Mutant P53 And Aberrant Cytosine Methylation Cooperate To Silence Gene Expression

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Epigenetic Dysregulation in Thyroid Neoplasia

Epigenetic gene regulation Epigenetic modiļ¬cation is responsible for regulation of gene expression by mammalian cells without involving changes in the underlying genomic DNA sequence (Fig. 1). The mechanisms include methylation of cytosine * Corresponding author. Ontario Cancer Institute, 610 University Avenue #8-327, Toronto, ON, M5P 2S3