from elective abortions could be interpreted as further justification for abortion.
Fetal stem cell transplantation: Past, present, and future
Since 1928, human fetal tissues and stem cells have been used worldwide to treat various conditions. Al-though the transplantation of the fetal midbrain sub-stantia nigra and dopaminergic neurons in patients suffering from Parkinson s disease is particularly note-worthy, the history of other types of grafts, such as
Intestinal stem cell transplantation
studies showed that rat fetal endoderm cells were able to develop intestinal mucosa that contained differentiated cells when xenografted under the skin of nude mice [21, 22]. In these experiments, the graft tissues were ana-lyzed by 4 weeks post-transplantation at the latest, which seemed insufﬁcient to demonstrate long-term self-renewal
Engrafting fetal liver cells into multiple tissues of healthy
grafted into multiple tissues of healthy animals indicates that they can be used to replace the natural loss of cells in adult organisms. Key words: Fetal cells, Transplantation, Engraftment, Immune suppression INTRODUCTION The regeneration and replacement of damaged tissues is a major guest of current
Human Fetal Tissue: A Critical Resource for Biomedical Research
Fetal tissue is an essential gold-standard resource that enables laboratory-based research into how human tissues and organs develop. With the consent of donors, this unique and valuable tissue can be used for
Politics and Privacy: Refining the Ethical and Legal Issues
afforded fetal tissue transplantation will be influenced by the abortion debate. However, when the extent and dimensions of that synergy are analyzed, it is difficult not to conclude that we are faced with a pur-poseful confusion of the issues destined to pre-empt any meaningful dis-cussion of fetal tissue transplantation.
Multi-lineage Lung Regeneration by Stem Cell Transplantation
poietic stem cells (HSCs) in E16 fetal and in the adult lung and investigated the feasibility of attaining immune tolerance for lung progenitor engraftment in the presence or absence of addi-tional infusion of BM-derived HSC. On the basis of this analysis, we conclude that although fetal lung cell transplantation could
Human organ and tissue transplantation
cells, tissues and organs as such in order to facilitate national and international traceability of materials of human origin for transplantation; 3. REQUESTS the Director-General: (1) to disseminate the updated Guiding Principles on Human Cell, Tissue and Organ Transplantation as widely as possible to all interested parties;
Journal of Molecular and Genetic Medicine This These
Advantages of Fetal Tissue Transplantation The fetus including the fetal tissues is rich in stem cells, progenitor or fetal cells. They express low mRNA transcripts of HLA-G and the mesenchymal stem cell content of the fetus can have an anti-inflammatory effect as observed under in vitro conditions [16,17].
Transplantation of Fetal Kidney Tissue Reduces Cerebral
fetal, but not adult, kidney cortex, the possibility that transplan tation of fetal kidney tissue could serve as a cellular reservoir for such molecules and protect against ischemic injury in ce rebral cortex was examined. Fetal kidneys obtained from rat embryos at gestational day 16, and adult kidney cortex, were
Replacing what s lost: a new era of stem cell therapy for
SEURO consortium revisited fetal ventral midbrain grafts for PD treatment in a multi-center trial (NCT01898390) . Results of these early fetal cell transplantation studies tended to be highly variable be-cause of the lack of standardization in fetal material to be transplanted. However, key conclusions could be drawn from these studies.
Fetal Tissue Research and Abortion: Do They Have a Future
claiming that the use of fetal tissues for transplantation is morally wrong. The thought of injecting electively aborted fetuses into the brain of another human being is troublesome to them. Societal at-titudes towards abortion seem to determine societal attitudes to-wards fetal tissue research. This Comment will examine fetal tissue
Autologous Transplantation of Amniotic Fluid-Derived
Cell Transplantation, Vol. 20, pp. 1015 1031, 2011 and their ability to differentiate into various lineages pling of maternal and fetal tissues that were fixed in 4% such as myogenic